202

202 Publications Verification

Target:

MMP Parasite Bacterial Antibiotic Apoptosis Akt PI3K

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Doxycycline monohydrate is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline monohydrate is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline monohydrate also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline monohydrate induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline monohydrate also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline monohydrate has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers .

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187

Dasatinib monohydrate

187 Cited Publications

Cat. No.: HY-10181B

CAS No.: 863127-77-9

Purity: 99.58%

Synonyms: BMS-354825 Monohydrate

Target:

Bcr-Abl Src Autophagy Apoptosis

Research Areas:

Cancer

Dasatinib (BMS-354825) monohydrate is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The K_is are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib monohydrate inhibits Bcr-Abl and Src with IC₅₀s of <1.0 nM and 0.5 nM, respectively . Dasatinib monohydrate also induces apoptosis and autophagy.

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111

Tacrolimus monohydrate

111 Cited Publications

Cat. No.: HY-13756A

CAS No.: 109581-93-3

Purity: 99.67%

Synonyms: FK506 Monohydrate; Fujimycin Monohydrate; FR900506 Monohydrate

Category:

Infection Microorganisms Macrolide Antibiotics Anti-inflammation/Immunoregulatory Antibiotics Disease Research Disease Research Fields Inflammation/Immunology

Target:

Phosphatase FKBP Molecular Glues Bacterial Autophagy Antibiotic

Tacrolimus (FK506) monohydrate, a molecular glue, a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus monohydrate inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .

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103

Lapatinib ditosylate monohydrate

103 Cited Publications

Cat. No.: HY-50898B

CAS No.: 388082-78-8

Synonyms: GW572016 ditosylate Monohydrate; GW2016 ditosylate Monohydrate

Target:

EGFR Autophagy Ferroptosis

Research Areas:

Infection Metabolic Disease Cancer

Lapatinib ditosylate monohydrate (GW572016 ditosylate monohydrate) is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively .

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100

Regorafenib monohydrate

100 Cited Publications

Cat. No.: HY-10331A

CAS No.: 1019206-88-2

Purity: 99.96%

Synonyms: BAY 73-4506 Monohydrate

Target:

VEGFR Autophagy PDGFR Raf RET FGFR c-Kit Tie

Research Areas:

Cancer

Regorafenib (BAY 73-4506) monohydrate is an orally active and potent multi-targeted receptor tyrosine kinase inhibitor, with IC₅₀ values of 13/4.2/46, 22, 7, 1.5 and 2.5 nM for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1, respectively. Regorafenib monohydrate shows very robust antitumor and antiangiogenic activity .

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99

Luteolin monohydrate

99 Cited Publications

Cat. No.: HY-W303895

CAS No.: 6113-16-2

Target:

Keap1-Nrf2 Apoptosis Autophagy Endogenous Metabolite

Research Areas:

Others Cancer

Luteolin (monohydrate) is the monohydrate of Luteolin. Luteolin (Luteoline), a flavonoid, is also a potent Nrf2 inhibitor. Luteolin has anti-inflammatory and anticancer properties, induces apoptosis and cell cycle arrest in multiple human cancer cell lines, including non-small lung cancer cells, and inhibits cell metastasis and angiogenesis .

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86

Cyclophosphamide hydrate

86 Cited Publications

Cat. No.: HY-17420A

CAS No.: 6055-19-2

Synonyms: Cyclophosphamide Monohydrate

Target:

DNA Alkylator/Crosslinker

Research Areas:

Cancer

Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.

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80

Norepinephrine bitartrate monohydrate

80 Cited Publications

Cat. No.: HY-13715B

CAS No.: 108341-18-0

Purity: 99.96%

Synonyms: Levarterenol bitartrate Monohydrate; L-Noradrenaline bitartrate Monohydrate

Category:

Phenols Endogenous metabolite Disease Research Fields Endocrinology

Target:

Adrenergic Receptor Autophagy Endogenous Metabolite

Norepinephrine (Levarterenol; L-Noradrenaline) bitartrate monohydrate is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α₁, α₂, β₁ receptors .

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60

Ciprofloxacin hydrochloride monohydrate

60 Cited Publications

Cat. No.: HY-B0356B

CAS No.: 86393-32-0

Synonyms: Bay-09867 hydrochloride Monohydrate

Target:

Antibiotic Apoptosis Bacterial Reactive Oxygen Species (ROS) Topoisomerase Mitochondrial Metabolism Akt β-catenin

Research Areas:

Infection Cancer

Ciprofloxacin (Bay-09867) hydrochloride monohydrate is an orally active, blood-brain barrier permeable fluoroquinolone antibacterial agent. Ciprofloxacin hydrochloride monohydrate exerts bactericidal effects primarily by inhibiting topoisomerase II and IV. Ciprofloxacin hydrochloride monohydrate inhibits the proliferation of human dental pulp stem cells and chondrocytes from young rats, and also activates the Akt signaling pathway and upregulates markers such as β-catenin and Nanog to maintain the morphological characteristics of stem cells. Ciprofloxacin hydrochloride monohydrate induces significant neurotoxicity and tissue damage, including reducing serotonin and glutathione levels in the brain, inducing oxidative stress and depression-like behaviors, and causing articular cartilage damage. Ciprofloxacin hydrochloride monohydrate can be applied to research related to infections of necrotic young permanent teeth and neurotoxicity .

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56

Calcipotriol monohydrate

56 Cited Publications

Cat. No.: HY-10001A

CAS No.: 147657-22-5

Purity: 99.95%

Target:

VD/VDR

Research Areas:

Inflammation/Immunology Cancer

Calcipotriol monohydrate is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor.

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54

Nilotinib monohydrochloride monohydrate

54 Cited Publications

Cat. No.: HY-10159A

CAS No.: 923288-90-8

Purity: 99.91%

Synonyms: AMN107 monohydrochloride Monohydrate

Target:

Bcr-Abl Autophagy

Research Areas:

Cancer

Nilotinib monohydrochloride monohydrate is a second generation tyrosine kinase inhibitor (TKI), is significantly potent against BCR-ABL, and is active against many BCR-ABL mutants.

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40

Imipenem monohydrate

40 Cited Publications

Cat. No.: HY-B1369

CAS No.: 74431-23-5

Synonyms: N-Formimidoyl thienamycin Monohydrate; MK0787 Monohydrate

Category:

Infection Microorganisms Antibiotics Disease Research Antibacterial Disease Research Fields Other Antibiotics

Target:

Antibiotic Bacterial

Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections .

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35

Sitagliptin phosphate monohydrate

35 Cited Publications

Cat. No.: HY-13749B

CAS No.: 654671-77-9

Purity: 99.83%

Synonyms: MK-0431 phosphate Monohydrate

Target:

GLP Receptor Dipeptidyl Peptidase PKA ERK

Research Areas:

Infection Metabolic Disease Inflammation/Immunology Cancer

Sitagliptin (MK-0431) phosphate monohydrate is an orally active and highly selective DPP4 inhibitor with an IC₅₀ value of 19 nM. Sitagliptin phosphate monohydrate blocks the degradation of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) by competing inhibition mechanism (Kᵢ = 1 nM), thereby increasing the level of active incretin. Sitagliptin phosphate monohydrate can also directly stimulate the secretion of GLP-1 by intestinal L cells by activating the cAMP/PKA and ERK1/2 pathways, and this effect is independent of DPP-4. Sitagliptin phosphate monohydrate shows protective effects on pancreatic islet grafts in 1-type diabetes models. Sitagliptin phosphate monohydrate can be used for the study of 1-type and 2-type diabetes .

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29

Atropine sulfate monohydrate

29 Cited Publications

Cat. No.: HY-B0394

CAS No.: 5908-99-6

Synonyms: Tropine tropate sulfate Monohydrate; DL-Hyoscyamine sulfate Monohydrate

Target:

mAChR

Research Areas:

Cardiovascular Disease Neurological Disease Cancer

Atropine (Tropine tropate) sulfate monohydrate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀ values of 0.39 and 0.71 nM for Human mAChR M₄ and Chicken mAChR M₄, respectively. Atropine sulfate monohydrate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate monohydrate can be used for research of anti-myopia and bradycardia .

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27

Zoledronic acid monohydrate

27 Cited Publications

Cat. No.: HY-13777A

CAS No.: 165800-06-6

Purity: 99.88%

Synonyms: Zoledronate Monohydrate; CGP 42446 Monohydrate; CGP42446A Monohydrate; ZOL 446 Monohydrate

Target:

Apoptosis Autophagy Bacterial

Research Areas:

Metabolic Disease Cancer

Zoledronic acid monohydrate (Zoledronate monohydrate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic acid monohydrate inhibits the differentiation and apoptosis of osteoclasts. Zoledronic acid monohydrate also has anti-cancer effects .

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25

Quinidine hydrochloride monohydrate

25 Cited Publications

Cat. No.: HY-B1302

CAS No.: 6151-40-2

Category:

Cardiovascular Disease Natural Products 500 - Internal Server Error | MedChemExpress

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