4

Dienogest

4 Cited Publications

Cat. No.: HY-B0084

CAS No.: 65928-58-7

Synonyms: STS 557

Target:

Progesterone Receptor

Research Areas:

Endocrinology

Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE₂ synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia .

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2

CAY10526

2 Cited Publications

Cat. No.: HY-118119

CAS No.: 938069-71-7

Purity: 99.12%

Target:

PGE synthase YB-1 Apoptosis JAK STAT TGF-β Receptor TGF-beta/Smad PI3K Akt

Research Areas:

Cancer

CAY10526 is an inhibitor of Y-box binding protein 1 (YB-1) and microsomal prostaglandin E2 synthase 1 (mPGES1). CAY10526 inhibits the production of PGE₂ by suppressing YB-1 and mPGES1. CAY10526 induces cell apoptosis (apoptosis) and inhibits the JAK/STAT, TGF-β/Smad3 and PI3K/AKT signaling pathways. CAY10526 can be used in research related to melanoma, prostate cancer, esophageal adenocarcinoma, T-cell lymphoma, etc .

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1

Methoxyamine hydrochloride

1 Cited Publications

Cat. No.: HY-Y0958

CAS No.: 593-56-6

Synonyms: O-Methylhydroxylamine hydrochloride; TRC-102 hydrochloride

Target:

DNA/RNA Synthesis Apoptosis

Research Areas:

Cancer

Methoxyamine (O-Methylhydroxylamine) hydrochloride is an orally active and potent base excision repair (BER) inhibitor. Methoxyamine hydrochloride binds to 3’ hydroxyl groups that are left behind by 3-methylpurine-DNA glycosylase (MPG) following excision of the damaged base and thus inhibits BER activity. Methoxyamine hydrochloride binds directly to the apyrimidinic (AP) sites. Methoxyamine hydrochloride synergistically enhances the therapeutic efficacy of DNA-damaging agents .

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1

HPGDS inhibitor 1

1 Cited Publications

Cat. No.: HY-10439

CAS No.: 1033836-12-2

Purity: 99.42%

Target:

PGE synthase

Research Areas:

Inflammation/Immunology

HPGDS inhibitor 1 is a potent, selective and orally active Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC₅₀s of 0.6 nM and 32 nM in enzyme and cellular assays, respectively. HPGDS inhibitor 1 does not inhibit human L-PGDS, mPGES, COX-1, COX-2, or 5-LOX .

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1

MF63

1 Cited Publications

Cat. No.: HY-13283

CAS No.: 892549-43-8

Purity: 99.55%

Target:

PGE synthase

Research Areas:

Inflammation/Immunology

MF63 is a selective and orally active inhibitor of mPGES-1. MF63 reduces the accumulation of PGE₂, relieves pyresis, hyperalgesia, and inflammatory pain by inhibiting mPGES-1 .

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Vipoglanstat

Cat. No.: HY-147416

CAS No.: 1360622-01-0

Purity: 99.81%

Synonyms: BI 1029539; GS-248; OX-MPI

Target:

PGE synthase

Research Areas:

Infection Cancer

Vipoglanstat (BI 1029539), a carboxamide, is a potent and selective, non-peptide and orally active small molecular inhibitor of human prostaglandin E synthase 1 (mPGES-1). Vipoglanstat also has anti-inflammatory activity .

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MPG peptides, Pβ

Cat. No.: HY-P4076

CAS No.: 791642-10-9

Target:

HIV DNA Alkylator/Crosslinker

Research Areas:

Infection

MPG peptides, Pβ is an amphipathic cell-penetrating peptide. MPG peptides, Pβ consists of three components: the hydrophobic fusion sequence (GALFLGFLGAAGSTMGA) of HIV glycoprotein 41, a spacer domain (WSQP), and the nuclear localization signal (KKKRKV) of the large T antigen of Simian virus 40. MPG peptides, Pβ can form stable non-covalent complexes with nucleic acids (including DNA) through electrostatic interactions and improve their intracellular delivery. MPG peptides, Pβ can be used in studies of HIV-1-related immune responses .

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