13 Results for "

MKN 45

" in MedChemExpress (MCE) Product Catalog:
Products (13)

13 Results for "MKN 45" in MCE Product Catalog:

4
4-DAMP
4-DAMP
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4 Cited Publications
Cat. No.: HY-100958
CAS No.: 1952-15-4
Purity:  99.96%
Synonyms: 4-DAMP methiodide
Target:  

mAChR Apoptosis MMP EGFR Interleukin Related

Research Areas:  

Inflammation/Immunology Cancer

4-DAMP (4-DAMP methiodide) is a potent and selective antagonist of M3 receptors and also has a high affinity for the closely-related M5 receptors. 4-DAMP combined with 5-Fluorouracil (5-Fu) (HY-90006) could significantly reduce the cell viability and enhance apoptosis in MKN45 and BGC823 gastric cancer cells. 4-DAMP inhibits lipopolysaccharide (LPS)- and tobacco-induced pulmonary inflammation and reduces mucin 5AC (MUC5AC), oligomeric mucus/gel-forming secretion .
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PRO-6E
PRO-6E
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Cat. No.: HY-160506
CAS No.: 2353493-69-1
Target:  

PROTACs c-Met/HGFR Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

PRO-6E is an oral active PROTAC based on Cereblon ligand, and induces the degradation of MET with maximum degradation of 81.9% at 1 μM in MKN-45 cells. PRO-6E inhibits tumor growth in vivo and in vitro. PRO-6E induces cell apoptosis and induces cell arrest .
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Thujopsene
Thujopsene
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Cat. No.: HY-W587878
CAS No.: 470-40-6
Target:  

Cytochrome P450 Pyruvate Kinase Fungal Apoptosis Insecticide

Research Areas:  

Infection Cancer

Thujopsene is the inhibitor for cytochrome P450, that inhibits CYP2B6, CYP3A4, CYP2C19, CYP2C8, CYP2C9 with IC50s of 1.3, 12.6, 13.6, 29.8, and 44.9 μM, respectively. Thujopsene binds to PKM2, inhibits the metabolism pathway of cancer cell, induces apoptosis in MKN45, thereby exhibiting antitumor efficacy. Thujopsene exhibits anti-termite and antifungal activities through autoxidation .
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CDK9/EZH2-IN-1
CDK9/EZH2-IN-1
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Cat. No.: HY-176165
CAS No.: 3081246-18-3
Target:  

CDK Histone Methyltransferase

Research Areas:  

Cancer

CDK9/EZH2-IN-1 (Compound D16) is a CDK9/EZH2 dual-target inhibitor (IC50: 83.9/108.6 nM). CDK9/EZH2-IN-1 induces apoptosis and DNA double-strand breaks (DSBs). CDK9/EZH2-IN-1 inhibits the proliferation activity of MKN45, MDA-MB-453 and SW620 cancer cells (IC50 values are 136.3, 171.3 and 315.7 nM, respectively) .
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MET/PDGFRA-IN-2
MET/PDGFRA-IN-2
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Cat. No.: HY-149511
CAS No.: 3125694-57-4
Target:  

c-Met/HGFR Apoptosis PDGFR

Research Areas:  

Cancer

MET/PDGFRA-IN-2 (compound 8h) is a MET and PDGFRA protein inhibitor. MET/PDGFRA-IN-2 induces cell apoptosis. MET/PDGFRA-IN-2 inhibits proliferation of MET-positive cells (IC50s: 9.7, 6.1, 12.0, 11.5, 8.6, 34.4 μM for AsPc-1, EBC-1, MKN-45, Mia-Paca-2, HT-29, K562 cells respectively) .
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MET/PDGFRA-IN-1
MET/PDGFRA-IN-1
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Cat. No.: HY-149510
CAS No.: 3125694-48-3
Target:  

c-Met/HGFR Apoptosis PDGFR

Research Areas:  

Cancer

MET/PDGFRA-IN-1 (compound 8c) is a MET and PDGFRA protein inhibitor (IC50: 36 μM for MET). MET/PDGFRA-IN-1 inhibits MET phosphorylation and induces cell apoptosis. MET/PDGFRA-IN-1 inhibits proliferation of MET-positive cells (IC50s: 15.3, 19.0, 22.0, 25.6, 21.0, 31.5 μM for AsPc-1, EBC-1, MKN-45, Mia-Paca-2, HT-29, K562 cells respectively) .
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Lobetyol
Lobetyol
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Cat. No.: HY-117652
CAS No.: 136171-87-4
Category:  

Campanulaceae Extract Natural Products Plants 500 - Internal Server Error | MedChemExpress

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