30 Results for "

Measles

" in MedChemExpress (MCE) Product Catalog:
Products (30)

30 Results for "Measles" in MCE Product Catalog:

8
SKI II
SKI II
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8 Publications Verification
Cat. No.: HY-13822
CAS No.: 312636-16-1
Purity:  99.25%
Target:  

SphK Dihydroceramide Desaturase 1 (DES1) Apoptosis Reactive Oxygen Species (ROS) mTOR PERK Keap1-Nrf2

Research Areas:  

Infection Neurological Disease Cancer

SKI-II is an orally active dual-target inhibitor of SphK1/2 and DES1, with Ki values of 16 µM and 0.3 µM against SphK1 and DES1, respectively. SKI-II activates the PERK-Nrf2 antioxidant pathway by stabilizing Nrf2, and synergizes with Temozolomide (HY-17364) to induce oxidative/endoplasmic reticulum stress and cancer cell death under hypoxic conditions. In vivo, SKI-II inhibits SphK activity, promotes ceramide accumulation and apoptosis, and synergizes with Cisplatin (HY-17394) to reverse drug resistance via the ras/MAPK pathway. SKI-II reduces measles virus replication by inhibiting mTORC1 activity. SKI-II binds to VCP to induce M1 polarization, enhances host tolerance to Staphylococcus aureus infection, and exerts radioprotective effects through Nrf2 activation and accelerated DNA repair. SKI-II can be used in research related to glioblastoma, acute myeloid leukemia, gastric cancer, measles virus infection, Staphylococcus aureus infection, and acute radiation syndrome .
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ERDRP-0519
ERDRP-0519
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3 Cited Publications
Cat. No.: HY-102074
CAS No.: 1374006-96-8
Purity:  99.90%
Target:  

Measles Virus

Research Areas:  

Infection

ERDRP-0519, an orally bioavailable small-molecule Measles virus (MeV) polymerase inhibitor, prevents measles disease in squirrel monkeys (Saimiri sciureus). ERDRP-0519 inhibits morbilliviruses with nanomolar potency. .
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Tenuazonic acid
Tenuazonic acid
0 Images
1 Cited Publications
Cat. No.: HY-N6715
CAS No.: 610-88-8
Category:  

Infection Microorganisms Ketones, Aldehydes, Acids Disease Research Fields Biological Pesticide Research Agricultural Research

Target:  

Influenza Virus Bacterial Enterovirus Photosystem II

Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD50 is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .
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Moroxydine hydrochloride
Moroxydine hydrochloride
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1 Cited Publications
Cat. No.: HY-B0420A
CAS No.: 3160-91-6
Synonyms: ABOB hydrochloride
Target:  

Influenza Virus HCV HSV Apoptosis Caspase

Research Areas:  

Infection

Moroxydine (ABOB) hydrochloride is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine hydrochloride exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine hydrochloride blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine hydrochloride significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels .
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AS-136A
AS-136A
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Cat. No.: HY-134909
CAS No.: 949898-66-2
Purity:  99.67%
Target:  

DNA/RNA Synthesis

Research Areas:  

Infection

AS-136A is an orally active non-nucleoside inhibitor of the measles virus RNA-dependent RNA polymerase (RdRp) with an IC50 of 2 µM for measles virus .
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hDHODH-IN-3
hDHODH-IN-3
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Cat. No.: HY-135570
CAS No.: 1644156-80-8
Purity:  99.97%
Target:  

Influenza Virus Dihydroorotate Dehydrogenase DNA/RNA Synthesis

Research Areas:  

Infection

hDHODH-IN-3 (compound 21d) is a human dihydroorotate dehydrogenase (HsDHODH) inhibitor, inhibits measles virus replication with a pMIC50 value of 8.6 .
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hDHODH-IN-4
hDHODH-IN-4
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Cat. No.: HY-128787
CAS No.: 1644156-56-8
Purity:  99.73%
Target:  

Dihydroorotate Dehydrogenase DNA/RNA Synthesis Influenza Virus

Research Areas:  

Infection

hDHODH-IN-4 is a potent human dihydroorotate dehydrogenase (DHODH) inhibitor, with a pIC50 of 7.8 for human recombinant DHODH. hDHODH-IN-4 inhibits measles virus replication, with a pMIC50 of 8.8 .
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Tenuazonic acid-d13
Tenuazonic acid-d13
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Cat. No.: HY-W653921
CAS No.: 2714417-30-6
Tenuazonic acid-d13 is deuterium labeled Tenuazonic acid. Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD50 is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .
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Myramistin
Myramistin
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Cat. No.: HY-103658
CAS No.: 15809-19-5
Synonyms: Miramistin
Target:  

Bacterial HIV Influenza Virus Measles Virus

Research Areas:  

Infection

Myramistin (Miramistin) is a cationic surfactant and disinfectant preservative. Myramistin exhibits high bactericidal activity against Staphylococcus aureus and Escherichia coli, shows lower activity against yeasts and fungi, and is active against HIV, measles virus, mumps virus, as well as influenza viruses of the H3N2 and H5N1 subtypes. Myramistin adsorbs to the negatively charged microbial cell membrane, leading to increased membrane permeability and disruption of membrane integrity, which ultimately results in leakage of intracellular contents, enzyme inactivation, and the death of bacteria/fungi/enveloped viruses .
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Tenuazonic acid (Standard)
Tenuazonic acid (Standard)
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Cat. No.: HY-N6715R
CAS No.: 610-88-8
Category:  

Microorganisms Ketones, Aldehydes, Acids

Target:  

Reference Standards Influenza Virus Bacterial Enterovirus Photosystem II

Tenuazonic acid (Standard) is the analytical standard of Tenuazonic acid. This product is intended for research and analytical applications. Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD50 is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .
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MeV-IN-1
MeV-IN-1
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Cat. No.: HY-117121
CAS No.: 313527-44-5
Synonyms: OX-1
Target:  

Measles Virus

Research Areas:  

Infection

MeV-IN-1 (OX-1) is a specific entry inhibitor targeting measles virus (MeV), with an IC50 value of 100 μM. MeV-IN-1 exhibits inhibitory activity against live MeV-Edm virus. MeV-IN-1 effectively suppresses the formation of infection foci. MeV-IN-1 can be used in studies related to measles virus infection .
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Selenazofurin
Selenazofurin
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Cat. No.: HY-106685
CAS No.: 83705-13-9
Synonyms: CI 935
Target:  

Influenza Virus

Research Areas:  

Infection

Selenazofurin is an antiviral compound used against influenza A and influenza B viruses. Selenazofurin shows antiviral activity in cells against Measles, Para-3, Mumps, VV, HSV-2 with the ED50s of 3.7 μg/ml, 1.3 μg/ml, 8.0 μg/ml, 3.4 μg/ml, 4.3 μg/ml .
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GHP-88309
GHP-88309
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Cat. No.: HY-170395
CAS No.: 1269267-87-9
Target:  

RSV DNA/RNA Synthesis

Research Areas:  

Infection

GHP-88309 is a broad-spectrum, orally active antiviral agent targeting paramyxoviruses, that targets the viral polymerase, interupts the viral RNA synthesis, and inhibits respiratory syncytial virus (RSV), measles virus (MeV), and canine distemper virus (CDV) with EC50 of 0.06-1.2 μM. GHP-88309 exhibits anti-infectious efficacy in mouse models .
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Antiviral agent 64
Antiviral agent 64
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Cat. No.: HY-N15215
CAS No.: 1004319-60-1
Category:  

Monophenols Zingiberaceae Extract Phenols 500 - Internal Server Error | MedChemExpress

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