168 Results for "

Neuroprotection

" in MedChemExpress (MCE) Product Catalog:
Products (168)

168 Results for "Neuroprotection" in MCE Product Catalog:

180
DAPT
DAPT
0 Images
180 Publications Verification
Cat. No.: HY-13027
CAS No.: 208255-80-5
Purity:  99.97%
Synonyms: GSI-IX
Target:  

Organoid γ-secretase Amyloid-β Autophagy Notch Apoptosis

Research Areas:  

Neurological Disease Inflammation/Immunology Cancer

DAPT (GSI-IX) is a potent and orally active γ-secretase inhibitor with IC50s of 115 nM and 200 nM for total amyloid-β (Aβ) and Aβ42, respectively. DAPT inhibits the activation of Notch 1 signaling and induces cell differentiation. DAPT also induces autophagy and apoptosis. DAPT has neuroprotection activity and has the potential for autoimmune and lymphoproliferative diseases, degenerative disease and cancers treatment .
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53
Semaglutide
Semaglutide
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53 Cited Publications
Cat. No.: HY-114118
CAS No.: 910463-68-2
Purity:  99.84%
Target:  

GLP Receptor Insulin Receptor α-synuclein Apoptosis p38 MAPK Autophagy Bcl-2 Family

Research Areas:  

Neurological Disease Metabolic Disease Cancer

Semaglutide is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer .
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53
Semaglutide acetate
Semaglutide acetate
0 Images
53 Cited Publications
Cat. No.: HY-114118B
CAS No.: 1997361-85-9
Purity:  99.92%
Target:  

GLP Receptor Insulin Receptor α-synuclein Apoptosis p38 MAPK Autophagy Bcl-2 Family

Research Areas:  

Neurological Disease Metabolic Disease Cancer

Semaglutide acetate is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide acetate promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide acetate also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide acetate has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide acetate can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer .
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53
Semaglutide TFA
Semaglutide TFA
0 Images
53 Cited Publications
Cat. No.: HY-114118A
Purity:  99.92%
Target:  

GLP Receptor Insulin Receptor α-synuclein Apoptosis p38 MAPK Autophagy Bcl-2 Family

Research Areas:  

Neurological Disease Metabolic Disease Cancer

Semaglutide TFA is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide TFA promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide TFA also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide TFA has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide TFA can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer .
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36
Fisetin
Fisetin
0 Images
36 Cited Publications
Cat. No.: HY-N0182
CAS No.: 528-48-3
Category:  

Flavonols Neurological Disease Anti-aging Rosaceae Extract Metabolic Disease Plants Flavonoids Phenols Polyphenols Disease Research Fields Inflammation/Immunology Cancer Fragaria × ananassa Duch.

Target:  

Sirtuin PPAR TNF Receptor

Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.
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36
Fisetin quarterhydrate
Fisetin quarterhydrate
0 Images
36 Cited Publications
Cat. No.: HY-N0182A
Category:  

Plants

Target:  

Sirtuin PPAR TNF Receptor

Fisetin quarterhydrate is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.
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21
Echinacoside
Echinacoside
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21 Cited Publications
Cat. No.: HY-N0020
CAS No.: 82854-37-3
Category:  

Orobanchaceae Extract Simple Phenylpropanols Cistanche deserticola Ma Phenols Polyphenols Phenylpropanoids Plants

Target:  

Wnt Reactive Oxygen Species (ROS)

Echinacoside, one of the phenylethanoids isolated from the stems of Cistanche deserticola, effectively inhibits Wnt/β-catenin signaling. Echinacoside elicits neuroprotection by activating Trk receptors and their downstream signal pathways. Antiosteoporotic activity .
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12
Sesamin
Sesamin
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12 Cited Publications
Cat. No.: HY-N0121
CAS No.: 607-80-7
Category:  

Neurological Disease Anti-aging Pedaliaceae Extract Sesamum indicum Linn. Lignans Phenylpropanoids Plants Disease Research Fields

Target:  

Stearoyl-CoA Desaturase (SCD)

Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia .
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12
Palmatine chloride
Palmatine chloride
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12 Cited Publications
Cat. No.: HY-N0110
CAS No.: 10605-02-4
Category:  

Rutaceae Extract Alkaloids Phellodendron amurense Rupr. Plants Disease Research Fields Isoquinoline Alkaloids Cancer

Target:  

mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite

Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC50s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC50 of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .
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12
Palmatine hydroxide
Palmatine hydroxide
0 Images
12 Cited Publications
Cat. No.: HY-N0110B
CAS No.: 131-04-4
Category:  

Rutaceae Extract Alkaloids Phellodendron amurense Rupr. Other Alkaloids Plants

Target:  

mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite

Palmatine hydroxide is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC50s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine hydroxide can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC50 of 96 μM. Palmatine hydroxide shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .
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10
Hydroxytyrosol
Hydroxytyrosol
0 Images
10 Cited Publications
Cat. No.: HY-N0570
CAS No.: 10597-60-1
Synonyms: DOPET; 3,4-Dihydroxyphenethyl alcohol; 3-Hydroxytyrosol
Category:  

Infection Canarium album (Lour.) Rauesch. Burseraceae Extract Phenols Polyphenols Plants Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Apoptosis Bacterial Reactive Oxygen Species (ROS) SARS-CoV Estrogen Receptor/ERR

Hydroxytyrosol (DOPET; 3,4-Dihydroxyphenethyl alcohol) is an orally active, blood-brain barrier-permeable multi-active compound with multiple effects including antibacterial, antioxidant, anti-platelet aggregation, and neuroprotective activities. Hydroxytyrosol not only inhibits the growth of Vibrio by increasing bacterial membrane permeability, but also interacts with DNA and mediates supercoiled DNA relaxation. Meanwhile, Hydroxytyrosol effectively reduces thrombosis and inhibits lipid oxidation by inhibiting COX activity and promoting vascular nitric oxide production. In terms of neuroprotection, Hydroxytyrosol significantly alleviates neuronal apoptosis and inflammatory responses by up-regulating the expression level of ERβ, thereby improving cognitive function in Alzheimer's disease models. Hydroxytyrosol has been widely used in scientific research related to Vibrio infection, arterial thrombosis, Alzheimer's disease and other related fields .
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9
Curculigoside
Curculigoside
0 Images
9 Cited Publications
Cat. No.: HY-N0705
CAS No.: 85643-19-2
Category:  

Curculigo orchioides Gaertn. Monophenols Neurological Disease Amaryllidaceae Extract Phenols Plants Disease Research Fields Cancer

Target:  

JAK STAT NF-κB

Curculigoside is the main saponin in C. orchioide, exerts significant antioxidant, anti-osteoporosis, antidepressant and neuroprotection effects. Curculigoside possesses significant anti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-κB signaling pathway .
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6
9-cis-Retinoic acid
9-cis-Retinoic acid
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6 Cited Publications
Cat. No.: HY-15128
CAS No.: 5300-03-8
Purity:  99.56%
Synonyms: Alitretinoin
Category:  

Terpenoids Diterpenoids Endogenous metabolite Disease Research Fields Inflammation/Immunology Cancer

Target:  

RAR/RXR Apoptosis Endogenous Metabolite

9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist. 9-cis-Retinoic acid induces apoptosis, regulates cell cycle and has anticancer, anti-inflammatory and neuroprotection activities .
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5
Guanidinoethyl sulfonate
Guanidinoethyl sulfonate
0 Images
5 Cited Publications
Cat. No.: HY-113329
CAS No.: 543-18-0
Purity:  ≥98.0%
Synonyms: Taurocyamine
Category:  

Natural Products Other disease Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

Guanidinoethyl sulfonate (Taurocyamine) is an orally available, blood-brain permeable competitive inhibitor of taurine transporters and a competitive antagonist of glycine receptors (GlyR) (IC50=565 μM). Guanidinoethyl sulfonate has both weak agonist and antagonist effects on GABAA receptors. Guanidinoethyl sulfonate inhibits taurine transmembrane transport and competitively binds to the GlyR ligand binding domain, thereby blocking glycine-mediated chloride influx, and may regulate brain pH to exert neuroprotective effects. Guanidinoethyl sulfonate can be used for neuroprotection studies of ischemic brain injury .
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5
Dihydrocapsaicin
Dihydrocapsaicin
0 Images
5 Cited Publications
Cat. No.: HY-N0361
CAS No.: 19408-84-5
Category:  

Alkaloids Capsicum annuum L. Monophenols Other Alkaloids Metabolic Disease Phenols Plants Disease Research Fields Solanaceae Extract

Target:  

Environmental Pollutants Caspase Akt Apoptosis Reactive Oxygen Species (ROS) TRP Channel Bcl-2 Family PI3K

Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .
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5
Nicotiflorin
Nicotiflorin
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5 Cited Publications
Cat. No.: HY-N1475
CAS No.: 17650-84-9
Category:  

Flavonols Flavonoids Carthamus tinctorius L. Phenols Polyphenols Plants Compositae Extract

Target:  

Others

Nicotiflorin is a flavonoid glycoside extracted from a traditional Chinese medicine Carthamus tinctorius. Nicotiflorin shows potent antiglycation activity and neuroprotection effects.
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5
CYM5442
CYM5442
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5 Cited Publications
Cat. No.: HY-10968
CAS No.: 1094042-01-9
Purity:  98.83%
Target:  

LPL Receptor

Research Areas:  

Neurological Disease

CYM5442 is a potent, highly-selective and orally active sphingosine 1-phosphate (S1P1) receptor agonist with an EC50 of 1.35 nM. CYM5442 is inactive against S1P2, S1P3, S1P4, and S1P5. CYM5442 activates S1P1-dependent p42/p44-MAPK phosphorylation. CYM5442 exerts retinal neuroprotection. CYM5442 can easily penetrate the central nervous system (CNS) .
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5
CYM5442 hydrochloride
CYM5442 hydrochloride
0 Images
5 Cited Publications
Cat. No.: HY-10968A
CAS No.: 1783987-80-3
Target:  

LPL Receptor

Research Areas:  

Neurological Disease

CYM5442 hydrochloride is a potent, highly-selective and orally active sphingosine 1-phosphate (S1P1) receptor agonist with an EC50 of 1.35 nM. CYM5442 hydrochloride is inactive against S1P2, S1P3, S1P4, and S1P5. CYM5442 hydrochloride activates S1P1-dependent p42/p44-MAPK phosphorylation. CYM5442 exerts retinal neuroprotection. CYM5442 hydrochloride can easily penetrate the central nervous system (CNS) .
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4
Notoginsenoside R1
Notoginsenoside R1
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4 Cited Publications
Cat. No.: HY-N0615
CAS No.: 80418-24-2
Synonyms: Sanchinoside R1; Sanqi glucoside R1
Category:  

Triterpenes Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Terpenoids Other Diseases Plants Disease Research Fields Araliaceae Extract

Target:  

Amyloid-β Apoptosis

Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H2O2-induced oxidative damage in PC12 cells .
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4
Dehydroepiandrosterone sulfate
Dehydroepiandrosterone sulfate
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4 Cited Publications
Cat. No.: HY-113416
CAS No.: 651-48-9
Purity:  99.93%
Synonyms: DHEA sulfate; Prasterone sulfate
Category:  

Human Gut Microbiota Metabolites Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Steroids

Target:  

GABA Receptor Sigma Receptor iGluR PPAR NF-κB

Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) is a neurosteroid and the main secretion product of the adrenal gland. Dehydroepiandrosterone sulfate has both non-competitive antagonist activity of GABAA receptor and agonist activity of σ1 receptor. Dehydroepiandrosterone sulfate can partially penetrate the blood-brain barrier, inhibit GABAA receptor-mediated chloride influx, enhance NMDA receptor activity through σ1 receptors, exert anti-inflammatory, anti-glucocorticoid and antidepressant effects, and increase convulsive sensitivity. Dehydroepiandrosterone sulfate participates in neuroprotection, neurite growth regulation and catecholamine secretion regulation, and can be used in the study of depression, post-traumatic stress disorder (PTSD), Alzheimer's disease, etc. Dehydroepiandrosterone sulfate may also be a biomarker for cardiovascular disease mortality, and its concentration is independently and negatively correlated with mortality .
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