159 Results for "

Nrf2/HO-1

" in MedChemExpress (MCE) Product Catalog:
Products (159)

159 Results for "Nrf2/HO-1" in MCE Product Catalog:

82
Sulforaphane
Sulforaphane
0 Images
82 Publications Verification
Cat. No.: HY-13755
CAS No.: 4478-93-7
Purity:  98.87%
Category:  

Natural Products Plant Other Families Extract Disease Research Fields Inflammation/Immunology

Target:  

HDAC Keap1-Nrf2 Apoptosis Bcl-2 Family Caspase Reactive Oxygen Species (ROS)

Sulforaphane is an orally active inducer of the Keap1/Nrf2/ARE pathway. Sulforaphane promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. Through the activation of the Keap1/Nrf2/ARE pathway and further induction of HO-1 expression, Sulforaphane protects the heart. Sulforaphane suppresses high glucose-induced pancreatic cancer through AMPK-dependent signal transmission. Sulforaphane exhibits both anticancer and anti-inflammatory properties [1] [2] .
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44
Bardoxolone methyl
Bardoxolone methyl
0 Images
44 Cited Publications
Cat. No.: HY-13324
CAS No.: 218600-53-4
Purity:  98.92%
Synonyms: RTA 402; NSC 713200; CDDO Methyl ester
Target:  

Keap1-Nrf2 SARS-CoV Virus Protease

Research Areas:  

Infection Neurological Disease Inflammation/Immunology

Bardoxolone methyl (RTA 402) is an orally active and blood-brain-barrier-penetrant activator of Nrf2 and an inhibitor of SARS-CoV-2 3CL protease. Bardoxolone methyl inhibits SARS-CoV-2 replication in Vero cells with an EC50 value of 0.29 μM. Bardoxolone methyl increases levels of pNrf2 and HO-1, inhibits inflammatory mediators like pNFκB and MCP-1. Bardoxolone methyl activates the Nrf2 pathway to enhance antioxidant and anti-inflammatory responses, inhibits viral replication, and improves mitochondrial function. Bardoxolone methyl can be used in research on chemotherapy-induced neuropathic pain (CINP), COVID-19, and chronic kidney disease (CKD) [1] [2] .
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12
Sophocarpine
Sophocarpine
0 Images
12 Cited Publications
Cat. No.: HY-N0103
CAS No.: 6483-15-4
Category:  

Infection Alkaloids Leguminosae/Fabaceae Extract Sophora flavescens Aiton Extract Piperidine Alkaloids Plant Disease Research Fields Inflammation/Immunology

Target:  

Autophagy Apoptosis NF-κB PI3K Akt MEK ERK PTEN

Sophocarpine is a PTEN activator and an inhibitor of PI3K/Akt, MEK/ERK, and NF-κB signaling pathways. Sophocarpine upregulates PTEN expression and inhibits PI3K/Akt phosphorylation, arrests tumor cell cycle and induces apoptosis. Sophocarpine inhibits MEK/ERK phosphorylation and VEGF secretion, reducing tumor cell migration. Sophocarpine can also inhibit NF-κB activation and p38 and JNK phosphorylation, reduce the expression of inflammatory factors such as iNOS and COX-2, and activate the Nrf2/HO-1 pathway to reduce oxidative stress. Sophocarpine has anti-tumor, anti-inflammatory, antioxidant and anti-apoptotic effects, and can be used in the research of cancers such as glioblastoma and colorectal cancer, inflammation-related diseases, and Doxorubicin (HY-15142A)-induced cardiac damage [1] [2] .
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12
Sophocarpine monohydrate
Sophocarpine monohydrate
0 Images
12 Cited Publications
Cat. No.: HY-N0103A
CAS No.: 145572-44-7
Category:  

Infection Alkaloids Leguminosae/Fabaceae Extract Piperidine Alkaloids Plant Sophora japonica L. Extract Disease Research Fields Inflammation/Immunology

Target:  

Autophagy Apoptosis NF-κB PI3K Akt MEK ERK

Sophocarpine monohydrate is a PTEN activator and an inhibitor of PI3K/Akt, MEK/ERK, and NF-κB signaling pathways. Sophocarpine monohydrate upregulates PTEN expression and inhibits PI3K/Akt phosphorylation, arrests tumor cell cycle and induces apoptosis. Sophocarpine monohydrate inhibits MEK/ERK phosphorylation and VEGF secretion, reducing tumor cell migration. Sophocarpine monohydrate can also inhibit NF-κB activation and p38 and JNK phosphorylation, reduce the expression of inflammatory factors such as iNOS and COX-2, and activate the Nrf2/HO-1 pathway to reduce oxidative stress. Sophocarpine monohydrate has anti-tumor, anti-inflammatory, antioxidant and anti-apoptotic effects, and can be used in the research of cancers such as glioblastoma and colorectal cancer, inflammation-related diseases, and Doxorubicin (HY-15142A)-induced cardiac damage [1] [2] .
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10
Forsythiaside A
Forsythiaside A
0 Images
10 Cited Publications
Cat. No.: HY-N0028
CAS No.: 79916-77-1
Category:  

Plant Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Oleaceae Extract Disease Research Fields Inflammation/Immunology Forsythia suspensa (Thunb.) Vahl Extract

Target:  

Others

Forsythiaside A is an orally active phenylethanoid glycoside isolated from the dried fruits of Forsythia suspensa. Forsythiaside A is also an inhibitor of COX-2 and has anti-inflammatory, antioxidant and neuroprotective effects. Forsythiaside A prevents neuroinflammation and apoptosis caused by Aβ25-35 damage and may be used in Alzheimer's disease (AD) research. Forsythiaside A also activates the Nrf2/HO-1 signaling pathway and inhibits OVA-induced asthma in mice. Forsythiaside A inhibits the interaction between KLRB1 and CLEC2D [1] [2] .
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10
Danshensu
Danshensu
0 Images
10 Cited Publications
Cat. No.: HY-N1913
CAS No.: 76822-21-4
Synonyms: Dan shen suan A; Salvianic acid A
Category:  

Plant Simple Phenylpropanols Phenols Polyphenols Salvia miltiorrhiza Bunge Extract Phenylpropanoids Disease Research Fields Cancer Labiatae Extract

Target:  

Keap1-Nrf2 NF-κB Reactive Oxygen Species (ROS) SARS-CoV Apoptosis

Danshensu (Dan shen suan A), an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu displays a potent antiviral activity against SARS-CoV-2 with EC50 of 0.97 μM. Danshensu has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research [1] [2] .
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10
Danshensu sodium
Danshensu sodium
0 Images
10 Cited Publications
Cat. No.: HY-N1913A
CAS No.: 81075-52-7
Synonyms: Dan shen suan A sodium; Salvianic acid A sodium
Category:  

Plant Simple Phenylpropanols Phenols Polyphenols Salvia miltiorrhiza Bunge Extract Phenylpropanoids Labiatae Extract

Target:  

Keap1-Nrf2 NF-κB Reactive Oxygen Species (ROS) SARS-CoV Apoptosis

Danshensu (Dan shen suan A) sodium, an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu sodium reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu sodium displays a potent antiviral activity against SARS-CoV-2 with EC50 of 0.97 μM. Danshensu sodium has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research [1] [2] .
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8
Sappanone A
Sappanone A
0 Images
8 Cited Publications
Cat. No.: HY-113556
CAS No.: 102067-84-5
Purity:  99.87%
Category:  

Leguminosae/Fabaceae Extract Plant Flavonoids Caesalpinia sappan L. Extract Disease Research Fields Inflammation/Immunology Isoflavones

Target:  

Phosphodiesterase (PDE) NF-κB Keap1-Nrf2 Reactive Oxygen Species (ROS) TNF Receptor Nuclear Factor of activated T Cells (NFAT) Akt ERK p38 MAPK NO Synthase Interleukin Related COX JNK

Sappanone A is an orally active homoisoflavone found in sappan L. Sappanone A is a PDE4 and NF-κB inhibitor with anti-inflammatory and antioxidant effect. Sappanone A induces HO-1 expression through activation of Nrf2 pathway. Sappanone A also inhibits RANKL-induced osteoclastogenesis. Sappanone A has great potential in the research of inflammation-related and cardiovascular [1] [2] .
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8
Rutaecarpine
Rutaecarpine
0 Images
8 Cited Publications
Cat. No.: HY-N0147
CAS No.: 84-26-4
Synonyms: Rutecarpine
Category:  

Rutaceae Extract Alkaloids Plant Evodia rutaecarpa (Juss.) Benth./Tetradium ruticarpum (A. Jussieu) T. G. Hartley Extract Disease Research Fields Cancer Indole Alkaloids

Target:  

COX Keap1-Nrf2

Rutaecarpine, an alkaloid of Evodia rutaecarpa, is an inhibitor of COX-2 with an IC50 value of 0.28 μM. Rutaecarpine can target and activate the NRF2/HO-1 pathway to reduce craniofacial injury. Rutaecarpine sttenuates oxidative stress-induced traumatic brain injury (TBI) and reduces secondary injury via the PGK1/KEAP1/NRF2 signaling pathway. Rutaecarpine can cross the blood-brain barrier (BBB).
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8
Pyridoxine
Pyridoxine
0 Images
8 Cited Publications
Cat. No.: HY-B1328
CAS No.: 65-23-6
Synonyms: Pyridoxol
Category:  

Natural Products Disease markers Nervous System Disorder Microorganism Endogenous metabolite Cardiovascular System Disorder

Target:  

Environmental Pollutants Endogenous Metabolite Keap1-Nrf2

Pyridoxine (Pyridoxol) is one of the components of vitamin B6. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
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8
Pyridoxine hydrochloride
Pyridoxine hydrochloride
0 Images
8 Cited Publications
Cat. No.: HY-N0682
CAS No.: 58-56-0
Synonyms: Vitamin B6 hydrochloride
Category:  

Alkaloids Pyridine Alkaloids Endogenous metabolite

Target:  

Environmental Pollutants Endogenous Metabolite Keap1-Nrf2

Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
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7
Loganin
Loganin
0 Images
7 Cited Publications
Cat. No.: HY-N0512
CAS No.: 18524-94-2
Synonyms: Loganoside
Category:  

Plant Cornus officinalis Sieb. et Zucc. Extract Iridoids Terpenoids Disease Research Fields Cornaceae Extract Cancer

Target:  

Reactive Oxygen Species (ROS) TNF Receptor Interleukin Related

Loganin is a type of iridoid glycoside compound that possesses anti-inflammatory, antioxidant, and antitumor properties, and offers protective effects against acute lung injury and pulmonary fibrosis. Loganin exerts its protective effects against LPS (HY-D1056)-mediated inflammation and oxidative stress by upregulating the Nrf2/HO-1 signaling pathway, and it reduces neuroinflammation caused by spinal cord injury (SCI) [1] [2] .
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5
Garcinone D
Garcinone D
0 Images
5 Cited Publications
Cat. No.: HY-N6953
CAS No.: 107390-08-9
Category:  

Plant Xanthones Guttiferae Extract Phenols Polyphenols Garcinia mangostana Linn. Extract

Target:  

STAT Keap1-Nrf2 Reactive Oxygen Species (ROS)

Garcinone D is an activator of the STAT3/Cyclin D1 and Nrf2/HO-1 pathways, and an inhibitor of CDK2/CyclinE1 (IC50 for CDK2/CyclinE1 is 28.23 μM). Garcinone D promotes neural stem cell proliferation by activating STAT3 phosphorylation and Cyclin D1 expression and enhancing the Nrf2/HO-1 signaling pathway. In addition, Garcinone D blocks the tumor cell cycle by inhibiting CDK2/CyclinE1. Garcinone D can promote the proliferation of C17.2 neural stem cells and inhibit prostate and breast cancer [1] [2].
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4
Deltamethrin
Deltamethrin
0 Images
4 Cited Publications
Cat. No.: HY-B1971
CAS No.: 52918-63-5
Synonyms: Decamethrin
Category:  

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology Cancer

Target:  

Environmental Pollutants Calcium Channel Caspase Bcl-2 Family NF-κB Interleukin Related Endogenous Metabolite Apoptosis

Deltamethrin (Decamethrin) is an orally active synthetic pyrethroid insecticide. Deltamethrin induces oxidative stress and results in inflammation and apoptosis via inhibiting Nrf2/HO-1 pathway. Deltamethrin has an anticancer effect by inducing apoptosis. Deltamethrin can be used extensively in pest control [1] [2] .
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3
Phosphocreatine
Phosphocreatine
0 Images
3 Cited Publications
Cat. No.: HY-D0885
CAS No.: 67-07-2
Synonyms: Creatine pHOsphate; CreatinepHOspHOric acid
Category:  

Ketones, Aldehydes, Acids Animal Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite MAP3K Akt Mitochondrial Metabolism ERK Apoptosis ROS Kinase

Phosphocreatine (creatine phosphate) is an organic compound found in vertebrate skeletal muscles. Phosphocreatine enhances antioxidant activity, and activates the TAK1 pathway to protect the heart. Phosphocreatine normalizing mitochondrial function and reducing oxidative stress via Akt mediated Nrf2/HO-1 pathway. Phosphocreatine provides renal protection by suppressing Apoptosis and ROS (Reactive Oxygen Species) generation through ERK mediated mediated Nrf-2/HO-1 pathway. [1] [2] .
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3
Phosphocreatine disodium
Phosphocreatine disodium
0 Images
3 Cited Publications
Cat. No.: HY-D0885B
CAS No.: 922-32-7
Synonyms: Disodium creatine pHOsphate
Category:  

Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite MAP3K Akt Mitochondrial Metabolism ERK Apoptosis ROS Kinase

Phosphocreatine (disodium) is an organic compound found in vertebrate skeletal muscles. Phosphocreatine (disodium) enhances antioxidant activity, and activates the TAK1 pathway to protect the heart. Phosphocreatine (disodium) normalizing mitochondrial function and reducing oxidative stress via Akt mediated Nrf2/HO-1 pathway. Phosphocreatine (disodium) provides renal protection by suppressing Apoptosis and ROS (Reactive Oxygen Species) generation through ERK mediated mediated Nrf-2/HO-1 pathway. [1] [2] .
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3
Spinosin
Spinosin
0 Images
3 Cited Publications
Cat. No.: HY-N0651
CAS No.: 72063-39-9
Category:  

Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H.F.Chow. Extract Plant Flavonoids Flavones Phenols Polyphenols Rhamnaceae Extract

Target:  

Amyloid-β

Spinosyn is a kind of effective C-saccharide, which has a protective effect. Spinosyn is active through Nrf2/HO-1 pathway inhibition Aβ1-42's production and combination [1] [2] [3 ].
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3
Gomisin J
Gomisin J
0 Images
3 Cited Publications
Cat. No.: HY-N0385
CAS No.: 66280-25-9
Category:  

Cardiovascular Disease Plant Monophenols Lignans Schisandra chinensis (Turcz.) Baill. Extract Phenols Phenylpropanoids Schisandraceae Extract Disease Research Fields

Target:  

NO Synthase AMPK CaMK NF-κB Keap1-Nrf2

Gomisin J is a Schisandra chinensis-derived lignan that can inhibit multiple targets such as eNOS, AMPK (LKB1, CaMKIIβ), fetuin-A, NF-κB, Nrf2/HO-1, and can pass through the blood-brain barrier. Gomisin J increases NO bioavailability by activating eNOS, regulates lipid metabolism by activating the AMPK pathway, inhibits fetuin-A and NF-κB to exert anti-inflammatory effects, and activates Nrf2/HO-1 to enhance antioxidant capacity. Gomisin J has the activities of anti-hypertension, regulating liver lipid metabolism, and reducing cerebral ischemia-reperfusion injury, and can be used for research on hypertension, non-alcoholic fatty liver disease, cerebral ischemia-reperfusion injury, etc [1] [2] .
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3
Phosphocreatine disodium hydrate
Phosphocreatine disodium hydrate
0 Images
3 Cited Publications
Cat. No.: HY-D0885D
CAS No.: 19333-65-4
Category:  

Ketones, Aldehydes, Acids Animal Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite MAP3K Akt Mitochondrial Metabolism ERK Apoptosis ROS Kinase

Phosphocreatine (disodium hydrate) is an organic compound found in vertebrate skeletal muscles. Phosphocreatine (disodium hydrate) enhances antioxidant activity, and activates the TAK1 pathway to protect the heart. Phosphocreatine (disodium hydrate) normalizing mitochondrial function and reducing oxidative stress via Akt mediated Nrf2/HO-1 pathway. Phosphocreatine (disodium hydrate) Phosphocreatine (disodium hydrate) provides renal protection by suppressing Apoptosis and ROS (Reactive Oxygen Species) generation through ERK mediated mediated Nrf-2/HO-1 pathway. [1] [2] .
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3
Monotropein
Monotropein
0 Images
3 Cited Publications
Cat. No.: HY-N0648
CAS No.: 5945-50-6
Category:  

Plant Pyrolaceae Extract Iridoids Morinda officinalis How Extract Terpenoids Disease Research Fields Inflammation/Immunology Pyrola calliantha H. Andr. Extract Rubiaceae Extract

Target:  

Interleukin Related Keap1-Nrf2 Heme Oxygenase (HO) NF-κB Apoptosis

Monotropein is an iridoid glycoside that can be isolated from the roots of Morinda officinalis. Monotropein inhibits the expression of inflammatory mediators in dextran sulfate sodium (DSS)-induced colitis mouse model. Monotropein exerts protective effects against IL-1β-induced apoptosis and catabolic responses on osteoarthritis chondrocytes. Monotropein has cartilage protective activity. Monotropein can alleviate Cisplatin (HY-17394)-induced acute kidney injury by inhibiting oxidative damage, inflammation and apoptosis through activation of Nrf2/HO-1 pathway and inhibition of NF-κB signaling. Monotropein can be studied in research for osteoarthritis, acute kidney injury and acute lung injury [1] [2] .
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