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16 Results for "

NB cell

" in MedChemExpress (MCE) Product Catalog:

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NSC697923

8 Cited Publications

Cat. No.: HY-13811

CAS No.: 343351-67-7

Purity: 99.93%

Target:

E1/E2/E3 Enzyme Apoptosis

Research Areas:

Cancer

NSC697923 is a potent UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13) inhibitor. NSC697923 induces neuroblastoma (NB) cell death via promoting nuclear importation of p53 in p53 wild-type NB cells. NSC697923 also induces cell death in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway. NSC697923 inhibits DNA damage and NF-κB signaling. Antitumor activity .

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A 71915

Cat. No.: HY-P2026

CAS No.: 132956-87-7

Target:

Natriuretic Peptide Receptor (NPR)

Research Areas:

Cardiovascular Disease

A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist (pK_i= 9.18). A 71915 displaces [ ¹²⁵I]ANP dose dependently, with a K_i of 0.65 nM. A71915( pA₂= 9.48) against rat ANP-induced cGMP production in NB-OK-1 cells .

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Spicamycin

Cat. No.: HY-127130

CAS No.: 87099-85-2

Target:

Bcl-2 Family Apoptosis Fungal Antibiotic

Research Areas:

Infection Cancer

Spicamycin, an adenine nucleoside antibiotic with antifungal and antitumor activities. Spicamycin is also a potent inducer of differentiation of myeloid leukemia cells. Spicamycin induces apoptosis in NB4 cells via down-regulation of Bcl-2 expression and modulation of PML protein .

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Thymectacin

Cat. No.: HY-106168

CAS No.: 232925-18-7

Purity: 98.21%

Synonyms: NB1011

Target:

Thymidylate Synthase

Research Areas:

Cancer

Thymectacin (NB1011) is an agent selectively targeting tumor cells that have a high expression of thymidylate synthase (TS). Thymectacin is an aryloxy phosphoramidate derivative of BVdU (brivudin) .

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