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71 Results for "

NF-AT

" in MedChemExpress (MCE) Product Catalog:

Products (71)

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223

Cyclosporin A

223 Publications Verification

Cat. No.: HY-B0579

CAS No.: 59865-13-3

Synonyms: Cyclosporine A; Ciclosporin A; CsA

Category:

Natural Products Microorganisms Anti-aging Disease Research Fields Inflammation/Immunology Cancer

Target:

Molecular Glues Complement System Antibiotic Cyclophilin

Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM . Cyclosporin A is a molecular glue, binds to cyclophilin and calcineurin, leading to inactivation of nuclear Factor of activated T Cells (NFAT) and a subsequent decrease in the immune response. Cyclosporin A also inhibits CD11a/CD18 adhesion .

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NFAT Inhibitor-1

18 Cited Publications

Cat. No.: HY-P1026

CAS No.: 249537-73-3

Synonyms: VIVIT peptide

Target:

Nuclear Factor of activated T Cells (NFAT)

Research Areas:

Inflammation/Immunology

NFAT Inhibitor (VIVIT peptide) is an inhibitor of nuclear factor of activated Tcells (NFAT) that selectively inhibits calcineurin-mediated dephosphorylation of NFAT .

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11R-VIVIT

9 Cited Publications

Cat. No.: HY-P1430

CAS No.: 592517-80-1

Synonyms: Cell permeable NFAT inhibitor

Target:

Nuclear Factor of activated T Cells (NFAT)

Research Areas:

Metabolic Disease

11R-VIVIT is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. 11R-VIVIT can be used for the research of podocyte and diabetic nephropathy .

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11R-VIVIT TFA

9 Cited Publications

Cat. No.: HY-P1430A

Synonyms: Cell permeable NFAT inhibitor TFA

Target:

Nuclear Factor of activated T Cells (NFAT)

Research Areas:

Metabolic Disease

11R-VIVIT TFA is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. 11R-VIVIT TFA can be used for the research of podocyte and diabetic nephropathy .

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INCA-6

5 Cited Publications

Cat. No.: HY-108544

CAS No.: 3519-82-2

Purity: 98.85%

Synonyms: Triptycene-1,4-quinone

Target:

Nuclear Factor of activated T Cells (NFAT)

Research Areas:

Cardiovascular Disease

INCA-6 (Triptycene-1,4-quinone) is a cell-permeable NFAT inhibitor. INCA-6 specifically blocks targeting of NFAT(P) substrate to the calcineurin (CN) phosphatase site and is an effective inhibitor of CN-NFAT signaling .

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Tropisetron

5 Cited Publications

Cat. No.: HY-B0072

CAS No.: 89565-68-4

Synonyms: SDZ-ICS-930 free base

Target:

5-HT Receptor nAChR p38 MAPK NF-κB AP-1 Nuclear Factor of activated T Cells (NFAT) JAK

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

Tropisetron is an orally active 5-HT3R antagonist (K_i = 5.3 nM) as well as being a potent and selective α7 nicotinic partial agonist (EC₅₀ = 1.3 μM). Tropisetron prevents phosphorylation and activation of the p38 MAPK. Tropisetron inhibits both IL-2 gene transcription and IL-2 synthesis in stimulated T cells. Tropisetron inhibits the binding to DNA and the transcriptional activity of NFAT and AP-1. Tropisetron is anti-inflammatory and antiemetic. Tropisetron has antitumor and neuroprotective effects. Tropisetron can be studied in research for diseases including hemorrhagic cystitis, chronic joint inflammation, lung cancer and chronic cerebral hypoperfusion .

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