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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
73 Results for "
NAT
" in MedChemExpress (MCE) Product Catalog:
Products (73)
73 Results for "NAT" in MCE Product Catalog:
4
4 Cited Publications
NAT is an initial hit of NAMPT activator with an EC50 of 5.7 μM and a KD of 379 nM. NAMPT is the rate-limiting enzyme in the NAD salvage pathway, which makes it an attractive target for the research of many diseases associated with NAD exhaustion such as neurodegenerative diseases .
78
78 Publications Verification
Synonyms: Paracetamol; 4-Acetamidophenol; 4'-Hydroxyacetanilide
26
26 Cited Publications
Cat. No.: HY-16706A
CAS No.: 1622921-15-6
Target:
Research Areas:
Remodelin hydrobromide is an orally active and selective inhibitor of acetyltransferase NAT10. Remodelin hydrobromide inhibits NAT10 activitity and slows DNA replication and suppresses growth of prostate cancer cells. Remodelin hydrobromide inhibits the growth of prostate cancer and hepatocellular carcinoma in xenograft model. Remodelin hydrobromide enhances the healthspan in hutchinson-gilford progeria syndrome (HGPS) mouse model .
26
26 Cited Publications
Cat. No.: HY-16706
CAS No.: 949912-58-7
Target:
Research Areas:
Remodelin is an orally active and selective inhibitor of acetyltransferase NAT10. Remodelin inhibits NAT10 activitity and slows DNA replication and suppresses growth of prostate cancer cells. Remodelin inhibits the growth of prostate cancer and hepatocellular carcinoma in xenograft model. Remodelin enhances the healthspan in hutchinson-gilford progeria syndrome (HGPS) mouse model .
1
1 Cited Publications
Synonyms: Paracetamol (Standard); 4-Acetamidophenol (Standard); 4'-Hydroxyacetanilide (Standard)
Research Areas:
Acetaminophen (Standard) is the analytical standard of Acetaminophen. This product is intended for research and analytical applications. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .
1
Target:
1
1 Cited Publications
Cat. No.: HY-P70411
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HYAL1; Hyaluronoglucosaminidase-1; Hyaluronidase 1; Tumor Suppressor LUCA-1; LUCA1; Plasma Hyaluronidase; HYAL-1; Hyaluronidase; Hyaluronoglucosaminidase 1; Hyal-1; Lung Carcinoma Protein 1; MPS9; Hyaluronidase-1; NAT6; LuCa-1
Species:
Human
Source:
HEK293
Cat. No.: HY-66005S
CAS No.: 64315-36-2
Synonyms: Paracetamol-d4; 4-Acetamidophenol-d4; 4'-Hydroxyacetanilide-d4
Target:
Research Areas:
NAMPT activator-3, a NAT derivative, is a NAMPT activator with an EC50 of 2.6 μM and a KD of 132 nM. NAMPT activator-3 effectively protects cultured cells from FK866 (HY-50876)-mediated toxicity. NAMPT activator-3 exhibits strong neuroprotective efficacy in a chemotherapy-induced peripheral neuropathy (CIPN) mouse model without any overt toxicity .
Cat. No.: HY-145476
CAS No.: 887407-16-1
Synonyms: N-NAT; N'-NitrosoaNATabine
N-Nitrosoanatabine (N-NAT; N'-Nitrosoanatabine) is a tobacco-specific nitrosamine that exists in tobacco, tobacco products and e-cigarettes .
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Research Areas:
4-Acetamidophenyl acetate is an impurity of Acetaminophen (HY-66005). 4-Acetamidophenyl acetate acts as an intermediate in the synthesis of Acetaminophen. Acetaminophen is a selective COX-2 inhibitor (IC50=25.8 μM), and is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .
Cat. No.: HY-66005S1
CAS No.: 60902-28-5
Synonyms: Paracetamol-d3; 4-Acetamidophenol-d3; 4'-Hydroxyacetanilide-d3
Cat. No.: HY-161875
Target:
Research Areas:
NAT1-IN-1 (compound 350) is a potent N-acetyltransferase 1 (NAT1)-targeted inhibitor, with an IC50 of 44 nM. NAT1-IN-1 can be used for the research of hypermetabolic diseases such as amyotrophic lateral sclerosis, cancer cachexia, and sepsis .
Cat. No.: HY-178360
CAS No.: 2966791-41-1
Research Areas:
NP1192 is a potent, selective PROTAC NAT10 degrader. NP1192 promotes NAT10 ubiquitination and degradation. NP1192 inhibits ac4C modification. NP1192 demonstrates dual inhibition of hypoxia-driven glycolysis and immunosuppression via NAT10/HIF-1α/PD-L1 axis disruption, achieving superior antitumor efficacy and synergizing with anti-PD-L1 both in vitro and in vivo. NP1192 can be used for ovarian, cervical, and glioblastoma cancer research .
Target:
Research Areas:
Acetylisoniazid is a primary Isoniazid (HY-B0329) metabolite mediated by N-acetyltransferase (NAT). Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity .
Cat. No.: HY-66005S2
CAS No.: 1219798-53-4
Synonyms: Paracetamol-d7; 4-Acetamidophenol-d7; 4'-Hydroxyacetanilide-d7
Synonyms: APA
Target:
Research Areas:
NAT2-IN-1 (APA) is an inhibitor of agent metabolic enzyme N-acetyltransferase 2 (NAT2). NAT2-IN-1 can selectively kill slow NAT2 cells .
Cat. No.: HY-66005S4
CAS No.: 360769-21-7
Synonyms: Paracetamol-13C2,15N; 4-Acetamidophenol-13C2,15N; 4'-Hydroxyacetanilide-13C2,15N
Cat. No.: HY-106739
CAS No.: 90697-57-7
Synonyms: NAT 05-239
Target:
Research Areas:
Motapizone (NAT 05-239) is a selective PDE3 inhibitor. Motapizone moderately inhibits cytokine release in lipopolysaccharide (LPS)-induced alveolar macrophages. Motapizone also inhibits human platelet aggregation by increasing intracellular cAMP .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
