Purity: 99.64%

Target:

Research Areas:

MMP2-IN-3 (compound 2) is a potent MMP-2 (matrix metalloproteinases) inhibitor, with an IC₅₀ of 31 μM. MMP2-IN-3 also shows inhibitory activity against MMP-9 and MMP-8, with IC₅₀ values of 26.6, and 32 μM, respectively .

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4

Prinomastat

4 Cited Publications

Cat. No.: HY-12170

CAS No.: 192329-42-3

Purity: 99.27%

Synonyms: AG3340; KB-R9896

Target:

MMP Apoptosis

Research Areas:

Cancer

Prinomastat (AG3340) is a broad spectrum, potent, orally active metalloproteinase (MMP) inhibitor with IC₅₀s of 79, 6.3 and 5.0 nM for MMP-1, MMP-3 and MMP-9, respectively. Prinomastat inhibits MMP-2, MMP-3, MMP-13 and MMP-9 with K_is of 0.05 nM, 0.3 nM, 0.03 nM and 0.26 nM, respectively. Prinomastat crosses blood-brain barrier. Antitumor avtivity .

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4

Prinomastat hydrochloride

4 Cited Publications

Cat. No.: HY-12170A

CAS No.: 1435779-45-5

Purity: 98.18%

Synonyms: AG3340 hydrochloride; KB-R9896 hydrochloride

Target:

MMP Apoptosis

Research Areas:

Cancer

Prinomastat hydrochloride (AG3340 hydrochloride) is a broad spectrum, potent, orally active metalloproteinase (MMP) inhibitor with IC₅₀s of 79, 6.3 and 5.0 nM for MMP-1, MMP-3 and MMP-9, respectively. Prinomastat hydrochloride inhibits MMP-2, MMP-3, MMP-13 and MMP-9 with K_is of 0.05 nM, 0.3 nM, 0.03 nM and 0.26 nM, respectively. Prinomastat hydrochloride can cross blood-brain barrier. Antitumor avtivity .

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2

XL-784

2 Cited Publications

Cat. No.: HY-19485

CAS No.: 1224964-36-6

Target:

MMP

Research Areas:

Cardiovascular Disease

XL-784 is a selective matrix metalloproteinases (MMP) inhibitor, with IC₅₀s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, MMP-13, respectively.

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1

PD-166793

1 Cited Publications

Cat. No.: HY-107428

CAS No.: 199850-67-4

Purity: 99.21%

Target:

MMP

Research Areas:

Cardiovascular Disease

PD-166793 is a potent, selective, orally active and wide-broad spectrum inhibitor of MMP, exhibiting nanomolar potency against MMP-2, MMP-3 and MMP-13 (IC₅₀=4, 7, and 8 nM, respectively) and micromolar potency vs MMP-1, -7 and -9 (IC₅₀=6.0, 7.2, and 7.9 μM, respectively). PD-166793 can attenuate left ventricular remodeling and dysfunction in a rat model of progressive heart failure .

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Tanomastat

Cat. No.: HY-12168

CAS No.: 179545-77-8

Purity: 99.7%

Synonyms: BAY 12-9566

Target:

MMP

Research Areas:

Cancer

Tanomastat (BAY 12-9566) is an orally bioavailable, non-peptidic biphenyl matrix metalloproteinases (MMPs) inhibitor with a Zn-binding carboxyl group. The K_i values are 11, 143, 301, and 1470 nM for MMP-2, MMP-3, MMP-9, MMP-13 respectively. Tanomastat shows anti-invasive and antimetastatic activity in several experimental tumor models .

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Chemotactic Domain of Elastin

Cat. No.: HY-P4998

CAS No.: 92899-39-3

Target:

Biochemical Assay Reagents

Research Areas:

Cancer

Chemotactic Domain of Elastin is an elastin-derived chemotactic hexapeptide that interacts with Galectin-3, integrin αvβ3, and elastin-binding protein (EBP) and promotes cell chemotaxis and migration. Chemotactic Domain of Elastin promotes melanoma cell migration by regulating invasion-related molecules such as CXCR-4/CXCL-12, MMP-2/MMP-3, cell adhesion molecules, and VEGF-C. Chemotactic Domain of Elastin is used for research on elastin-derived peptide signaling and tumor cell migration and invasion .

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XL-784 free base

Cat. No.: HY-112160

CAS No.: 1356992-21-6

Target:

MMP

Research Areas:

Cardiovascular Disease

XL-784 free base is a selective matrix metalloproteinases (MMP) inhibitor, with IC₅₀s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1, MMP-2, MMP-3, MMP-8, MMP-9 and MMP-13, respectively .

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