17 Results for "

MKK3

" in MedChemExpress (MCE) Product Catalog:
Products (17)

17 Results for "MKK3" in MCE Product Catalog:

14
Ro 31-8220 mesylate
Ro 31-8220 mesylate
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14 Publications Verification
Cat. No.: HY-13866
CAS No.: 138489-18-6
Purity:  99.57%
Synonyms: Ro 31-8220 methanesulfonate; Bisindolylmaleimide IX mesylate
Target:  

PKC JNK

Research Areas:  

Cardiovascular Disease Neurological Disease Cancer

Ro 31-8220 mesylate is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC50s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7. Ro 31-8220 mesylate can also inhibit the expression of MKP-1, induce the expression of c-Jun, and activate JNK, and these effects possess pharmacological properties independent of PKC [3] .
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4
Gossypetin
Gossypetin
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4 Cited Publications
Cat. No.: HY-119917
CAS No.: 489-35-0
Purity:  ≥99.0%
Category:  

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