25 Results for "

MSA

" in MedChemExpress (MCE) Product Catalog:
Products (25)

25 Results for "MSA" in MCE Product Catalog:

36
MSA-2
MSA-2
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36 Publications Verification
Cat. No.: HY-136927
CAS No.: 129425-81-6
Purity:  99.81%
Target:  

STING

Research Areas:  

Inflammation/Immunology Cancer

MSA-2, a potent and orally available non-nucleotide STING agonist, is bound to STING as a noncovalent dimer with nanomolar affinity. MSA-2 shows EC50s of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. MSA-2 stimulates interferon-β secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models .
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10
Epothilone B
Epothilone B
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10 Cited Publications
Cat. No.: HY-17029
CAS No.: 152044-54-7
Synonyms: EPO 906; Patupilone
Target:  

Microtubule/Tubulin Fungal Apoptosis Antibiotic Bacterial

Research Areas:  

Infection Cancer

Epothilone B is a microtubule stabilizer (MSA) with a Ki of 0.71μM, and is a MSA with blood-brain barrier permeability. Epothilone B acts by binding to the αβ-tubulin heterodimer subunit which causes decreasing of αβ-tubulin dissociation .
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1
MSA-2 dimer
MSA-2 dimer
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1 Cited Publications
Cat. No.: HY-141514
CAS No.: 2377881-92-8
Purity:  99.88%
Target:  

STING

Research Areas:  

Inflammation/Immunology Cancer

MSA-2 dimer is a selective, orally active non-nucleotide STING agonist (Kd=145 μM) with long-term antitumor and immunogenic activity. MSA-2 dimer is bound to STING as a non-covalent dimer exhibiting higher permeability than cyclic dinucleotide .
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MSA Protein
MSA Protein
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Cat. No.: HY-NP0204
Synonyms: Mouse Serum Albumin
MSA Protein (Mouse Serum Albumin) is most abundant protein in plasma, which leaks into the brain parenchyma when the blood-brain barrier (BBB) is impaired. Mouse Serum Albumin induces astrocytes to A1 phenotype to remarkably increase levels of Elovl1. Mouse Serum Albumin promotes VLSFAs secretion and causes neuronal lippoapoptosis through endoplasmic reticulum stress response pathway. MSA-activated microglia triggeres remarkable tau phosphorylation at multiple sites (Ser202/Thr205) through NLRP3 inflammasome pathway. Mouse Serum Albumin decreases the spatial learning and memory abilities in mice. Mouse Serum Albumin can be used for the study of neurodegenerative diseases like Alzheimer’s disease (AD) and frontotemporal dementia (FTD) .
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BacPROTAC-1
BacPROTAC-1
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Cat. No.: HY-153575
Target:  

PROTACs Bacterial

Research Areas:  

Infection

BacPROTAC-1 is a BacPROTAC degrader that induces the degradation of the target protein mSA by recruiting ClpC/ClpC1. BacPROTAC-1 binds to mSA, Bacillus subtilis ClpCNTD and Mycobacterium smegmatis ClpC1NTD with Kd values of 3.9, 2.8 and 0.69 μM, respectively. BacPROTAC-1 forms a ternary complex between the substrate and ClpC, promotes ClpC reassembly and activation, and induces ATP-dependent degradation of mSA and mSA fusion model substrates via the ClpCP or ClpC1P1P2 protease system. BacPROTAC-1 can be used in studies on bacterial targeted protein degradation, bacterial protein homeostasis and antibacterial target discovery .
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MSA-2-Pt
MSA-2-Pt
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Cat. No.: HY-162133
CAS No.: 3028778-96-0
Target:  

STING Apoptosis IKK IFNAR NF-κB

Research Areas:  

Cancer

MSA-2-Pt, platinum salt-modified MSA-2 (HY-136927), is a STING agonist. MSA-2-Pt inducing cell
death by platinum and activating the STING pathway by MSA-2. MSA-2-Pt direct activates STING pathway, induces phosphorylation of TBK1, IRF3, and NF-κB p65. MSA-2-Pt enhances tumor infiltration of CD4 + and CD8 + T cells, and induces tumor cell death and apoptosis in mouse colon carcinoma and melanoma models .
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Methyl sinapate
Methyl sinapate
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Cat. No.: HY-N3265
CAS No.: 20733-94-2
Synonyms: MSA
Category:  

Microorganisms Monophenols Phenols

Target:  

Others

Methyl sinapate (MSA), a hydroxycinnamic acid, is a natural UV screening agent .
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STING agonist-47
STING agonist-47
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Cat. No.: HY-178338
Target:  

STING

Research Areas:  

Cancer

STING agonist-47 is a STING agonist with an EC50 of 0.72 μM and a Kd of 176 nM. STING agonist-47 is a dimer of MSA-2 (HY-136927). STING agonist-47 can be used for the research of cancer, such as breast cancer .
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STING-IN-8
STING-IN-8
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Cat. No.: HY-163749
Target:  

STING

Research Areas:  

Inflammation/Immunology

STING-IN-8 (Compound 15b) emerges as a potent stimulator of interferon gene (STING) inhibitor with an IC50 value of 0.121 μM in human and an IC50 value of 0.033 μM in mouse. STING-IN-8 inhibits MSA-2 (HY-136927) or 2’, 3’ -cGAMP (HY-100564)-stimulated STING signaling and suppresses immune-inflammatory cytokine levels in both human and murine cells. STING-IN-8 is promising for research in the field of STING-associated inflammatory and autoimmune diseases .
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TPO Human Pre-designed siRNA Set A
TPO Human Pre-designed siRNA Set A
Cat. No.: HY-RS14941
Target:  

Small Interfering RNA (siRNA)

Research Areas:  

Others

TPO Human Pre-designed siRNA Set A contains three designed siRNAs for TPO gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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STING-IN-12
STING-IN-12
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Cat. No.: HY-173316
Target:  

STING

Research Areas:  

Inflammation/Immunology

STING-IN-12 (compound Y2) is an inhibitor of STING. STING-IN-12 inhibits IFNβ gene expression (IC50=0.75μM) induced by SR717. STING-IN-12 inhibits STING pathway activation induced by the STING agonist SR717 in THP1 cells and MSA-2-induced STING pathway activation in vivo in mice .
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FTY720-C2
FTY720-C2
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Cat. No.: HY-123439
CAS No.: 249289-10-9
Target:  

α-synuclein

Research Areas:  

Neurological Disease

FTY720-C2 is a derivative of FTY72 (HY-12005). FTY720-C2 promotes the expression of brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor (GDNF) in multiple system atrophy (MSA) models, without causing immunosuppression. FTY720-C2 improves motor dysfunction and reduces the levels of insoluble alpha-synuclein (αSyn) in MSA mouse models. FTY720-C2 is blood-brain barrier penetrate .
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MSA-2 (Standard)
MSA-2 (Standard)
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Cat. No.: HY-136927R
CAS No.: 129425-81-6
Target:  

Reference Standards STING

Research Areas:  

Inflammation/Immunology Cancer

MSA-2 (Standard) is the analytical standard of MSA-2 (HY-136927). This product is intended for research and analytical applications. MSA-2, a potent and orally available non-nucleotide STING agonist, is bound to STING as a noncovalent dimer with nanomolar affinity. MSA-2 shows EC50s of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. MSA-2 stimulates interferon-β secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models .
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Mal-PEG4-Val-Cit-PAB-MSA-2
Mal-PEG4-Val-Cit-PAB-MSA-2
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Cat. No.: HY-181992
Target:  

Drug-Linker Conjugates for ADC

Research Areas:  

Inflammation/Immunology Cancer

Mal-PEG4-Val-Cit-PAB-MSA-2 is a Drug-Linker Conjugates for ADC. Mal-PEG4-Val-Cit-PAB-MSA-2 consists of the ADC Cytotoxin MSA-2 (HY-136927) and a linker Mal-PEG4-Val-Cit-PAB-OH (HY-140143). Mal-PEG4-Val-Cit-PAB-MSA-2 can be used for synthesis of ADCs .
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Exo1 Mouse Pre-designed siRNA Set A
Exo1 Mouse Pre-designed siRNA Set A
Cat. No.: HY-RS20731
Target:  

Small Interfering RNA (siRNA)

Research Areas:  

Others

Exo1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Exo1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Thyroid Peroxidase Antibody (YA1480)
Thyroid Peroxidase Antibody (YA1480)
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Cat. No.: HY-P81735
Synonyms: MSA; TDH2A; TPO; TPX

Host:  

Rabbit

Application:  

WB, IHC-P, IP

Reactivity:  

Human

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WY165
WY165
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Cat. No.: HY-182964
Target:  

ClpP

Research Areas:  

Cardiovascular Disease Neurological Disease Metabolic Disease Cancer

WY165 is a bifunctional molecule comprising TR79, an activator of the mitochondrial protease complex caseinolytic protease P (ClpP), linked to desthiobiotin. WY165 mediates selective degradation of monomeric streptavidin (mSA) and its fusion proteins localized to the mitochondrial matrix with a DC50 of 197 nM. WY165 restores mitochondrial morphology by reducing the level of mSA fused to short transmembrane protein 1 (mSA-STMP1) in cells overexpressing mSA-STMP1. WY165 can be used for research in cancer, neurodegenerative diseases, cardiovascular diseases, and metabolic diseases .
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(E)-Methyl sinapate
(E)-Methyl sinapate
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Cat. No.: HY-N3265A
CAS No.: 42041-51-0
Synonyms: (E)-MSA
Category:  

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