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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
50 Results for "
MEP
" in MedChemExpress (MCE) Product Catalog:
Products (50)
50 Results for "MEP" in MCE Product Catalog:
7
7 Cited Publications
Target:
Research Areas:
LLY-283, a chemical probe, is a potent, selective and oral protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 22 nM and a Kd of 6 nM for PRMT5:MEP50 complex, and shows antitumor activity .
1
1 Cited Publications
Cat. No.: HY-P77083
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MEP1A; MEPrin A, Alpha (PABA Peptide Hydrolase); MEPrin A Subunit Alpha; PPH Alpha; PABA Peptide Hydrolase; BA268F1.1 (MEPrin A Alpha (PABA Peptide Hydrolase)); Endopeptidase-2; Metalloendopeptidase; PPHA; MEPrin A Subunit; N-Benzoyl-L-Tyrosyl-P-Amino-Ben
Species:
Human
Source:
HEK293
Cat. No.: HY-173561
CAS No.: 3109377-60-5
Target:
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MS115 is a selective PRMT5/MEP50 PROTAC degrader, with DC50 values of 17.4 nM and 11.3 nM for PRMT5 and MEP50, respectively. MS115 promotes PRMT5/MEP50 ubiquitination and degradation. MS115 shows anticancer activity against breast cancer .
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PRMT5:MEP50 PPI is a novel PRMT5:MEP50 protein-protein interaction (PRMT5:MEP50 PPI) inhibitor, shows anti-tumor activity and anti-proliferative activity of lung and prostate cancer cells .
Cat. No.: HY-126256A
Purity: 99.50%
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Research Areas:
PRMT5 IN-1 hydrochloride (compound 9), a hemiaminal, is a potent, selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 11 nM for PRMT5/MEP50. PRMT5 IN-1 hydrochloride can be converted to aldehydes and react with C449 to form covalent adducts under physiological conditions .
Cat. No.: HY-126256
CAS No.: 2366149-83-7
Target:
Research Areas:
PRMT5 IN-1, a hemiaminal, is a potent, selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 11 nM for PRMT5/MEP50. PRMT5 IN-1 can be converted to aldehydes and react with C449 to form covalent adducts under physiological conditions .
Cat. No.: HY-178028
CAS No.: 3113303-04-8
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PRMT5-IN-53 is a gut-restricted and orally active PRMT5 inhibitor with pIC50s of ≥ 9.7 against hPRMT5 and mPRMT5. PRMT5-IN-53 binds to the PRMT5:MEP50 complex with a KD of 11.3 pM. PRMT5-IN-53 effectively inhibits PRMT5 locally in the intestines of mice, significantly reducing the number and area of polyps, while avoiding systemic hematological toxicity (such as anemia, neutropenia). PRMT5-IN-53 can be used for the study of colorectal cancer especially for familial adenomatous polyposis (FAP) .
Cat. No.: HY-172082
CAS No.: 2749985-70-2
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MEP-FUBICA is structurally categorized as a synthetic cannabinoid.
Cat. No.: HY-RS08336
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Research Areas:
MEP1A Human Pre-designed siRNA Set A contains three designed siRNAs for MEP1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS26955
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Mep1a Rat Pre-designed siRNA Set A contains three designed siRNAs for Mep1a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-139823
CAS No.: 2567564-23-0
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PRMT5-IN-10 has promising structure-dependent inhibition of the protein methyltransferase PRMT5:MEP50 complex.
Cat. No.: HY-139823A
CAS No.: 2567564-33-2
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PRMT5-IN-11 is a promising structure-dependent inhibition of the protein methyltransferase PRMT5:MEP50 complex in the (sub)micromolar range.
Cat. No.: HY-RS18386
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Research Areas:
Ephb6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ephb6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS03340
Research Areas:
CTSL Human Pre-designed siRNA Set A contains three designed siRNAs for CTSL gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS09345
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NLN Human Pre-designed siRNA Set A contains three designed siRNAs for NLN gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS03341
Research Areas:
Ctsl Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ctsl gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-N9923
CAS No.: 206440-72-4
Target:
Cat. No.: HY-158818
CAS No.: 2260608-07-7
DXR-IN-2 is a 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) inhibitor and an antimalarial agent (IC50: 0.1062 μM for Plasmodium falciparum DXR and 0.369 μM for Plasmodium falciparum). DXR-IN-2 inhibits Plasmodium falciparum growth by suppressing the methyl erythritol phosphate (MEP) pathway via DXR .
Cat. No.: HY-RS20446
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Research Areas:
Mep1a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mep1a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS08337
Target:
Research Areas:
MEP1B Human Pre-designed siRNA Set A contains three designed siRNAs for MEP1B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
