156 Results for "

NS3

" in MedChemExpress (MCE) Product Catalog:
Products (156)

156 Results for "NS3" in MCE Product Catalog:

47
Simeprevir
Simeprevir
0 Images
47 Publications Verification
Cat. No.: HY-10241
CAS No.: 923604-59-5
Purity:  98.79%
Synonyms: TMC435; TMC435350
Target:  

HCV HCV Protease SARS-CoV DNA/RNA Synthesis

Research Areas:  

Infection

Simeprevir (TMC435; TMC435350) is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (M pro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses .
loading...
    loading...
View All Sizes
46
Asunaprevir
Asunaprevir
0 Images
46 Cited Publications
Cat. No.: HY-14434
CAS No.: 630420-16-5
Purity:  99.84%
Synonyms: BMS-650032
Target:  

HCV HCV Protease SARS-CoV

Research Areas:  

Infection

Asunaprevir (BMS-650032) is a potent and orally bioavailable hepatitis C virus (HCV) NS3 protease inhibitor, with IC50 of 0.2 nM-3.5 nM . Asunaprevir inhibits SARS-CoV-2 3CL pro activity .
loading...
    loading...
View All Sizes
44
Telaprevir
Telaprevir
0 Images
44 Cited Publications
Cat. No.: HY-10235
CAS No.: 402957-28-2
Purity:  99.54%
Synonyms: VX-950
Target:  

HCV Protease HCV SARS-CoV

Research Areas:  

Infection

Telaprevir (VX-950) is a highly selective, reversible, and potent peptidomimetic inhibitor of the HCV NS3-4A protease, the steady-state inhibitory constant (Ki) of Telaprevir is 7 nM against a genotype 1 (H strain) NS3 protease domain plus a NS4A cofactor peptide [3]. Telaprevir inhibits SARS-CoV-2 3CL pro activity .
loading...
    loading...
View All Sizes
36
Pyridostatin trihydrochloride
Pyridostatin trihydrochloride
0 Images
36 Cited Publications
Cat. No.: HY-15176C
CAS No.: 2517456-88-9
Synonyms: RR82 trihydrochloride
Target:  

DNA/RNA Synthesis G-quadruplex Flavivirus Src Virus Protease

Research Areas:  

Cancer

Pyridostatin (RR82) trihydrochloride is a G-quadruplex (G4) inducer/stabilizer with a Kd of 490 nM. Pyridostatin trihydrochloride also acts as an inhibitor of Zika virus (ZIKV) NS2B-NS3 protease, with an IC50 of 11.0 μM. Pyridostatin trihydrochloride interacts with G-quadruplex structures, regulates the expression of SRC and SUB1, and induces replication- and transcription-dependent DNA damage, growth arrest, and genomic instability. Pyridostatin trihydrochloride exhibits antiproliferative and antiviral activities. Pyridostatin trihydrochloride can be used in studies related to breast cancer, cervical cancer, and Zika virus infection [3] .
loading...
    loading...
View All Sizes
36
Pyridostatin TFA
Pyridostatin TFA
0 Images
36 Cited Publications
Cat. No.: HY-15176B
CAS No.: 1472611-44-1
Purity:  99.54%
Synonyms: RR82 TFA
Target:  

DNA/RNA Synthesis G-quadruplex Flavivirus Src Virus Protease

Research Areas:  

Cancer

Pyridostatin (RR82) TFA is a G-quadruplex (G4) inducer/stabilizer with a Kd of 490 nM. Pyridostatin TFA also acts as an inhibitor of Zika virus (ZIKV) NS2B-NS3 protease, with an IC50 of 11.0 μM. Pyridostatin TFA interacts with G-quadruplex structures, regulates the expression of SRC and SUB1, and induces replication- and transcription-dependent DNA damage, growth arrest, and genomic instability. Pyridostatin TFA exhibits antiproliferative and antiviral activities. Pyridostatin TFA can be used in studies related to breast cancer, cervical cancer, and Zika virus infection [3] .
loading...
    loading...
View All Sizes
34
Boceprevir
Boceprevir
0 Images
34 Cited Publications
Cat. No.: HY-10237
CAS No.: 394730-60-0
Purity:  98.52%
Synonyms: EBP 520; SCH 503034
Target:  

HCV Protease HCV SARS-CoV

Research Areas:  

Infection

Boceprevir (EBP 520) is a potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with a Ki of 14 nM in both enzyme assay and an EC90 of 350 nM in cell-based replicon assay [3] . Boceprevir inhibits SARS-CoV-2 3CL pro activity .
loading...
    loading...
View All Sizes
30
Grazoprevir
Grazoprevir
0 Images
30 Cited Publications
Cat. No.: HY-15298
CAS No.: 1350514-68-9
Purity:  99.99%
Synonyms: MK-5172
Target:  

HCV Protease HCV SARS-CoV

Research Areas:  

Infection

Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively . Grazoprevir inhibits SARS-CoV-2 3CL pro activity [3].
loading...
    loading...
View All Sizes
30
Grazoprevir potassium salt
Grazoprevir potassium salt
0 Images
30 Cited Publications
Cat. No.: HY-15298A
CAS No.: 1206524-86-8
Purity:  99.63%
Synonyms: MK-5172 potassium salt
Target:  

HCV HCV Protease SARS-CoV

Research Areas:  

Infection

Grazoprevir potassium salt (MK-5172 potassium salt) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively . Grazoprevir potassium salt inhibits SARS-CoV-2 3CL pro activity [3].
loading...
    loading...
View All Sizes
30
Grazoprevir hydrate
Grazoprevir hydrate
0 Images
30 Cited Publications
Cat. No.: HY-15298B
CAS No.: 1350462-55-3
Purity:  99.99%
Synonyms: MK-5172 hydrate
Target:  

HCV HCV Protease SARS-CoV

Research Areas:  

Infection

Grazoprevir hydrate (MK-5172 hydrate) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively . Grazoprevir hydrate inhibits SARS-CoV-2 3CL pro activity [3].
loading...
    loading...
View All Sizes
20
Danoprevir
Danoprevir
0 Images
20 Cited Publications
Cat. No.: HY-10238
CAS No.: 850876-88-9
Purity:  99.67%
Synonyms: ITMN-191; R7227; RO5190591; RG7227
Target:  

HCV Protease HCV SARS-CoV

Research Areas:  

Infection

Danoprevir (ITMN-191) is an orally active NS3/4A protease inhibitor for hepatitis C virus (HCV) with an IC50 of 0.29 nM and is selective for NS3/4A over a panel of 53 proteases (IC50 higher than 10 μM). Danoprevir (ITMN-191) inhibits HCV genotypes 1a, 1b, 4, 5, and 6 (IC50s=0.2-0.4 nM) as well as 2b and 3a (IC50s=1.6, 3.5 nM) . Danoprevir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 0.05 μM [3].
loading...
    loading...
View All Sizes
13
Glecaprevir
Glecaprevir
0 Images
13 Cited Publications
Cat. No.: HY-17634
CAS No.: 1365970-03-1
Synonyms: ABT-493
Target:  

HCV HCV Protease SARS-CoV

Research Areas:  

Infection

Glecaprevir is a novel HCV NS3/4A protease inhibitor, with IC50 values ranging from 3.5 to 11.3 nM. Glecaprevir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 4.09 μM .
loading...
    loading...
View All Sizes
13
Paritaprevir
Paritaprevir
0 Images
13 Cited Publications
Cat. No.: HY-12594
CAS No.: 1216941-48-8
Purity:  99.87%
Synonyms: ABT-450; Veruprevir
Target:  

HCV Protease HCV SARS-CoV

Research Areas:  

Infection

Paritaprevir (ABT-450) is a potent, orally active and antiviral non-structural protein 3/4A (NS3/4A) protease inhibitor with EC50s of 1 and 0.21 nM against HCV 1a and 1b, respectively. Paritaprevir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 1.31 μM. Paritaprevir is metabolized primarily by cytochrome P450 (CYP) 3A. The plasma concentration and half-life of Paritaprevir can be enhanced by Ritonavir (a CYP450 inhibitor) [3] .
loading...
    loading...
View All Sizes
12
Palmatine chloride
Palmatine chloride
0 Images
12 Cited Publications
Cat. No.: HY-N0110
CAS No.: 10605-02-4
Category:  

Rutaceae Extract Alkaloids 500 - Internal Server Error | MedChemExpress

Oops!

Sorry, Something went wrong on our server.
Our team has been notified and is working to fix the issue.