415

Dexamethasone

415 Publications Verification

Cat. No.: HY-14648

CAS No.: 50-02-2

Purity: 99.86%

Synonyms: Hexadecadrol; Prednisolone F

Target:

Exosomes Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic ADC Payloads

Research Areas:

Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist, apoptosis inducer, and common disease inducer in experimental animals, constructing models of muscle atrophy, hypertension, and depression. Dexamethasone can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes. Dexamethasone also has potential for use in COVID-19 research .

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415

Dexamethasone (Water Soluble)

415 Publications Verification

Cat. No.: HY-14648C

CAS No.: 50-02-2

Purity: ≥98.0%

Synonyms: Dexamethasone cyclodextrin complex

Target:

Exosomes Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic

Research Areas:

Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Dexamethasone (Hexadecadrol) Water Soluble is a water-soluble form of Dexamethasone (HY-14648). Dexamethasone is a glucocorticoid receptor agonist, apoptosis inducer, and a common disease inducer in experimental animals. It can be used to construct models of muscle atrophy, hypertension, and depression. Dexamethasone can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes. Dexamethasone also has the potential to be used in COVID-19 research .(Sale size is the weight of dexamethasone)

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38

C188-9

38 Cited Publications

Cat. No.: HY-112288

CAS No.: 432001-19-9

Purity: 99.90%

Synonyms: TTI-101

Target:

STAT Apoptosis DNA Methyltransferase

Research Areas:

Metabolic Disease Inflammation/Immunology Cancer

C188-9 (TTI-101) is a STAT3 inhibitor with a K_d value of 4.7 nM. C188-9 targets the SH2 domain of STAT3, blocks the processes of STAT3 ligand binding, receptor recruitment, homodimerization and phosphorylation, and regulates STAT3-mediated genes associated with tumorigenesis and radioresistance. C188-9 regulates STAT1-mediated genes related to radioresistance and reduces the activation level of STAT1. C188-9 downregulates the expression of DNMT1, enhances DAC-induced demethylation and re-expression of RASSF1A, and simultaneously potentiates the anti-tumor effect of DAC on pancreatic cancer cells. C188-9 inhibits both anchorage-dependent and anchorage-independent growth of cancer cells, induces Apoptosis, blocks the growth of tumor xenografts, and suppresses muscle atrophy. C188-9 maintains muscle mass, increases body weight and improves grip strength in tumor-bearing mice. C188-9 can be used in research related to head and neck squamous cell carcinoma, pancreatic cancer, sepsis-related skeletal muscle wasting, non-small cell lung cancer, acute myeloid leukemia and cancer cachexia .

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13

Rebastinib

13 Cited Publications

Cat. No.: HY-13024

CAS No.: 1020172-07-9

Purity: 99.91%

Synonyms: DCC-2036

Target:

Bcr-Abl Cytochrome P450 Tie FOXO Src FLT3 Apoptosis

Rebastinib (DCC-2036) is an orally active, non-ATP-competitive Bcr-Abl inhibitor, with IC₅₀ values of 0.8 nM and 4 nM against Abl1 ^WT and Abl1 ^T315I, respectively. Rebastinib potently inhibits CYP2C8 (IC₅₀ = 0.0533 μM) and CYP2C9 (IC₅₀ = 2.54 μM). Rebastinib allosterically inhibits Tie2 with an IC₅₀ of 0.63 nM. Rebastinib inhibits the transcriptional activity of FoxO1. Rebastinib inhibits SRC family kinases, KDR and FLT3 kinases. Rebastinib induces Apoptosis. Rebastinib exerts anti-tumor activity in breast cancer. Rebastinib exerts anti-angiogenic effects. Rebastinib increases myotube diameter and improves reduced contractility. Rebastinib can be used in research related to triple-negative breast cancer, luminal breast cancer, pancreatic neuroendocrine tumors, muscle atrophy, cancer cachexia, chronic myeloid leukemia, and B-lymphocytic leukemia .

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7

GLPG0492

7 Cited Publications

Cat. No.: HY-18102

CAS No.: 1215085-92-9

Target:

Androgen Receptor

Research Areas:

Neurological Disease

GLPG0492 is an orally active, non-steroidal selective androgen receptor modulator. GLPG0492 exerts functional transactivation by binding to the ligand-binding domain of the receptor, exhibiting preferential partial agonist activity in muscle and bone tissues with low activity in reproductive tissues. GLPG0492 effectively counteracts muscle atrophy-related pathways, significantly enhances muscle strength, maintains motor ability, reduces fibrosis and improves electrophysiological parameters. GLPG0492 prevents immobilization-induced muscle atrophy and regulates muscle mass homeostasis, serving as a valuable tool compound for studies on Duchenne muscular dystrophy, muscle loss and various types of disuse musculoskeletal atrophy .

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2

Sabinene

2 Cited Publications

Cat. No.: HY-108943

CAS No.: 3387-41-5

Purity: 79.94%

Category:

Other Monoterpenes Terpenoids Other Diseases Plants Other Families Extract Disease Research Fields

Target:

Others

Sabinene is an naturally occurring bicyclic monoterpene which can be used as flavorings, perfume additives, fine chemicals, and advanced biofuels. Sabinene is also an orally active compound to attenuates skeletal muscle atrophy and regulates ROS-mediated MAPK/MuRF-1 pathways .

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1

Trevogrumab

1 Cited Publications

Cat. No.: HY-P99388

CAS No.: 1429201-24-0

Synonyms: REGN1033; SAR391786

Target:

TGF-beta/Smad

Research Areas:

Inflammation/Immunology

Trevogrumab (REGN-1033) is a monoclonal antibody targeting GDF8 (growth differentiation factor 8, also known as myostatin). Trevogrumab is used in research on muscle wasting conditions, including disuse atrophy, chronic diseases, and changes in food and nutrient intake .

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