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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
NUDT1
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "NUDT1" in MCE Product Catalog:
Target:
Research Areas:
BAY-707, a chemical probe, is a substrate-competitive, highly potent and selective inhibitor of MTH1(NUDT1) with an IC50 of 2.3 nM. BAY-707 has a good pharmacokinetic (PK) profile to other MTH1 compounds and is well-tolerated in mice, but shows a clear lack of in vitro or in vivo anticancer efficacy [1].
Cat. No.: HY-RS09661
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NUDT1 Human Pre-designed siRNA Set A contains three designed siRNAs for NUDT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS18535
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Nudt1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nudt1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS25017
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Nudt1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nudt1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-187054
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NUDT1 ligand-1 is a NUDT1 ligand and can be used for the synthesis of PROTACs, such as LC-1-40 (HY-158062) [1].
Cat. No.: HY-158062
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LC-1-40 is a selective NUDT1 PROTAC degrader with a DC50 of 0.97 nM. LC-1-40 recruits NUDT1 to the CRBN E3 ubiquitin ligase complex and mediates its degradation via a proteasome-dependent pathway. LC-1-40 induces increased nucleotide damage and Apoptosis in tumors. LC-1-40 can be used in studies related to Mycn-amplified neuroblastoma [1].
Cat. No.: HY-189207
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NUDT1-IN-1 is an inhibitor of NUDT1 (MTH1) with a pIC50 value of 9.785. NUDT1-IN-1 can be applied in cancer research [1].
Cat. No.: HY-P74740
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NUDT1; Methylated Purine Nucleoside Triphosphate Hydrolase; Prev. MTH1; 8-Oxo-7,8-Dihydrodeoxyguanosine Triphosphatase; 7,8-Dihydro-8-Oxoguanine Triphosphatase; Nucleoside Diphosphate-Linked Moiety X Motif 1; Nudix Motif 1; 8-Oxo-7,8-Dihydroguanosine Triphosphatase; 8-Oxo-DGTPase; 2-Hydroxy-DATP Diphosphatase; Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1; MutT Human Homolog 1; Nucleoside Diphosphate-Linked Moiety X-Type Motif 1; Nudix Hydrolase 1; Oxidized Purine Nucleoside Triphosphate Hydrolase
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
