82

Fingolimod hydrochloride

82 Publications Verification

Cat. No.: HY-12005

CAS No.: 162359-56-0

Purity: 99.95%

Synonyms: FTY720

Target:

LPL Receptor PAK

Research Areas:

Inflammation/Immunology Cancer

Fingolimod (FTY720) hydrochloride is a sphingosine 1-phosphate (S1P) antagonist with IC₅₀ of 0.033 nM in K562 and NK cells. Fingolimod hydrochloride is also a pak1 activator and immunosuppressant .

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82

Fingolimod

82 Publications Verification

Cat. No.: HY-11063

CAS No.: 162359-55-9

Purity: 99.97%

Synonyms: FTY720 free base

Target:

LPL Receptor PAK

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Fingolimod (FTY720 free base) is a brain-penetrant sphingosine 1-phosphate (S1P) antagonist with an IC₅₀ of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant .

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64

Lenalidomide

64 Cited Publications

Cat. No.: HY-A0003

CAS No.: 191732-72-6

Synonyms: CC-5013

Target:

Molecular Glues Ligands for E3 Ligase IKZF Family Casein Kinase Apoptosis Pyroptosis MDM-2/p53 TNF Receptor

Research Areas:

Cardiovascular Disease Metabolic Disease Inflammation/Immunology Endocrinology Cancer

Lenalidomide (CC-5013) is an orally active immunomodulatory agent that binds CRBN as a molecular glue to alter substrate specificity, inducing ubiquitination and proteasome-dependent degradation of IKZF1, IKZF3 and CK1α. Lenalidomide induces apoptosis by degrading IKZF1/3, and activates p53 by degrading CK1α. Lenalidomide promotes IL-2 release and effector functions of CD8 ⁺ T/NK cells, while inhibiting TNF-α secretion and M1-type pyroptosis. Lenalidomide can be used in research related to hematological malignancies, acute liver failure and acute kidney injury .

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64

Lenalidomide hemihydrate

64 Cited Publications

Cat. No.: HY-A0003B

CAS No.: 847871-99-2

Synonyms: CC-5013 hemihydrate

Target:

Molecular Glues Ligands for E3 Ligase IKZF Family Casein Kinase Apoptosis Pyroptosis MDM-2/p53 TNF Receptor

Lenalidomide hemihydrate (CC-5013 hemihydrate) is an orally active immunomodulatory agent that binds CRBN as a molecular glue to alter substrate specificity, inducing ubiquitination and proteasome-dependent degradation of IKZF1, IKZF3 and CK1α. Lenalidomide hemihydrate induces apoptosis by degrading IKZF1/3, and activates p53 by degrading CK1α. Lenalidomide hemihydrate promotes IL-2 release and effector functions of CD8 ⁺ T/NK cells, while inhibiting TNF-α secretion and M1-type pyroptosis. Lenalidomide hemihydrate can be used in research related to hematological malignancies, acute liver failure and acute kidney injury .

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17

Eriodictyol

17 Cited Publications

Cat. No.: HY-N0637

CAS No.: 552-58-9

Synonyms: Huazhongilexone

Category:

Plants Other Families Extract Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Flavonones Phenols Polyphenols Disease Research Fields Inflammation/Immunology

Target:

Melanocortin Receptor TRP Channel

Eriodictyol ((±)-Huazhongilexone; Dihydroluteolin) is an orally active TRPV1 receptor antagonist (IC₅₀=44-47 nM, rTRPV1) with antioxidant and anti-inflammatory activities. Eriodictyol effectively inhibits lipid peroxidation and the release of proinflammatory cytokines by specifically antagonizing the TRPV1 receptor and activating the Nrf2 signaling pathway. Eriodictyol reduces the levels of ICAM-1, VEGF, eNOS and TNF-α in the retina and maintains the integrity of the blood-retinal barrier. Eriodictyol alleviates oxidative stress-induced apoptosis and hyperalgesia, enhances the activity and cytotoxicity of immune cells (such as B lymphocytes, NK cells and macrophages), and increases the levels of antioxidant enzymes simultaneously. Eriodictyol can be used in the research of diabetic retinopathy, acute lung injury and various pain-related diseases .

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16

Pitavastatin

16 Cited Publications

Cat. No.: HY-B0144A

CAS No.: 147511-69-1

Synonyms: NK-104

Target:

HMG-CoA Reductase (HMGCR) Autophagy Mitophagy Apoptosis

Research Areas:

Cardiovascular Disease Neurological Disease Metabolic Disease Cancer

Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC₅₀ of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects .

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16

Pitavastatin Calcium

16 Cited Publications

Cat. No.: HY-B0144

CAS No.: 147526-32-7

Synonyms: NK-104 hemicalcium; Pitavastatin hemicalcium

Target:

HMG-CoA Reductase (HMGCR) Autophagy Mitophagy Apoptosis

Research Areas:

Cardiovascular Disease Neurological Disease Metabolic Disease Cancer

Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC₅₀ of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin Calcium also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects .

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8

Monalizumab

8 Cited Publications

Cat. No.: HY-P99032

CAS No.: 1228763-95-8

Synonyms: IPH2201

Monalizumab (IPH2201) is an immune checkpoint inhibitor targeting Natural Killer Group 2A (NKG2A). Monalizumab, a humanized anti-NKG2A blocking mAb, increases IFN-γ production, thereby promoting NK cell effector functions. Monalizumab can be used for the research of head and neck squamous cell carcinoma (HNSCC) .

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7

MB05032

7 Cited Publications

Cat. No.: HY-16307

CAS No.: 261365-11-1

Target:

FBPase

Research Areas:

Metabolic Disease Cancer

MB05032 is a fructose-1,6-bisphosphatase (FBP1/FBPase) inhibitor with an IC₅₀ value of 16 nM. MB05032 blocks FBP1-mediated glycolysis inhibition in NK cells, restores NK cell glucose uptake, lactate production, degranulation, perforin production, and cytotoxicity against gastric cancer cells. MB05032 elevates ATP/ADP ratios, increases glucose utilization, and enhances insulin secretion in pancreatic β-cells. MB05032 increases neutrophil adhesion, phagocytosis, and mRNA abundance of HKII, ITGA9, CD36 in subclinically hypocalcemic dairy cows. MB05032 inhibits gluconeogenesis in hepatocytes, acts as the active metabolite of prodrug Managlinat dialanetil (MB06322) (HY-14955). MB05032 can be used for the research of gastric cancer, type 2 diabetes, subclinical hypocalcemia, and insulin resistance .

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5

Dextran sulfate sodium salt (MW 5000)

5 Cited Publications

Cat. No.: HY-116282

CAS No.: 9011-18-1

Purity: 99.20%

Synonyms: DSS (MW 5000); DXS (MW 5000)

Dextran sulfate sodium salt (DSS) (MW 5000) is a polymer of dehydrated glucose with a molecular weight of approximately 5000. Dextran sulfate sodium salt (DSS) with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (MW 5000) is an inhibitor of complement and coagulation pathways, and belongs to the glycosaminoglycans (GAG) family. Dextran sulfate sodium salt (MW 5000) acts as an anticoagulant, antiviral, and anti-lipemic agent. Dextran sulfate sodium salt (DSS) stops HIV-1 virus adsorption to host cells. Dextran sulfate sodium salt (MW 5000) prevents NK cell-mediated cytotoxicity. Dextran sulfate sodium salt (MW 5000) inhibits instant blood-mediated inflammatory reaction (IBMIR) .

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