145

5-Azacytidine

145 Publications Verification

Cat. No.: HY-10586

CAS No.: 320-67-2

Purity: 99.91%

Synonyms: Azacitidine; 5-AzaC; Ladakamycin

Target:

Organoid Nucleoside Antimetabolite/Analog DNA Methyltransferase Bacterial Autophagy Antibiotic

Research Areas:

Infection Cancer

5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated into DNA to covalently trap DNA methyltransferases and contributes to reverse epigenetic changes . 5-Azacytidine induces cell autophagy .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

30

Bobcat339

30 Cited Publications

Cat. No.: HY-111558

CAS No.: 2280037-51-4

Purity: 99.44%

Target:

DNA Methyltransferase TET Protein

Research Areas:

Cancer

Bobcat339 is a potent and selective cytosine-based inhibitor of TET enzyme, with IC₅₀s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

30

Bobcat339 hydrochloride

30 Cited Publications

Cat. No.: HY-111558A

CAS No.: 2436747-44-1

Purity: 99.59%

Target:

DNA Methyltransferase TET Protein

Research Areas:

Cancer

Bobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of TET enzyme, with the IC₅₀s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 hydrochloride is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

21

GSK3368715

21 Cited Publications

Cat. No.: HY-128717

CAS No.: 1629013-22-4

Purity: 99.19%

Synonyms: EPZ019997

Target:

Histone Methyltransferase

Research Areas:

Cancer

GSK3368715 (EPZ019997) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC₅₀=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 (EPZ019997) produces a shift in arginine methylation states, alters exon usage, and has strong anti-cancer activity .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

21

GSK3368715 dihydrochloride

21 Cited Publications

Cat. No.: HY-128717A

CAS No.: 1628925-77-8

Purity: 99.96%

Synonyms: EPZ019997 dihydrochloride

Target:

Histone Methyltransferase

Research Areas:

Cancer

GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC₅₀=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) produces a shift in arginine methylation states, alters exon usage, and has strong anti-cancer activity .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

16

Clindamycin hydrochloride monohydrate

16 Cited Publications

Cat. No.: HY-N7118

CAS No.: 58207-19-5

Target:

Bacterial Antibiotic

Research Areas:

Infection Cancer

Clindamycin hydrochloride monohydrate is an oral protein synthesis inhibitory agent that has the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin hydrochloride monohydrate resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin hydrochloride monohydrate decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla) .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

16

Clindamycin

16 Cited Publications

Cat. No.: HY-B1455

CAS No.: 18323-44-9

Target:

Bacterial Antibiotic Parasite

Research Areas:

Infection Cancer

Clindamycin is an orally active and broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin can inhibit bacterial protein synthesis, possessing the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla). Clindamycin also can be used for researching malaria .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

15

GSK-3685032

15 Cited Publications

Cat. No.: HY-139664

CAS No.: 2170137-61-6

Purity: 99.95%

Target:

DNA Methyltransferase

Research Areas:

Cancer

GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1-selective inhibitor, with an IC₅₀ of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

15

RG108

15 Cited Publications

Cat. No.: HY-13642

CAS No.: 48208-26-0

Purity: 99.93%

Synonyms: N-Phthalyl-L-tryptophan

Target:

DNA Methyltransferase

Research Areas:

Inflammation/Immunology Cancer

RG108 (N-Phthalyl-L-tryptophan) is a non-nucleoside DNA methyltransferases (DNMTs) inhibitor (IC₅₀=115 nM) that blocks the DNMTs active site. RG108 (N-Phthalyl-L-tryptophan) causes demethylation and reactivation of tumor suppressor genes, but it does not affect the methylation of centromeric satellite sequences .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

13

EPZ020411

13 Cited Publications

Cat. No.: HY-12970

CAS No.: 1700663-41-7

Purity: 98.07%

Target:

Histone Methyltransferase Reactive Oxygen Species (ROS) Apoptosis

Research Areas:

Neurological Disease Cancer

EPZ020411 is a selective, blood-brain barrier-permeable PRMT6 inhibitor with an IC₅₀ of 0.010 μM. EPZ020411 blocks PRMT6-mediated histone H3R2 methylation, reduces ROS production, and inhibits Apoptosis. EPZ020411 is applicable to research related to neuropathic pain, colorectal cancer, ototoxicity, hearing loss and glioblastoma .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

13

EPZ020411 hydrochloride

13 Cited Publications

Cat. No.: HY-12970A

CAS No.: 2070015-25-5

Purity: 98.15%

Target:

Histone Methyltransferase Reactive Oxygen Species (ROS) Apoptosis

Research Areas:

Neurological Disease Cancer

EPZ020411 hydrochloride is a selective, blood-brain barrier-permeable PRMT6 inhibitor with an IC₅₀ of 0.010 μM. EPZ020411 hydrochloride blocks PRMT6-mediated histone H3R2 methylation, reduces ROS production, and inhibits Apoptosis. EPZ020411 hydrochloride is applicable to research related to neuropathic pain, colorectal cancer, ototoxicity, hearing loss and glioblastoma .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

11

Cycloleucine

11 Cited Publications

Cat. No.: HY-30008

CAS No.: 52-52-8

Target:

iGluR

Research Areas:

Infection Neurological Disease Metabolic Disease Cancer

Cycloleucine is a specific inhibitor of S-adenosyl-methionine mediated methylation. Cycloleucine is antagonist of NMDA receptor associated glycine receptor, with a K_i of 600 μM. Cycloleucine is also a competitive inhibitor of ATP: L-methionine-S-adenosyl transferase in vitro. Cycloleucine has anxiolytic and cytostatic effects .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

11

Cladribine

11 Cited Publications

Cat. No.: HY-13599

CAS No.: 4291-63-8

Purity: 99.97%

Synonyms: 2-Chloro-2′-deoxyadenosine; CldAdo; 2CdA

Target:

Adenosine Deaminase Apoptosis

Research Areas:

Cardiovascular Disease Cancer

Cladribine (2-Chloro-2′-deoxyadenosine), a purine nucleoside analog, is an orally active adenosine deaminase inhibitor. Cladribine functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. Cladribine can inhibit DNA methylation. Cladribine has anti-lymphoma activity. Cladribine can be used for the research of several hematologic malignancies and multiple sclerosis .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

9

TMS1/ASC Antibody

9 Cited Publications

Cat. No.: HY-P80548

Synonyms: PYCARD; ASC; CARD5; TMS1; Apoptosis-associated speck-like protein containing a CARD; hASC; Caspase recruitment domain-containing protein 5; PYD and CARD domain-containing protein; Target of Methylation-induced silencing 1

Host:

Rabbit

Application:

WB, IHC-F, IHC-P, ICC/IF, ELISA

Reactivity:

Human, Mouse, Rat

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

9

KDOAM-25 citrate

9 Cited Publications

Cat. No.: HY-102047B

CAS No.: 2448475-08-7

Purity: 98.11%

Target:

Histone Demethylase

Research Areas:

Cancer

KDOAM-25 citrate is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor with IC₅₀s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 citrate increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

7

Betaine chloride

7 Cited Publications

Cat. No.: HY-N0739

CAS No.: 590-46-5

Category:

Ketones, Aldehydes, Acids Other Diseases Chenopodiaceae Extract 500 - Internal Server Error | MedChemExpress

country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Cart

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Oops!

Sorry, Something went wrong on our server.
Our team has been notified and is working to fix the issue.