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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
32 Results for "
NIMA
" in MedChemExpress (MCE) Product Catalog:
Products (32)
32 Results for "NIMA" in MCE Product Catalog:
3
3 Cited Publications
ZINC05007751 is a potent NIMA-related kinase NEK6 inhibitor with an IC50 of 3.4 μM. ZINC05007751 shows antiproliferative activity against a panel of human cancer cell lines, and displays a synergistic effect with Cisplatin and Paclitaxel in a BRCA2 mutated ovarian cancer cell line. ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity was observed against NEK2, NEK7, and NEK9 .
1
1 Cited Publications
MBM-55 is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 1 nM. MBM-55 shows a 20-fold or greater selectivity in most kinases with the exception of RSK1 (IC50=5.4 nM) and DYRK1a (IC50=6.5 nM). MBM-55 effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-55 shows antitumor activities, and no obvious toxicity to mice .
1
1 Cited Publications
JH295 is a potent, irreversible and selective NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 770 nM. JH295 inhibits cellular Nek2 via alkylation of Cys22. JH295 is inactive against the mitotic kinases, Cdk1, Aurora B or Plk1, and does not perturb bipolar spindle assembly or the spindle assembly checkpoint . JH295 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
1
1 Cited Publications
PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor (API-1) with an IC50 of 72.3 nM. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase (PPIase) domain and potently inhibits Pin1 cis-trans isomerizing activity. PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development .
1
1 Cited Publications
Cat. No.: HY-P75935
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NEK7; Never In Mitosis A-Related Kinase 7; NIMA Related Kinase 7; NIMA-Related Protein Kinase 7; NIMA (Never In Mitosis Gene A)-Related Kinase 7; NEK6-Subfamily Protein Kinase; Serine/Threonine-Protein Kinase Nek7
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-172162
Target:
Research Areas:
LC-04-045 is a selective NIMA-related kinase 7 (NEK7) molecular glue degrader. LC-04-045 induces NEK7 degradation via the CRBN-based ubiquitin-proteasome system, dependent on the glycine 57-containing degron motif. LC-04-045 inhibits secretion of downstream cytokines IL-1β and IL-18. LC-04-045 can be used for the research of lymphoblastic leukemia .
Cat. No.: HY-101030A
CAS No.: 2083621-91-2
MBM-17S is a potent NIMA-related kinase 2 (Nek2) inhibitor, with an IC50 of 3 nM. MBM-17S effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-17S shows antitumor activities, and no obvious toxicity to mice .
Cat. No.: HY-169933
CAS No.: 2738569-12-3
Target:
Research Areas:
NEK7-IN-1 (Compound I-15) is the inhibitor for NIMA-related kinase 7 NEK7 with IC50 <100 nM. NEK7-IN-1 inhibits the IL-1β release with IC50 <50 nM .
Cat. No.: HY-101030
CAS No.: 2083621-90-1
MBM-17 is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 3 nM. It effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-55 shows antitumor activities, and no obvious toxicity to mice .
JH295 hydrate is a potent, irreversible and selective NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 770 nM. JH295 hydrate inhibits cellular Nek2 via alkylation of Cys22. JH295 hydrate is inactive against the mitotic kinases, Cdk1, Aurora B or Plk1, and does not perturb bipolar spindle assembly or the spindle assembly checkpoint . JH295 (hydrate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-101029A
CAS No.: 2083624-07-9
Target:
Research Areas:
MBM-55S is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 1 nM. MBM-55S shows a 20-fold or greater selectivity in most kinases with the exception of RSK1 (IC50=5.4 nM) and DYRK1a (IC50=6.5 nM). MBM-55S effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-55S shows antitumor activities, and no obvious toxicity to mice .
Cat. No.: HY-P71205
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PIN4; HEPVH; Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 4; Protein (Peptidyl-Prolyl Cis/Trans Isomerase) NIMA-Interacting, 4 (Parvulin); PAR14; Protein (Peptidylprolyl Cis/Trans Isomerase) NIMA-Interacting, 4 (Parvulin); PAR17; Peptidylprolyl Ci
Species:
Human
Source:
E. coli
Cat. No.: HY-P810426
Synonyms: EC 2.7.11.1, NEK7, NEK7_HUMAN, Never in mitosis A-related kinase 7, Never in mitosis gene a-related kinase 7, NIMA (never in mitosis gene a) related kinase 7, NIMA (never in mitosis gene a)-related expressed kinase 7, NIMA related protein kinase 7, NIMA-related kinase 7, NIMA-related protein kinase 7
Cat. No.: HY-P702740
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: NEK7; Never In Mitosis A-Related Kinase 7; NIMA Related Kinase 7; NIMA-Related Protein Kinase 7; NIMA (Never In Mitosis Gene A)-Related Kinase 7; NEK6-Subfamily Protein Kinase; Serine/Threonine-Protein Kinase Nek7
Species:
Human
Source:
E. coli
Cat. No.: HY-P701253
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NEK7; Never In Mitosis A-Related Kinase 7; NIMA Related Kinase 7; NIMA-Related Protein Kinase 7; NIMA (Never In Mitosis Gene A)-Related Kinase 7; NEK6-Subfamily Protein Kinase; Serine/Threonine-Protein Kinase Nek7
Species:
Human
Source:
E. coli
Cat. No.: HY-P706078
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: NEK7; Never In Mitosis A-Related Kinase 7; NIMA Related Kinase 7; NIMA-Related Protein Kinase 7; NIMA (Never In Mitosis Gene A)-Related Kinase 7; NEK6-Subfamily Protein Kinase; Serine/Threonine-Protein Kinase Nek7
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
