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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
Mutagen
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "Mutagen" in MCE Product Catalog:
24
Research Areas:
N-Nitroso-N-methylurea (NMU;MNU;NMH) is a potent carcinogen, mutagen and teratogenand. N-Nitroso-N-methylurea is a direct-acting alkylating agent that interacts with DNA. N-Nitroso-N-methylurea targets multiple animal organs to cause various cancer and/or degenerative disease. N-Nitroso-N-methylurea is also a precursor in the synthesis of diazomethane .
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Methylnitronitrosoguanidine (MNNG) is an orally active alkylating agent with toxic and mutagenic effects. Methylnitronitrosoguanidine can as a carcinogen and mutagen . 50% water content, specifications are based on dry weight.
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4 Cited Publications
Cat. No.: HY-W011950
CAS No.: 52417-22-8
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Acridin-9-amine (9-Aminoacridine) hydrochloride hydrate is a mutagen and DNA modifier. Acridin-9-amine hydrochloride hydrate induces mutagenic lesions during DNA replication .
Cat. No.: HY-W755252
CAS No.: 3817-11-6
Synonyms: BBN
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N-Butyl-N-(4-hydroxybutyl)nitrosamine is a potent mutagen that can cause high-level of mutagenesis specifically in the epithelial cells (urothelial) of the urinary bladder. N-Butyl-N-(4-hydroxybutyl)nitrosamine is used to induce bladder cancer in rodents .
Cat. No.: HY-W014118
CAS No.: 101-86-0
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Dihydralazine sulfate is an antihypertensive hydrazine derivative and also a low-potency genotoxic agent. Dihydralazine sulfate is a direct-acting mutagen with a mixed gene mutation mechanism, which induces DNA fragmentation in the lung, kidney and spleen of mice, and induces sister chromatid exchange in mouse bone marrow cells. Dihydralazine sulfate specifically kills DNA repair-deficient bacteria. Dihydralazine sulfate is a vasodilator and antihypertensive agent that reduces systemic vascular resistance, increases cardiac output and heart rate, thereby lowering blood pressure. Dihydralazine sulfate can be used in research related to hypertension and severe early-onset preeclampsia .
Cat. No.: HY-112817
CAS No.: 139307-94-1
Synonyms: 8-Oxo-Deoxyguanosine triphosphate
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8-Oxo-dGTP (8-Oxo-Deoxyguanosine triphosphate) is an oxidized guanine nucleotide formed by ROS-mediated oxidative modification of dGTP, and it also serves as a key substrate for 8-oxo-dGTP pyrophosphohydrolases (such as hMTH1 and E. coli MutT). 8-Oxo-dGTP acts as a DNA mutagen, inserts into nascent DNA and pairs with adenine and cytosine, inducing A:T to C:G transversion mutations. Furthermore, 8-Oxo-dGTP causes oxidative DNA base modification, strand breakage and S-phase arrest, and ultimately triggers AIF-mediated apoptosis and promotes spontaneous carcinogenesis in mth1-deficient mice. Accumulation of 8-Oxo-dGTP in cells induces genomic instability, but it exhibits a tumor-suppressive effect that reduces tumor incidence in mouse models instead. 8-Oxo-dGTP is widely used in studies related to spontaneous carcinogenesis, Parkinson's disease, Alzheimer's disease, heart failure and tumor mechanisms .
Cat. No.: HY-160596
CAS No.: 2409156-19-8
Synonyms: 5-Formyl-deoxycytidine lithium
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5-Formyl-dCTP (5-Formyl-deoxycytidine) lithium is a DCTPP1 substrate. 5-Formyl-dCTP lithium acts as a mutagen/epigenetic disruptor via DNA polymerase incorporation, mutagenic mispairings, and disturbed epigenetic programming. 5-Formyl-dCTP lithium can be used for research on genotoxicity .
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Cat. No.: HY-N3388
CAS No.: 66056-30-2
Category:
Leguminosae/Fabaceae Extract Plant Flavonoids Glycyrrhiza uralensis Fisch. Extract Metabolic Disease Phenols Polyphenols Disease Research Fields Isoflavones
Target:
against carcinogenic mutagen, by preventing DNA damage. Licoisoflavone B can be used for the research of psoriasis, Lassa fever, inflammation and cancer .
Cat. No.: HY-W127746
CAS No.: 550-74-3
Research Areas:
Picrolonic acid is a nematode hatching agent and bacterial frameshift mutagen. Picrolonic acid induces egg hatching in various nematodes. Picrolonic acid induces frameshift mutations in Salmonella. Picrolonic acid preferentially inhibits the growth of DNA polymerase-deficient E. coli . Picrolonic acid also serves as an analytical reagent for the determination of calcium, magnesium, lead, strontium, and thorium, and for the analysis of alkaloids, tryptophan, and phenylalanine. Picrolonic acid is used in research related to bacterial and parasitic infections .
Cat. No.: HY-109855
CAS No.: 100325-51-7
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CP-67015, a quinolone antibiotic, is a potent topoisomerase II inhibitor. CP-67015 is a positive direct-acting mutagen in mammalian cells with both gene and chromosomal level effects .
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Levofloxacin N-oxide is an oxidation product and impurity of Levofloxacin (HY-B0330), and it is a non-mutagen. Under specific concentration conditions with the addition of S-9 mixture, Levofloxacin N-oxide increases structural chromosomal aberrations in hamster lung cells .
Cat. No.: HY-W717139
CAS No.: 2733722-92-2
Cat. No.: HY-W014118R
CAS No.: 101-86-0
Cat. No.: HY-P86690
Synonyms: Cyclin; DNA polymerase delta auxiliary protein; HGCN8729; MGC8367; Mutagen-sensitive 209 protein; Pcna/cyclin; PCNAR; Polymerase delta accessory protein; Proliferating Cell Nuclear Antigen
Cat. No.: HY-W585908
CAS No.: 108354-47-8
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2-Amino-3-Methylimidazo[4,5-f]quinoxaline is a food mutagen with mutagenic activity.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
