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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
MRCK
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "MRCK" in MCE Product Catalog:
80
80 Publications Verification
Target:
Research Areas:
Chroman 1 is a highly potent and selective ROCK inhibitor. Chroman 1 is more potent against ROCK2 (IC50=1 pM) than ROCK1 (IC50=52 pM). Chroman 1 also has inhibitory activity against MRCK, with an IC50 of 150 nM .
80
80 Publications Verification
Cat. No.: HY-15392A
Purity: 99.11%
Target:
Research Areas:
Chroman 1 dihydrochloride is a highly potent and selective ROCK inhibitor. Chroman 1 dihydrochloride is more potent against ROCK2 (IC50=1 pM) than ROCK1 (IC50=52 pM).
Chroman 1 dihydrochloride also has inhibitory activity against MRCK, with an IC50 of 150 nM .
3
3 Cited Publications
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BDP9066 is a potent and selective myotonic dystrophy-related Cdc42-binding kinase MRCK inhibitor with an IC50 of 64 nM for MRCKβ in SCC12 cells, Ki values of 0.0136 nM and 0.0233 nM for MRCKα/β in house determinations, respectively. BDP9066 has therapeutic effect on skin cancer by reducing substrate phosphorylation.
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DJ4 is a ATP-competitive inhibitor of ROCK1/2 (IC50 values:5 and 50 nM) and MRCKα/β (IC50 values:10 and 100 nM). DJ4 blocks stress fiber formation and inhibits migration and invasion of cancer cells. DJ4 can be used for study of lung cancer, breast cancer, and pancreatic (PANC-1) cancer .
Cat. No.: HY-111423
CAS No.: 2226507-05-5
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Research Areas:
BDP8900 is a potent and selective inhibitor of myotonic dystrophy-related Cdc42-binding kinases (MRCKα and MRCKβ). BDP8900 reduces substrate phosphorylation, leading to morphological changes, motility inhibition and invasiveness of cancer cells .
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(R)-BDP9066 is an isomer of BDP9066 and has lower activity compared to BDP9066. BDP9066 is a potent inhibitor of myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK). (R)-BDP9066 is derived from patent WO2019034890A1 (E118) .
Cat. No.: HY-RS02301
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Research Areas:
CDC42BPA Human Pre-designed siRNA Set A contains three designed siRNAs for CDC42BPA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-111424R
CAS No.: 2226507-04-4
Research Areas:
BDP9066 (Standard) is the analytical standard of BDP9066 (HY-111424). This product is intended for research and analytical applications. BDP9066 is a potent and selective myotonic dystrophy-related Cdc42-binding Kinase MRCK inhibitor with an IC50 of 64 nM for MRCKβ in SCC12 cells, Ki values of 0.0136 nM and 0.0233 nM for MRCKα/β in house determinations, respectively. BDP9066 has therapeutic effect on sKin cancer by reducing substrate phosphorylation.
Cat. No.: HY-P810947
Synonyms: KIAA0451, CDC42BPA, Serine/threonine-protein kinase MRCK alpha, CDC42-binding protein kinase alpha, DMPK-like alpha, Myotonic dystrophy kinase-related CDC42-binding kinase alpha, MRCK alpha, Myotonic dystrophy protein kinase-like alpha
Cat. No.: HY-P811207
Synonyms: KIAA1124, CDC42BPB, Serine/threonine-protein kinase MRCK beta, CDC42-binding protein kinase beta, DMPK-like beta, Myotonic dystrophy kinase-related CDC42-binding kinase beta, CDC42BP-beta, MRCK beta, Myotonic dystrophy protein kinase-like beta
Cat. No.: HY-P702634
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: CDC42BPG; Myotonic Dystrophy Protein Kinase-Like Alpha; CDC42 Binding Protein Kinase Gamma; Myotonic Dystrophy Protein Kinase-Like Gamma; DMPK2; Serine/Threonine-Protein Kinase MRCK Gamma; MRCKgamma; DMPK-Like Gamma; Kappa-200; MRCK Gamma; HSMDPKIN; MRCKG
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P812039
Synonyms: KIAA0451, CDC42BPA, Serine/threonine-protein kinase MRCK alpha, CDC42-binding protein kinase alpha, DMPK-like alpha, Myotonic dystrophy kinase-related CDC42-binding kinase alpha, MRCK alpha, Myotonic dystrophy protein kinase-like alpha
Cat. No.: HY-P702635
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: CDC42BPB; CDC42-Binding Protein Kinase Beta; CDC42 Binding Protein Kinase Beta; CDC42BP-Beta; Myotonic Dystrophy Kinase-Related CDC42-Binding Kinase Beta; MRCK Beta; Serine/Threonine-Protein Kinase MRCK Beta; CDC42-Binding Protein Kinase Beta (DMPK-Like)
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P812039A
Synonyms: KIAA0451, CDC42BPA, Serine/threonine-protein kinase MRCK alpha, CDC42-binding protein kinase alpha, DMPK-like alpha, Myotonic dystrophy kinase-related CDC42-binding kinase alpha, MRCK alpha, Myotonic dystrophy protein kinase-like alpha
Cat. No.: HY-P705758
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: CDC42BPB; CDC42-Binding Protein Kinase Beta; CDC42 Binding Protein Kinase Beta; CDC42BP-Beta; Myotonic Dystrophy Kinase-Related CDC42-Binding Kinase Beta; MRCK Beta; Serine/Threonine-Protein Kinase MRCK Beta; CDC42-Binding Protein Kinase Beta (DMPK-Like)
Species:
Human
Source:
sf9 insect cells
Cat. No.: HY-15392R
CAS No.: 1273579-40-0
Target:
Research Areas:
Chroman 1 (Standard) is the analytical standard of Chroman 1 (HY-15392). This product is intended for research and analytical applications. Chroman 1 is a highly potent and selective ROCK inhibitor. Chroman 1 is more potent against ROCK2 (IC50=1 pM) than ROCK1 (IC50=52 pM). Chroman 1 also has inhibitory activity against MRCK, with an IC50 of 150 nM .
Cat. No.: HY-111424AR
CAS No.: 2284549-25-1
Research Areas:
(R)-BDP9066 (Standard) is the analytical standard of (R)-BDP9066 (HY-111424A). This product is intended for research and analytical applications. (R)-BDP9066 is an isomer of BDP9066 and has lower activity compared to BDP9066. BDP9066 is a potent inhibitor of myotonic dystrophy Kinase-related Cdc42-binding Kinase (MRCK). (R)-BDP9066 is derived from patent WO2019034890A1 (E118) .
Cat. No.: HY-P701817
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDC42BPA; Myotonic Dystrophy Kinase-Related CDC42-Binding Protein Kinase Alpha; CDC42 Binding Protein Kinase Alpha; Myotonic Dystrophy Kinase-Related CDC42-Binding Kinase Alpha; Serine/Threonine-Protein Kinase MRCK Alpha; Myotonic Dystrophy Kinase-Related
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
