13

Zelavespib

13 Publications Verification

Cat. No.: HY-11038

CAS No.: 873436-91-0

Purity: 99.93%

Synonyms: PU-H71

Target:

HSP

Research Areas:

Cancer

Zelavespib (PU-H71) is a potent Hsp90 inhibitor, with an IC₅₀ of 51 nM in MDA-MB-468 cells.

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13

Zelavespib hydrochloride

13 Publications Verification

Cat. No.: HY-11038B

CAS No.: 2095432-24-7

Purity: 98.89%

Synonyms: PU-H71 hydrochloride

Target:

HSP

Research Areas:

Cancer

Zelavespib (PU-H71) hydrochloride is a potent Hsp90 inhibitor, with an IC₅₀ of 51 nM in MDA-MB-468 cells.

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13

Zelavespib formic

13 Publications Verification

Cat. No.: HY-11038D

Purity: 97.39%

Synonyms: PU-H71 formic

Target:

HSP

Research Areas:

Cancer

Zelavespib formic (PU-H71 formic) is a potent Hsp90 inhibitor with an IC₅₀ value of 51 nM for Hsp90 in MDA-MB-468 cells .

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1

MMAF-OMe

1 Cited Publications

Cat. No.: HY-79256

CAS No.: 863971-12-4

Synonyms: Monomethyl auristatin F methyl ester

Target:

ADC Payloads

Research Areas:

Cancer

MMAF-Ome, an antitubulin agent, is also an ADC cytotoxin. MMAF-Ome inhibits several tumor cell lines with IC₅₀s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4 ^-) cell lines, respectively.

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1

SI-2

1 Cited Publications

Cat. No.: HY-101447

CAS No.: 223788-33-8

Synonyms: EPH 116

Target:

Src Apoptosis

Research Areas:

Cancer

SI-2 (EPH 116) is an inhibitor for steroid receptor coactivator-3 (SRC-3), which reduces the transcriptional activity and protein concentration of SRC-3 in cells, exhibits cytotoxicity in cancer cell, inhibits migration of MDA-MB-468, induces apoptosis of MDA-MB-468. SI-2 inhibits the tumor growth in mouse models, without significant toxicity for heart and other major organs (20 mg/kg) .

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C188

Cat. No.: HY-112338

CAS No.: 823828-18-8

Purity: 98.29%

Synonyms: CPD188

Target:

STAT Apoptosis

Research Areas:

Cancer

C188 (CPD188) is a STAT3 inhibitor with anticancer effects. C188 inhibits STAT3 SH2/pY-peptide binding (IC₅₀ of 20 µM against pY-peptide binding) and IL-6-mediated STAT3 phosphorylation. C188 is selective for STAT3 over STAT1. C188 inhibits nuclear-to-cytoplasmic translocation of Stat3. C188 shows highly active induces apoptosis in breast cancer cell lines with constitutive Stat3 activation (EC₅₀s of 0.73 µM, 3.96 µM, and 7.01 µM in MDA-MB-468, MDA-MB-231, and MDA-MB-435 cultures, respectively) .

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PHGDH-IN-5

Cat. No.: HY-161456

CAS No.: 17402-86-7

Target:

Phosphoglycerate Dehydrogenase (PHGDH)

Research Areas:

Cancer

PHGDH-IN-5 (Compound B12) is a covalen inhibitor of PHGDH with an IC₅₀ value of 0.29 μM. PHGDH-IN-5 can inhibit cell proliferation in cancer cell lines overexpressing PHGDH. PHGDH-IN-5 can reduce the production of serine derived from glucose in MDA-MB-468 cells .

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