1396 Results for "

Nuclear Counterstaining

" in MedChemExpress (MCE) Product Catalog:

Products (1396)

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223

Cyclosporin A

223 Publications Verification

Cat. No.: HY-B0579

CAS No.: 59865-13-3

Synonyms: Cyclosporine A; Ciclosporin A; CsA

Category:

Natural Products Microorganisms Anti-aging Disease Research Fields Inflammation/Immunology Cancer

Target:

Molecular Glues Complement System Antibiotic Cyclophilin

Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM . Cyclosporin A is a molecular glue, binds to cyclophilin and calcineurin, leading to inactivation of nuclear Factor of activated T Cells (NFAT) and a subsequent decrease in the immune response. Cyclosporin A also inhibits CD11a/CD18 adhesion .

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172

Propidium Iodide

172 Cited Publications

Cat. No.: HY-D0815

CAS No.: 25535-16-4

Propidium Iodide (PI) is a nuclear staining agent that stains DNA. Propidium Iodide is an analogue of ethidine bromide that emits red fluorescence upon embedding in double-stranded DNA. Propidium Iodide cannot pass through living cell membranes, but it can pass through damaged cell membranes to stain the nucleus. Propidium Iodide has a fluorescence wavelength of 493/617 nm and a wavelength of 536/635 nm after Mosaic with DNA. Propidium Iodide is commonly used in the detection of apoptosis (apoptosis) or necrosis (necrosis), and is often used in flow cytometry analysis.

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170

Hoechst 33342

170 Cited Publications

Cat. No.: HY-15559

CAS No.: 23491-52-3

Purity: 99.94%

Synonyms: bisBenzimide H 33342; HOE 33342

Hoechst 33342 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

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170

Hoechst 33342 trihydrochloride

170 Cited Publications

Cat. No.: HY-15559A

CAS No.: 875756-97-1

Purity: 99.81%

Synonyms: bisBenzimide H 33342 trihydrochloride; HOE 33342 trihydrochloride

Hoechst 33342 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

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165

JSH-23

165 Cited Publications

Cat. No.: HY-13982

CAS No.: 749886-87-1

Purity: 99.30%

Target:

NF-κB

Research Areas:

Metabolic Disease Inflammation/Immunology Cancer

JSH-23 is an NF-κB inhibitor which inhibits NF-κB transcriptional activity with an IC₅₀ of 7.1 μM in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. JSH-23 inhibits nuclear translocation of NF-κB p65 without affecting IκBα degradation .

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156

Retinoic acid

156 Cited Publications

Cat. No.: HY-14649

CAS No.: 302-79-4

Purity: 99.81%

Synonyms: Vitamin A acid; all-trans-Retinoic acid; ATRA

Category:

Ketones, Aldehydes, Acids Whitening Agent Cosmetic Research Endogenous metabolite Disease Research Fields Cancer

Target:

Organoid RAR/RXR PPAR Endogenous Metabolite Autophagy

Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with K_d of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.

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126

CH-223191

126 Cited Publications

Cat. No.: HY-12684

CAS No.: 301326-22-7

Purity: 99.96%

Target:

Aryl Hydrocarbon Receptor

Research Areas:

Cancer

CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor (AhR). CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC₅₀ of 0.03 μM .

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