122

Telaglenastat

122 Publications Verification

Cat. No.: HY-12248

CAS No.: 1439399-58-2

Purity: 99.82%

Synonyms: CB-839

Target:

Glutaminase Autophagy

Research Areas:

Cancer

Telaglenastat (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC₅₀s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat inuduces autophagy and has antitumor activity .

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122

Telaglenastat hydrochloride

122 Publications Verification

Cat. No.: HY-12248A

CAS No.: 1874231-60-3

Synonyms: CB-839 hydrochloride

Target:

Glutaminase Autophagy

Research Areas:

Cancer

Telaglenastat (CB-839) hydrochloride is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat hydrochloride selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC₅₀s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat hydrochloride inudces autophagy and has antitumor activity .

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30

Grazoprevir

30 Cited Publications

Cat. No.: HY-15298

CAS No.: 1350514-68-9

Purity: 99.99%

Synonyms: MK-5172

Target:

HCV Protease HCV SARS-CoV

Research Areas:

Infection

Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with K_is of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively . Grazoprevir inhibits SARS-CoV-2 3CL ^pro activity .

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30

Grazoprevir potassium salt

30 Cited Publications

Cat. No.: HY-15298A

CAS No.: 1206524-86-8

Purity: 99.63%

Synonyms: MK-5172 potassium salt

Target:

HCV HCV Protease SARS-CoV

Research Areas:

Infection

Grazoprevir potassium salt (MK-5172 potassium salt) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with K_is of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively . Grazoprevir potassium salt inhibits SARS-CoV-2 3CL ^pro activity .

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30

Grazoprevir hydrate

30 Cited Publications

Cat. No.: HY-15298B

CAS No.: 1350462-55-3

Purity: 99.99%

Synonyms: MK-5172 hydrate

Target:

HCV HCV Protease SARS-CoV

Research Areas:

Infection

Grazoprevir hydrate (MK-5172 hydrate) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with K_is of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively . Grazoprevir hydrate inhibits SARS-CoV-2 3CL ^pro activity .

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22

Daraxonrasib

22 Cited Publications

Cat. No.: HY-148439

CAS No.: 2765081-21-6

Purity: 99.68%

Synonyms: RMC-6236; RAS-IN-2

Target:

Ras PERK

Research Areas:

Cancer

Daraxonrasib (RMC-6236) is an orally active, non-covalent RAS (ON) inhibitor. Daraxonrasib disrupts the interaction of wild-type or mutant RAS proteins with the RAS binding domain of BRAF, with EC₅₀ values ranging from 28-220 nM for wild-type KRAS, NRAS, HRAS, and multiple oncogenic RAS variants. Daraxonrasib inhibits pERK. Daraxonrasib has anti-tumor activity against KRAS mutant tumors .

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20

RMC-7977

20 Cited Publications

Cat. No.: HY-156498

CAS No.: 2765082-12-8

Purity: 99.48%

Target:

Ras ERK Raf Ribosomal S6 Kinase (RSK) AMPK Apoptosis PARP

Research Areas:

Cancer

RMC-7977 is an orally active triple-complex RAS inhibitor that can simultaneously bind to cyclophilin A (CYPA) (K_d = 195 nM) and KRAS (G12V) (K_d = 292 μM). It exhibits broad-spectrum inhibitory activity against KRAS, NRAS, and HRAS proteins and their various wild-type and mutant variants. RMC-7977 induces apoptosis by inhibiting the phosphorylation of ERK, CRAF, and RSK, as well as increasing PARP cleavage. This leads to tumor regression, reduces resistance in KRAS ^G12C cancer models, and demonstrates good tolerability across various RAS cancer models .

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13

Mobocertinib

13 Cited Publications

Cat. No.: HY-135815

CAS No.: 1847461-43-1

Purity: 99.60%

Synonyms: TAK-788; AP32788

Target:

EGFR

Research Areas:

Cancer

Mobocertinib (TAK-788) is an orally active and irreversible EGFR/HER2 inhibitor. Mobocertinib potently inhibits oncogenic variants containing activating EGFRex20ins mutations with selectivity over wild-type EGFR. Mobocertinib can be used in NSCLC research .

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13

Mobocertinib succinate

13 Cited Publications

Cat. No.: HY-135815A

CAS No.: 2389149-74-8

Purity: 99.83%

Synonyms: TAK-788 succinate; AP32788 succinate

Target:

EGFR

Research Areas:

Cancer

Mobocertinib (TAK-788) succinate is an orally active and irreversible EGFR/HER2 inhibitor. Mobocertinib succinate potently inhibits oncogenic variants containing activating EGFRex20ins mutations with selectivity over wild-type EGFR. Mobocertinib succinate can be used in NSCLC research .

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11

Medroxyprogesterone

11 Cited Publications

Cat. No.: HY-B0648

CAS No.: 520-85-4

Synonyms: 17α-Hydroxy-6α-methylprogesterone; U8840

Target:

Progesterone Receptor

Research Areas:

Endocrinology Cancer

Medroxyprogesterone (17α-Hydroxy-6α-methylprogesterone) is a synthetic human variant of progesterone that is a progesterone receptor agonist with oral activity. Medroxyprogesterone can induce cell proliferation through the PI3K/Akt signaling pathway. Medroxyprogesterone has an inhibitory effect on atherosclerosis in mice. The progesterone agonist activity of Medroxyprogesterone is less effective than Medroxyprogesterone acetate (HY-B0469) .

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6

XL177A

6 Cited Publications

Cat. No.: HY-138794

CAS No.: 2417089-74-6

Purity: 99.60%

Target:

Deubiquitinase Histone Demethylase SARS-CoV

Research Areas:

Cancer

XL177A is a covalent USP7 inhibitor that blocks the deubiquitinase activity of USP7. XL177A destabilizes non-canonical PRC1 complexes or KDM6A and reduces chromatin deposition of H2AK119Ub, thereby relieving the repression of neuronal differentiation programs. Meanwhile, XL177A also regulates the ELOF1-UVSSA-USP7-nuclear β-catenin axis, decreasing the transcription levels of related proteins and the accumulation of nuclear β-catenin. XL177A exerts antiviral effects by reducing the expression levels of coronavirus receptors, and exhibits inhibitory activity against APC-mutated colorectal cancer cells, neuroblastoma, and coronaviruses including SARS-CoV-2 variants. XL177A is mainly used in studies related to colorectal cancer, neuroblastoma, and coronavirus infections .

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5

Pyridoxal 5'-phosphate monohydrate

5 Cited Publications

Cat. No.: HY-W011727A

CAS No.: 41468-25-1

Synonyms: Pyridoxal phosphate monohydrate

Category:

Ketones, Aldehydes, Acids Endogenous metabolite

Target:

Endogenous Metabolite Amyloid-β ERK

Pyridoxal 5'-phosphate monohydrate, the active form of vitamin B6, is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyzes the final stage in the production of the neurotransmitters dopamine and serotonin. Pyridoxal 5'-phosphate monohydrate is the most important coenzyme variant in the process of vitamin B6 intracellular phosphorylation and is interconvertible with other variants, including pyridoxine 5′‐phosphate (PNP) and pyridoxamine 5′‐phosphate (PMP) .

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5

Ailanthone

5 Cited Publications

Cat. No.: HY-N1943

CAS No.: 981-15-7

Synonyms: Δ13-Dehydrochaparrinone

Category:

Simaroubaceae Extract 500 - Internal Server Error | MedChemExpress

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