66 Results for "

NOTCH1

" in MedChemExpress (MCE) Product Catalog:
Products (66)

66 Results for "NOTCH1" in MCE Product Catalog:

Notch 1
Notch 1
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Cat. No.: HY-P1985
CAS No.: 2408730-51-6
Target:  

Notch

Research Areas:  

Cardiovascular Disease Cancer

Notch 1 (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types [1].
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180
DAPT
DAPT
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180 Publications Verification
Cat. No.: HY-13027
CAS No.: 208255-80-5
Purity:  99.97%
Synonyms: GSI-IX
Target:  

Organoid γ-secretase Amyloid-β Autophagy Notch Apoptosis

Research Areas:  

Neurological Disease Inflammation/Immunology Cancer

DAPT (GSI-IX) is a potent and orally active γ-secretase inhibitor with IC50s of 115 nM and 200 nM for total amyloid-β (Aβ) and Aβ42, respectively. DAPT inhibits the activation of Notch 1 signaling and induces cell differentiation. DAPT also induces autophagy and apoptosis. DAPT has neuroprotection activity and has the potential for autoimmune and lymphoproliferative diseases, degenerative disease and cancers treatment [1] .
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70
Valproic acid
Valproic acid
0 Images
70 Cited Publications
Cat. No.: HY-10585
CAS No.: 99-66-1
Purity:  99.19%
Synonyms: VPA; 2-Propylpentanoic acid; Dipropylacetic acid
Category:  

Infection Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Cancer

Target:  

Organoid HDAC Autophagy Mitophagy HIV Notch Apoptosis Endogenous Metabolite

Valproic acid (VPA) is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM. Valproic acid inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid is used in the epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches [1] .
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70
Valproic acid sodium
Valproic acid sodium
0 Images
70 Cited Publications
Cat. No.: HY-10585A
CAS No.: 1069-66-5
Purity:  98.14%
Synonyms: Sodium Valproate; VPA sodium; 2-Propylpentanoic acid sodium
Category:  

Infection Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Cancer

Target:  

Organoid HDAC Autophagy Mitophagy HIV Notch Apoptosis Endogenous Metabolite

Valproic acid (Sodium Valproate) sodium is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches [1] .
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16
Tangeretin
Tangeretin
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16 Cited Publications
Cat. No.: HY-N0133
CAS No.: 481-53-8
Synonyms: Tangeritin; NSC53909; NSC618905
Category:  

Flavonoids Flavones Plants Other Families Extract Disease Research Fields Cancer

Target:  

Notch Apoptosis

Tangeretin (Tangeritin), a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models, and is a Notch-1 inhibitor.
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11
Carvacrol
Carvacrol
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11 Cited Publications
Cat. No.: HY-N0711
CAS No.: 499-75-2
Synonyms: Cymophenol
Category:  

Preservatives Monophenols Phenols Plants 500 - Internal Server Error | MedChemExpress

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