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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
NNRTI binding pocket
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "NNRTI binding pocket" in MCE Product Catalog:
Cat. No.: HY-147904
CAS No.: 2459929-62-3
HIV-IN-5 (compound 5r) is a potent HIV-1 inhibitor, with an IC50 of 0.16 μM. HIV-IN-5 shows inhibition of HIV DNA-dependent DNA polymerization activity, with an IC50 of 2.18 μM. HIV-IN-5 can bind to NNIBP (NNRTIs (non-nucleoside reverse transcriptase inhibitors) binding pocket) .
Cat. No.: HY-189211
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Research Areas:
NNRT-IN-17 is a non-nucleoside HIV-1 Reverse Transcriptase inhibitor with an IC50 of 0.095 μM. NNRT-IN-17 exerts its inhibitory effect by binding to the NNRTI binding pocket and adjacent sites, and exhibits antiviral activity against wild-type and multiple NNRTI-resistant mutant strains. NNRT-IN-17 can be used for the study of HIV-1 infection (AIDS) .
Cat. No.: HY-189657
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Research Areas:
NNRT-IN-18 is an orally active HIV-1 non-nucleoside reverse transcriptase (NNRT) inhibitor with broad-spectrum anti-HIV-1 activity. NNRT-IN-18 binds to the allosteric non-nucleoside inhibitor binding pocket and inhibits RT polymerase activity with an IC50 of 0.259 μM. NNRT-IN-18 exhibits low cytotoxicity and a high selectivity index, and shows minimal inhibitory activity against major cytochrome P450 isoforms. NNRT-IN-18 retains activity against NNRTI-resistant HIV-1 mutant strains. NNRT-IN-18 can be used for research on HIV-1 infection .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
