18 Results for "

Nigericin

" in MedChemExpress (MCE) Product Catalog:
Products (18)

18 Results for "Nigericin" in MCE Product Catalog:

264
Nigericin
Nigericin
0 Images
264 Publications Verification
Cat. No.: HY-127019
CAS No.: 28380-24-7
Purity:  99.43%
Target:  

Potassium Channel NOD-like Receptor (NLR) Bacterial Antibiotic Pyroptosis Wnt β-catenin

Research Areas:  

Infection Cancer

Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K +/H + ionophore, promoting K +/H + exchange across mitochondrial membranes. Nigericin is a NLRP3 activator. Nigericin shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin induces pyroptosis through caspase 1/GSDMD in TNBC .
loading...
    loading...
View All Sizes
264
Nigericin sodium salt
Nigericin sodium salt
0 Images
264 Publications Verification
Cat. No.: HY-100381
CAS No.: 28643-80-3
Purity:  99.37%
Category:  

Infection Microorganisms Antibiotics Disease Research Disease Research Fields Other Antibiotics Cancer

Target:  

Potassium Channel NOD-like Receptor (NLR) Bacterial Antibiotic Pyroptosis Wnt β-catenin

Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K +/H + ionophore, promoting K +/H + exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin sodium salt induces pyroptosis through caspase 1/GSDMD in TNBC .
loading...
    loading...
View All Sizes
11
NLRP3/AIM2-IN-3
NLRP3/AIM2-IN-3
0 Images
11 Cited Publications
Cat. No.: HY-144226
CAS No.: 1787787-60-3
Purity:  98.23%
Target:  

NOD-like Receptor (NLR) AIM2 Pyroptosis

Research Areas:  

Inflammation/Immunology

NLRP3/AIM2-IN-3 (compound 59) is a potent inhibitor with differential species specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. NLRP3/AIM2-IN-3 shows inhibitory efficacy against pyroptosis in THP-1 macrophages stimulated with LPS/nigericin, with an IC50 of 0.077 ± 0.008 μM. NLRP3/AIM2-IN-3 disturbs the interaction of NLRP3 or AIM2 with the adaptor protein ASC and inhibited ASC oligomerization .
loading...
    loading...
View All Sizes
3
Icariside I
Icariside I
0 Images
3 Cited Publications
Cat. No.: HY-N1939
CAS No.: 56725-99-6
Synonyms: Icarisid I
Category:  

Flavonols Flavonoids Monophenols Other Diseases Phenols 500 - Internal Server Error | MedChemExpress

Oops!

Sorry, Something went wrong on our server.
Our team has been notified and is working to fix the issue.