Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
MPP8 chromodomain
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "MPP8 chromodomain" in MCE Product Catalog:
2
2 Cited Publications
Target:
Research Areas:
MS37452 is a potent inhibitor of CBX7 chromodomain binding to H3K27me3, with a Kd of 27.7 μM. MS37452 can derepress transcription of polycomb repressive complex target gene p16/CDKN2A by displacing CBX7 binding to the INK4A/ARF locus in prostate cancer cells .
1
1 Cited Publications
Cat. No.: HY-141716
Purity: 99.19%
Target:
Research Areas:
SW2_110A is a selective chromobox 8 chromodomain (CBX8 ChD) inhibitor with a Kd of 800 nM. SW2_110A shows minimal 5-fold selectivity for CBX8 ChD over all other CBX paralogs in vitro .
Target:
Research Areas:
CHD1Li 6.11 is a potent and orally active Chromodomain Helicase DNA Binding Protein 1 Like (CHD1L) (oncogenic gene) inhibitor (IC50 = 3.3 µM for cat-CHD1L recombinant protein). CHD1Li 6.11 can inhibit EMT, induce mesenchymal-epithelial transition (reverse EMT) and promote apoptosis in tumor organoid models. CHD1Li 6.11 can be used for the research of cancer, such as colorectal cancer .
Cat. No.: HY-147058
Purity: 99.77%
Target:
Research Areas:
SW2_152F is a potent, selective chromobox 2 chromodomain (CBX2 ChD) inhibitor with a Kd of 80 nM. SW2_152F displays 24-1000-fold selectivity for CBX2 ChD over other CBX paralogs in vitro . SW2_152F is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-126327A
Purity: ≥98.0%
Target:
Research Areas:
Cat. No.: HY-126327
CAS No.: 2920299-34-7
Target:
Research Areas:
Cat. No.: HY-183603
Target:
Research Areas:
FRC-222 is a CHD1 tandem chromodomain inhibitor with a Kd of 0.15 μM and an IC50 of 0.18 μM. FRC-222 binds to the H3K4me3 binding site of CHD1 tandem chromodomain via aromatic cage interactions and extended ligand contacts. FRC-222 can be used for the research of prostate cancer[1].
Cat. No.: HY-181089
CAS No.: 3124602-03-2
Target:
Research Areas:
CBX2-IN-1 is a CBX2 inhibitor with an IC50 of 9.6 μM. CBX2-IN-1 binds the CBX2 chromodomain’s H3K27me3 binding channel, blocks interaction between CBX2 and H3K27me3, and exhibits selective affinity toward CBX2, CBX4, CBX6, CBX7, and CBX8 over CBX1, CBX3, and CBX5. CBX2-IN-1 can be used for the research of prostate cancers .
Cat. No.: HY-183602
Target:
Research Areas:
FRC-303 is a CHD1 inhibitor with a Kd of 0.14 μM and an IC50 of 0.18 μM. FRC-303 binds to the H3K4me3 binding site of CHD1 tandem chromodomain, forms aromatic cage interactions and extended ligand contacts, acts as a methyl-lysine mimic, and occupies natural peptide ligand-binding regions. FRC-303 can be used for the research of prostate cancer .
Cat. No.: HY-P71588
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CHD1L; Chromo Domain-Containing Protein 1-Like; chromodomain Helicase DNA Binding Protein 1 Like; Amplified In Liver Cancer Protein 1; ALC1; Amplified In Liver Cancer 1; chromodomain-Helicase-DNA-Binding Protein 1-Like; CHDL; ATP-Dependent Chromatin Remod
Species:
Human
Source:
E. coli
Cat. No.: HY-P81264A
Synonyms: 2600010P09Rik; AF020312; ATP-dependent helicase Chd3; CHD3_HUMAN; chromodomain-helicase-DNA-binding protein 3; MGC40857; Mi 2a; Mi-2 autoantigen 240 kDa protein; Mi2-alpha; Prp7; Prp9 1; ZFH; Zinc finger helicase; hZFH; zinc-finger helicase (Snf2-like)
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
