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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
204 Results for "
NFkB P65
" in MedChemExpress (MCE) Product Catalog:
Products (204)
204 Results for "NFkB P65" in MCE Product Catalog:
165
165 Publications Verification
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JSH-23 is an NF-κB inhibitor which inhibits NF-κB transcriptional activity with an IC50 of 7.1 μM in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. JSH-23 inhibits nuclear translocation of NF-κB p65 without affecting IκBα degradation .
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38 Cited Publications
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SC75741 is a broad and efficient NF-κB inhibitor with an IC50 of 200 nM for p65 . SC75741 blocks influenza viruses (IV) replication. SC75741 impairs DNA binding of the NF-κB subunit p65, resulting in reduced expression of cytokines, chemokines, and pro-apoptotic factors. SC75741 subsequently inhibits caspase activation and blocks caspase-mediated nuclear export of viral ribonucleoproteins .
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Category:
Infection Acanthaceae Extract Plant Terpenoids Diterpenoids Disease Research Fields Inflammation/Immunology Andrographis paniculata (Burm. F.) Nees Extract
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27 Cited Publications
Synonyms: β-Sitosterol (purity>98%); 22,23-Dihydrostigmasterol (purity>98%)
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17 Cited Publications
Synonyms: (-)-Epicatechol; Epicatechin; epi-Catechin
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Anti-aging Endogenous metabolite Theaceae Extract Plant Flavonoids Sunscreen Flavanols Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Extract Cosmetic Research Disease Research Fields Inflammation/Immunology Cancer
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17 Cited Publications
Synonyms: Crategolic acid; 2α-Hydroxyoleanolic acid
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Plant Xanthones Phenols Polyphenols Liliaceae Extract Anemarrhena asphodeloides Bunge Extract Disease Research Fields Cancer
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16 Cited Publications
Cat. No.: HY-16657
CAS No.: 163847-77-6
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TAPI-1 is a broad-spectrum MMP inhibitor and NF-κB p65 inhibitor that targets ADAM17/TACE, ADAM10 and other proteins. TAPI-1 reduces the proteolytic cleavage of membrane-bound TNF-α, decreases TNF-α levels, inhibits NF-κB pathway activation, and downregulates profibrotic markers. TAPI-1 reduces the proportion of proinflammatory immune cells, alleviates cardiac and airway fibrosis, and improves cardiac function after myocardial infarction. Meanwhile, TAPI-1 inhibits the viability, migration and invasion of esophageal squamous cell carcinoma cells, enhances the chemosensitivity of Cisplatin (HY-17394), induces apoptosis, and shows low toxicity to normal esophageal epithelial cells. TAPI-1 can be widely used in studies related to myocardial infarction-induced heart failure, severe traumatic tracheal stenosis, esophageal squamous cell carcinoma and other conditions .
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13 Cited Publications
Cat. No.: HY-N0373
CAS No.: 58749-23-8
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Flavones Metabolic Disease Brassicaceae Extract Coronopus didymus Extract Plant Flavonoids Phenols Polyphenols Phyllanthus Extract Disease Research Fields Euphorbiaceae Extract
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Plant Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Caprifoliaceae Extract Disease Research Fields Lonicera japonica Thunb. Extract Cancer
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Plant Terpenoids Sesquiterpenes Other Families Extract Disease Research Fields Inflammation/Immunology
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6 Cited Publications
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IAXO-102 is a TLR4 antagonist which negatively regulates TLR4 signalling. IAXO-102 inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdominal aortic aneurysm development .
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5 Cited Publications
Cat. No.: HY-N4187
CAS No.: 144506-15-0
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
