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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
31 Results for "
Myocardium
" in MedChemExpress (MCE) Product Catalog:
Products (31)
31 Results for "Myocardium" in MCE Product Catalog:
266
266 Publications Verification
Synonyms: Angiotensin II; Ang II; DRVYIHPF
Target:
266
266 Publications Verification
Synonyms: Angiotensin II acetate; Ang II acetate; DRVYIHPF acetate
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Research Areas:
Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology Cancer
266
266 Publications Verification
Synonyms: Angiotensin II TFA; Ang II TFA; DRVYIHPF TFA
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Research Areas:
5
5 Cited Publications
Research Areas:
Infection Cardiovascular Disease Neurological Disease Cancer
EHNA hydrochloride is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2)(IC50=4 μM) and adenosine deaminase (ADA). EHNA hydrochloride exerts a concentration inhibition of the cGMP-stimulated PDE II (cGs-PDE)(IC50:0.8 μM (human), 2 μM (porcine myocardium)), but has smaller inhibitory effect on the unstimulated PDE2 activity. EHNA hydrochloride play roles in mediating diverse pharmacological responses, including antiviral, antitumour and antiarrhythmic effects .
1
1 Cited Publications
Cat. No.: HY-17436
CAS No.: 167221-71-8
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Clevidipine is a selective, short-acting L-type calcium channel antagonist with an IC50 of 7.1 nM. Clevidipine can competitively bind to calcium channels and exert rapid vasoselective vasodilation by blocking the influx of extracellular calcium ions, thereby reducing peripheral vascular resistance and effectively controlling acute severe hypertension. Clevidipine can also protect the myocardium from reperfusion injury by promoting the release of nitric oxide (NO). Clevidipine can be used in the research of acute hypertension, perioperative blood pressure management, and myocardial ischemia-reperfusion injury .
1
1 Cited Publications
Cat. No.: HY-E70005L
CAS No.: 9001-12-1
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Collagenase (Type B, animal free) is an animal-free collagen-degrading digestive enzyme and tissue dissociation reagent. Collagenase (Type B, animal free) can digest mouse aorta, myocardium, human umbilical cord, and human liver tissue to isolate primary leukocytes, adult mouse cardiomyocytes, human mesenchymal stem cells, and individual hepatocytes. Collagenase (Type B, animal free) can be used in studies related to liver cirrhosis .
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1 Cited Publications
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MMPSI is a potent and selective small molecule caspase 3 and caspase 7 inhibitor with an IC50 of 1.7 μM for human caspase-3. MMPSI can significantly reduce ischemia-reperfusion-induced infarct size in the isolated rabbit heart, and reduce apoptosis in both the ischemic myocardium and isolated cardiomyocytes. MMPSI can be used for researching cardioprotection .
Cat. No.: HY-P5217
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Cat. No.: HY-W704966
CAS No.: 4421-58-3
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2-Stearoyl-sn-glycero-3-PC is a lysophospholipid that contains stearic acid (HY-B2219) at the sn-2 position. It has been found in rabbit myocardium.
Cat. No.: HY-P5792
CAS No.: 102686-43-1
Synonyms: ANP (3-28) (human)
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Cat. No.: HY-W276164
CAS No.: 1120-04-3
Synonyms: Sodium stearyl sulfate
Cat. No.: HY-19463A
CAS No.: 470454-73-0
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F 15845 is a highly effective persistent sodium current blocker. F 15845 also is a cardioprotective agent, has anti-ischemic activity and exerts short- and long-term cardioprotection after myocardial infarction. F 15845 can be used for the research of myocardium functional impairment .
Cat. No.: HY-19463
CAS No.: 866760-23-8
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F 15845 hydrobromide is a highly effective persistent sodium current blocker. F 15845 hydrobromide is also a cardioprotective agent, has anti-ischemic activity and exerts short- and long-term cardioprotection after myocardial infarction. F 15845 hydrobromide can be used for the research of myocardium functional impairment .
Cat. No.: HY-N3931
CAS No.: 34274-91-4
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Cat. No.: HY-103160B
CAS No.: 51350-19-7
Research Areas:
Infection Cardiovascular Disease Neurological Disease Cancer
EHNA is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2)(IC50=4 μM) and adenosine deaminase (ADA). EHNA exerts a concentration inhibition of the cGMP-stimulated PDE II (cGs-PDE)(IC50:0.8 μM (human), 2 μM (porcine myocardium)), but has smaller inhibitory effect on the unstimulated PDE2 activity. EHNA play roles in mediating diverse pharmacological responses, including antiviral, antitumour and antiarrhythmic effects .
Cat. No.: HY-116119
CAS No.: 120838-62-2
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Research Areas:
BDF 9148 is a sodium-channel activator with antiarrhythmic properties that produces a significant CAMP-independent positive inotropic effect in left ventricular myocardium from failing hearts. BDF 9148 is promising for research of myocardial failure .
Cat. No.: HY-W184837
CAS No.: 113578-26-0
Synonyms: KR-1008
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m-Nisoldipine (KR-1008) is a dihydropyridine calcium antagonist that can significantly increase cardiac output and heart index, significantly reduce the negative inotropic effect on the myocardium, and has a relatively high selectivity for the thoracic aorta. m-Nisoldipine can be used in the research of cardiovascular diseases .
Cat. No.: HY-123721
CAS No.: 78816-67-8
Synonyms: AWD-19-166; GS 015
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Tiracizine hydrochloride (AWD-19-166) is a Class I antiarrhythmic drug with activity that reduces myocardial contractile function. Tiracizine hydrochloride was studied in patients with ischemic heart disease, showing its effects on the myocardium. Tiracizine hydrochloride reduces myocardial contractility and may have potential use in the management of heart disease .
Cat. No.: HY-14257
CAS No.: 166095-95-0
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BMS-191095 hydrochloride is a mitochondrial KATP channel opener. BMS-191095 hydrochloride can protect the myocardium without causing vasodilation or affecting electrophysiology, by prolonging the contraction time during ischemia, improving contractile function after reperfusion, and reducing lactate dehydrogenase (LDHM) release, thereby exerting its cardioprotective effects .
Cat. No.: HY-117135
CAS No.: 186086-10-2
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HNS-32 is a compound with antiarrhythmic and vasodilatory effects in canine hearts, showing superior protective effects against ischemic and reperfusion arrhythmias compared to an equivalent dose of Mexiletine hydrochloride (HY-A0093). Furthermore, HNS-32 exhibits significant negative chronotropic effects on mammalian ventricular myocardium, indicating its potential application value in the study of acute coronary syndrome .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
