123

EIPA hydrochloride

123 Publications Verification

Cat. No.: HY-101840A

CAS No.: 1345839-28-2

Purity: 98.31%

Synonyms: L593754 hydrochloride; MH 12-43 hydrochloride; Ethylisopropylamiloride hydrochloride

Target:

TRP Channel Autophagy COX Prostaglandin Receptor Na+/H+ Exchanger (NHE)

Research Areas:

Inflammation/Immunology Cancer

EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC₅₀ of 10.5 μM. EIPA hydrochloride also enhances autophagy by inhibiting Na ⁺/H ⁺-exchanger 3 (NHE3). EIPA hydrochloride inhibits macropinocytosis as well. EIPA hydrochloride can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma .

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123

EIPA

123 Publications Verification

Cat. No.: HY-101840

CAS No.: 1154-25-2

Purity: 99.73%

Synonyms: L593754; MH 12-43; Ethylisopropylamiloride

Target:

TRP Channel Prostaglandin Receptor Autophagy COX Na+/H+ Exchanger (NHE)

Research Areas:

Inflammation/Immunology Cancer

EIPA (L593754) is an orally active TRPP3 channel inhibitor with an IC₅₀ of 10.5 μM. EIPA also enhances autophagy by inhibiting Na ⁺/H ⁺-exchanger 3 (NHE3). EIPA inhibits macropinocytosis as well. EIPA can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma .

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84

Oleic acid sodium

84 Cited Publications

Cat. No.: HY-N1446B

CAS No.: 143-19-1

Synonyms: Sodium oleate; 9-cis-Octadecenoic acid sodium; 9Z-Octadecenoic acid sodium

Category:

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Environmental Pollutants Apoptosis Na+/K+ ATPase

Sodium oleate (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium . Sodium oleate is a Na ⁺/K ⁺ ATPase activator .

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84

Oleic acid

84 Cited Publications

Cat. No.: HY-N1446

CAS No.: 112-80-1

Synonyms: 9-cis-Octadecenoic acid; 9Z-Octadecenoic acid

Category:

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Cancer

Target:

Endogenous Metabolite Apoptosis Na+/K+ ATPase

Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid . Oleic acid is a Na ⁺/K ⁺ ATPase activator .

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53

Sodium carboxymethyl cellulose (Viscosity:800-1200 mPa.s)

53 Cited Publications

Cat. No.: HY-Y0703

CAS No.: 9004-32-4

Synonyms: CMC-NA (Viscosity:800-1200 mPa.s)

Sodium carboxymethyl cellulose (Viscosity:800-1200 mPa.s) is the sodium salt of cellulose arboxymethyl and frequently used as viscous agent, paste and barrier agent.

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45

Monensin sodium

45 Cited Publications

Cat. No.: HY-N0150

CAS No.: 22373-78-0

Synonyms: Monensin A sodium

Category:

Microorganisms Antibiotics Disease Research Antibacterial Disease Research Fields Other Antibiotics Cancer Plant agriculture research

Target:

Exosomes Bacterial Antibiotic Na+/H+ Exchanger (NHE) Parasite Apoptosis Fungal Wnt

Monensin (Monensin A) sodium, an orally active antibiotic, is an ionophore that mediates Na ⁺/H ⁺ exchange. Monensin sodium is a potent Wnt signaling inhibitor. Monensin sodium causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin sodium can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects .

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45

Monensin

45 Cited Publications

Cat. No.: HY-N4302

CAS No.: 17090-79-8

Synonyms: Monensin A

Category:

Infection Natural Products Microorganisms Disease Research Fields

Target:

Exosomes Bacterial Apoptosis Antibiotic Parasite Na+/H+ Exchanger (NHE) Fungal Wnt

Monensin (Monensin A), an orally active antibiotic, is an ionophore that mediates Na ⁺/H ⁺ exchange. Monensin is a potent Wnt signaling inhibitor. Monensin causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects .

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36

Sivelestat sodium

36 Cited Publications

Cat. No.: HY-17443A

CAS No.: 150374-95-1

Synonyms: ONO5046-NA; Sodium sivelestat; EI546 sodium; LY544349 sodium

Target:

Elastase SARS-CoV

Research Areas:

Cancer

Sivelestat (EI546) sodium is a competitive inhibitor of human neutrophil elastase, with an IC₅₀ of 44 nM and a K_i of 200 nM. Sivelestat (EI546) sodium has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19 .

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34

Sodium dichloroacetate

34 Cited Publications

Cat. No.: HY-Y0445A

CAS No.: 2156-56-1

Target:

PDK-1 NKCC PDHK Reactive Oxygen Species (ROS) Apoptosis

Research Areas:

Cancer

Sodium dichloroacetate is an orally active pyruvate dehydrogenase kinase (PDK) inhibitor. Sodium dichloroacetate also stimulates pyruvate dehydrogenase (PDH) activity and works as a Na ⁺-K ⁺-2Cl ⁻ cotransporter (NKCC) inhibitor. Sodium dichloroacetate prevents the phosphorylation of the E1α subunit of PDC, promoting the entry of pyruvate into the mitochondria for oxidative metabolism, reducing lactate production, and simultaneously increasing the production of reactive oxygen species (ROS). Sodium dichloroacetate inhibits tumor cell proliferation and induces apoptosis. Sodium dichloroacetate is promising for research of cancers .

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23

DiSC3(5)

23 Cited Publications

Cat. No.: HY-D0085

CAS No.: 53213-94-8

DiSC3(5) is a fluorescent probe commonly used as a tracer dye to evaluate mitochondrial membrane potential. The excitation/emission wavelength of DiSC3(5) is up to 622/670 nm. DiSC3(5) can inhibit the respiratory system associated with mitochondrial NAD, and the IC₅₀ value is 8 μM. DiSC3(5) in the presence of Na ⁺/K ⁺-ATPase inhibitor ouabain 2 can induce membrane hyperpolarization of Ehrlich ascites tumor cells .

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20

SEA0400

20 Cited Publications

Cat. No.: HY-15515

CAS No.: 223104-29-8

Purity: 99.95%

Target:

Na+/Ca2+ Exchanger

Research Areas:

Cardiovascular Disease

SEA0400 is a novel and selective inhibitor of the Na ⁺-Ca ²⁺ exchanger (NCX), inhibiting Na ⁺-dependent Ca ²⁺ uptake in cultured neurons, astrocytes, and microglia with IC₅₀s of from 5 to 33 nM.

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19

Bumetanide

19 Cited Publications

Cat. No.: HY-17468

CAS No.: 28395-03-1

Synonyms: Ro 10-6338; PF 1593

Target:

NKCC

Research Areas:

Cardiovascular Disease Metabolic Disease

Bumetanide (Ro 10-6338; PF 1593), a highly potent loop diuretic, is a Na ⁺-K ⁺-Cl ⁺ cotransporter (NKCC) blocker. Bumetanide is a selective NKCC1 inhibitor, but also inhibits NKCC2, with IC₅₀s of 0.68 μM and 4.0 μM for hNKCC1A and hNKCC2A, respectively .

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