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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
MHC-mismatched
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "MHC-mismatched" in MCE Product Catalog:
Cat. No.: HY-129387
CAS No.: 2378640-25-4
Target:
Research Areas:
Perforin-IN-1 is a perforin inhibitor that blocks perforin-mediated lysis of target cells by cytotoxic lymphocytes. Perforin-IN-1 achieves perforin inhibition in a mouse bone marrow transplantation model, protecting MHC-mismatched allogeneic bone marrow stem cell grafts from NK cell-mediated rejection. Perforin-IN-1 can be used for research on graft rejection .
Cat. No.: HY-115464
CAS No.: 150661-91-9
Target:
Research Areas:
NC1153 is a Mannich base with the activity to block IL-2-induced JAK3 activation and its downstream substrate STAT5a/b. NC1153 effectively prolongs the survival of kidney transplants in MHC/non-MHC mismatched rats. NC1153 promotes long-term graft survival and includes multiple toxicity protection for recipients. NC1153 combined with cyclosporine A (CsA) can synergistically prolong graft survival without producing nephrotoxicity, myelotoxicity or lipotoxicity .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
