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195 Results for "

Mutagenicity

" in MedChemExpress (MCE) Product Catalog:

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Pentagalloylglucose

18 Publications Verification

Cat. No.: HY-N0527

CAS No.: 14937-32-7

Synonyms: Penta-O-galloyl-β-D-glucose; 1,2,3,4,6-Pentagalloyl glucose

Category:

Infection Anti-aging Phenols Polyphenols Plants Other Families Extract Disease Research Fields

Target:

JAK Keap1-Nrf2 Apoptosis β-catenin Reactive Oxygen Species (ROS) E1/E2/E3 Enzyme

Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is an orally active gallic tannin compound and an inducer of apoptosis and autophagy. Pentagalloglucose induces cell apoptosis and autophagy through the GSK3β/β-catenin pathway. Pentagalloylglucose inhibits UBE2T-mediated p53 ubiquitination, upregulates p53, downregulates RRM1/RRM2 in pancreatic cancer organoids. Pentagalloglucose has antioxidant, anti mutagenic, anti-inflammatory, anticonvulsant, cardioprotective, anti allergic, cholesterol lowering, and anti-tumor activities .

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Tempo

16 Cited Publications

Cat. No.: HY-W001187

CAS No.: 2564-83-2

Target:

Mitochondrial Metabolism DNA/RNA Synthesis Reactive Oxygen Species (ROS)

Research Areas:

Cancer

Tempo is a nitric oxide radical and a selective scavenger of ROS in mitochondria. Tempo is also an organocatalyst that disproportionates superoxide and oxidizes primary alcohols to aldehydes in a catalytic cycle. Tempo has mutagenic and antioxidant effects and can induceDNA strand breaks. Tempo also exerts cytotoxic and mutagenic properties in mouse lymphoma cells .

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