183

Docetaxel

183 Publications Verification

Cat. No.: HY-B0011

CAS No.: 114977-28-5

Synonyms: RP-56976

Category:

Terpenoids Diterpenoids Endogenous metabolite Disease Research Fields Cancer

Target:

Microtubule/Tubulin Cytochrome P450 Apoptosis Drug Derivative

Docetaxel (RP-56976) is an orally active tubulin stabilizer with antitumor activity. Docetaxel is a P-glycoprotein substrate and is metabolized by CYP3A to inactive products. Docetaxel binds tubulin, promotes tubulin polymerization, and inhibits microtubule depolymerization. Docetaxel induces aberrant mitosis followed by necrotic-like cell death at low concentrations, and induces G2/M mitotic arrest and drives apoptosis at high concentrations. Docetaxel induces renal injury/renal alterations, sex-dependent granule toxicity/uptake, low cardiac delivery, and decreased hepatic SOD/increased catalase/hepatotoxicity. Docetaxel can be used in cancer-related research .

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183

Docetaxel Trihydrate

183 Publications Verification

Cat. No.: HY-B0011A

CAS No.: 148408-66-6

Synonyms: RP-56976 Trihydrate

Target:

Microtubule/Tubulin Cytochrome P450 Apoptosis Drug Derivative

Research Areas:

Cancer

Docetaxel Trihydrate (RP-56976 Trihydrate) is an orally active tubulin stabilizer with antitumor activity. Docetaxel Trihydrate is a P-glycoprotein substrate and is metabolized by CYP3A to inactive products. Docetaxel Trihydrate binds tubulin, promotes tubulin polymerization, and inhibits microtubule depolymerization. Docetaxel Trihydrate induces aberrant mitosis followed by necrotic-like cell death at low concentrations, and induces G2/M mitotic arrest and drives apoptosis at high concentrations. Docetaxel Trihydrate induces renal injury/renal alterations, sex-dependent granule toxicity/uptake, low cardiac delivery, and decreased hepatic SOD/increased catalase/hepatotoxicity. Docetaxel Trihydrate can be used in cancer-related research .

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135

Nocodazole

135 Cited Publications

Cat. No.: HY-13520

CAS No.: 31430-18-9

Purity: 99.59%

Synonyms: Oncodazole; R17934

Target:

Bcr-Abl Autophagy Microtubule/Tubulin Apoptosis Mitosis

Research Areas:

Cancer

Nocodazole (Oncodazole) is a rapidly-reversible inhibitor of microtubule. Nocodazole binds to β-tubulin and disrupts microtubule assembly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl.

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25

Molibresib besylate

25 Cited Publications

Cat. No.: HY-13032B

CAS No.: 1895049-20-3

Purity: 97.04%

Synonyms: GSK 525762C; I-BET 762 besylate

Target:

Epigenetic Reader Domain ERK

Research Areas:

Cancer

Molibresib besylate (GSK 525762C; I-BET 762 besylate) is an orally active pan-BET inhibitor that targets and binds to BRD2, BRD3, BRD4 and BRDT. By competitively occupying acetylated lysine binding sites, Molibresib besylate disrupts the interaction between BET proteins and chromatin, thereby effectively inhibiting MYC expression and target gene transcription. Molibresib besylate exhibits broad antiproliferative activity, which not only inhibits cancer cell growth and induces growth arrest, but also downregulates mitosis-related genes and upregulates the level of p-ERK1/2. When combined with MEK inhibitors, Molibresib besylate shows a significant synergistic effect, reduces tumor burden in mouse models of leukemia, modulates the immune microenvironment and prolongs survival. Molibresib besylate is widely applicable to research related to acute myeloid leukemia, multiple myeloma, triple-negative breast cancer, small-cell lung cancer and various advanced refractory solid tumors .

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11

Apcin

11 Cited Publications

Cat. No.: HY-110287

CAS No.: 300815-04-7

Purity: 99.62%

Target:

APC Mitosis

Research Areas:

Cancer

Apcin, a ligand of Cdc20, is a potent and competitive anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity inhibitor. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. Apcin occupes the D-box-binding pocket on the side face of the WD40-domain and can prolong mitosis .

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6

TAO Kinase inhibitor 1

6 Cited Publications

Cat. No.: HY-112136

CAS No.: 850467-66-2

Purity: 99.81%

Synonyms: CP 43

Target:

MAP3K Mitosis

Research Areas:

Cancer

TAO Kinase inhibitor 1 (compound 43) is a selective, ATP-competitive thousand-and-one amino acid kinases (TAOK) inhibitor with IC₅₀s of 11 to 15 nM for TAOK1 and 2, respectively. TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death .

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6

P62-mediated mitophagy inducer

6 Cited Publications

Cat. No.: HY-115576

CAS No.: 1809031-84-2

Purity: 99.54%

Target:

p62 Mitophagy Autophagy Mitosis

Research Areas:

Neurological Disease Cancer

P62-mediated mitophagy inducer (PMI) is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mitochondrial autophagy without recruitment of Parkin or collapse of the mitochondrial membrane potential and remains active in cells lacking a fully functional PINK1/Parkin pathway. P62-mediated mitophagy inducer serves as a pharmacological tool to study the molecular mechanisms of mitosis, avoiding toxicity and some of the non-specific effects associated with the sudden dissipation of mitochondria lacking membrane potential .

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5

Disitamab vedotin

5 Cited Publications

Cat. No.: HY-P9985

CAS No.: 2136633-23-1

Synonyms: RC48

Target:

Antibody-Drug Conjugates (ADCs) EGFR

Research Areas:

Cancer

Disitamab vedotin (RC48) is a HER2-targeted antibody-drug conjugate (ADC), formed by conjugation of the humanized anti-HER2 antibody Disitamab (HY-P99854) with drug-linker VcMMAE (HY-15575). VcMMAE consists of a cleavable MC-Val-Cit-PAB linker and the microtubule inhibitor MMAE (HY-15162). After binding to HER2 and undergoing endocytosis, Disitamab vedotin releases MMAE in lysosomes, which further inhibits microtubule assembly, arrests mitosis and induces apoptosis, while also exerting a bystander effect. Disitamab vedotin can be used in studies of HER2-positive breast cancer .

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4

ON1231320

4 Cited Publications

Cat. No.: HY-100789

CAS No.: 1312471-39-8

Purity: 99.90%

Target:

Apoptosis Polo-like Kinase (PLK) Mitosis

Research Areas:

Cancer

ON1231320 is a highly specific polo like kinase 2 (PLK2) inhibitor with an IC₅₀ of 0.31 μM. ON1231320 blocks tumor cell cycle progression in the G2/M phase in mitosis, causing apoptotic cell death. ON1231320, an arylsulfonyl pyrido-pyrimidinone, has antitumor activity .

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3

1-Oleoyl lysophosphatidic acid sodium

3 Cited Publications

Cat. No.: HY-107614

CAS No.: 325465-93-8

Purity: 99.80%

Synonyms: 1-Oleoyl-sn-glycero-3-phosphate sodium; 1-Oleoyl-LPA sodium; 18:1 Lyso PA sodium

Target:

LPL Receptor Mitosis

Research Areas:

Neurological Disease

1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) sodium, a potent bioactive phospholipid, is a LPA receptor activator. 1-Oleoyl lysophosphatidic acid sodium can promote mitosis by inducing DNA synthesis. 1-Oleoyl lysophosphatidic acid sodium is also involved in normal and pathological emotional responses, including anxiety and depression .

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3

AG126

3 Cited Publications

Cat. No.: HY-108330

CAS No.: 118409-62-4

Purity: ≥98.0%

Synonyms: Tyrphostin AG126

Target:

ERK Mitosis

Research Areas:

Inflammation/Immunology

AG126 is a tyrosine kinase inhibitor, can inhibit the phosphorylation of ERK1 and ERK2 at 25-50 μM. AG126 can be used in meiosis, mitosis, and postmitotic research .

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3

Litronesib

3 Cited Publications

Cat. No.: HY-14846

CAS No.: 910634-41-2

Purity: 99.35%

Synonyms: LY2523355

Target:

Kinesin Mitosis

Research Areas:

Cancer

Litronesib (LY2523355) is a selective mitosis-specific kinesin Eg5 inhibitor, with antitumor activity .

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3

MELK-8a

3 Cited Publications

Cat. No.: HY-100368

CAS No.: 1922153-17-0

Purity: 98.32%

Synonyms: NVS-MELK8a

Target:

PDGFR Haspin Kinase MELK Mitosis

Research Areas:

Cancer

MELK-8a (NVS-MELK8a) is a highly potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor with IC₅₀ of 2 nM. MELK-8a also inhibits Flt3 (ITD), Haspin, PDGFRα with IC₅₀s of 0.18, 0.19, and 0.42 μM, respectively. MELK plays an essential role in regulating cell mitosis in a subset of cancer cells .

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2

Ethofumesate

2 Cited Publications

Cat. No.: HY-136369

CAS No.: 26225-79-6

Purity: 95.31%

Target:

Environmental Pollutants Herbicide

Research Areas:

Others

Ethofumesate, a chiral herbicide, acts by inhibiting mitosis and reducing photosynthesis and plant respiration .

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1

FT709

1 Cited Publications

Cat. No.: HY-145967

CAS No.: 2413991-74-7

Purity: 98.03%

Target:

Deubiquitinase Mitosis

Research Areas:

Cancer

FT709 is a potent and selective USP9X inhibitor, an IC₅₀ of 82 nM. USP9X has been linked with centrosome function, chromosome alignment during mitosis, EGF receptor degradation, chemo-sensitization, and circadian rhythms .

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1

Estramustine phosphate sodium

1 Cited Publications

Cat. No.: HY-13627

CAS No.: 52205-73-9

Purity: 99.42%

Target:

Apoptosis Microtubule/Tubulin Mitosis

Research Areas:

Inflammation/Immunology Endocrinology Cancer

Estramustine phosphate sodium, an estradiol analog, is an orally active antimicrotubule chemotherapy agent. Estramustine phosphate sodium depolymerises microtubules by binding to microtubule associated proteins (MAPs) and/or to tubulin. Estramustine phosphate sodium can interfere mitosis, trigger cell death and induce apoptosis, which can be used for the research of cancer like prostate cancer .

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1

Tubulysin A

1 Cited Publications

Cat. No.: HY-15995

CAS No.: 205304-86-5

Synonyms: TubA

Target:

Antibiotic Microtubule/Tubulin ADC Payloads Mitosis

Research Areas:

Cancer

Tubulysin A (TubA) is an anticancer and antiangiogenic agent with anti-microtubule, anti-mitosis and anti-proliferative activity against a variety of cancer cells with IC₅₀ values in the pmol range. It can induce apoptosis of cancer cells and has no effect on normal cells. Tubulysins are a group of potent cytotoxins consisting of nine members (A-I). Tubulysin A can synthesize ADC as ADC Cytotoxin .

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1

Harmol

1 Cited Publications

Cat. No.: HY-107811

CAS No.: 487-03-6

Purity: 99.76%

Category:

Neurological Disease Zygophyllaceae Extract 500 - Internal Server Error | MedChemExpress

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