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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
24 Results for "
OSBP
" in MedChemExpress (MCE) Product Catalog:
Products (24)
24 Results for "OSBP" in MCE Product Catalog:
24
Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .
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6 Cited Publications
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2 Cited Publications
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TTP-8307 is a potent inhibitor of the replication of several rhino- and enteroviruses. TTP-8307 inhibits coxsackievirus B3 (CVB3; EC50=1.2 μM) and poliovirus by interfering with the synthesis of viral RNA. TTP-8307 exerts antiviral activity through oxysterol-binding protein (OSBP) .
Cat. No.: HY-148391
CAS No.: 790224-37-2
Synonyms: SBF-1
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23-Oxa-OSW-1 (SBF-1), a derivative of OSW 1 (HY-101213), is a potent osterol-binding protein (OSBP) inhibitor. 23-Oxa-OSW-1 has antitumor activity .
Cat. No.: HY-17514S1
CAS No.: 1217512-35-0
Synonyms: R51211-d3
Cat. No.: HY-17514R
CAS No.: 84625-61-6
Synonyms: R51211 (Standard)
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Cat. No.: HY-178035
CAS No.: 2890760-73-1
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OSBP ligand-1 (Compound 2) is an Oxysterol-binding protein (OSBP) inhibitor. OSBP ligand-1 can be used for synthesis of PROTAC OSBP Degrader-1 (HY-178034) .
Cat. No.: HY-17514S2
CAS No.: 1309272-50-1
Synonyms: R51211-d9
Cat. No.: HY-178046
Research Areas:
OSBP ligand-Linker Conjugate 1 is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for OSBP (HY-178035) and a PROTAC linker, which recruits E3 ligases. OSBP ligand-Linker Conjugate 1 can be used for synthesis of PROTAC OSBP Degrader-1 (HY-178034) .
Cat. No.: HY-178034
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PROTAC OSBP Degrader-1 is a CRBN-dependent oxysterol-binding protein (OSBP) PROTAC degrader with a DC50 of 322 nM. PROTAC OSBP Degrader-1 exhibits high specificity for OSBP over other ORP family proteins. PROTAC OSBP Degrader-1 directly interacts with OSBP, possesses rapid cell-penetrating ability, and shows cytotoxicity against cancer cells. PROTAC OSBP Degrader-1 can be used in the research of glioblastoma, lung cancer, triple-negative breast cancer and cervical cancer .
Cat. No.: HY-RS09835
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OSBP Human Pre-designed siRNA Set A contains three designed siRNAs for OSBP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS26430
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Osbp Rat Pre-designed siRNA Set A contains three designed siRNAs for Osbp gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS09836
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OSBP2 Human Pre-designed siRNA Set A contains three designed siRNAs for OSBP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-163891
CAS No.: 2684411-12-7
Antifungal agent 107 (compound b24) is an OSBP inhibitor with antifungal activity. Antifungal agent 107 can be used to control cucumber downy mildew and potato late blight in greenhouse .
Cat. No.: HY-161798
Orpinolide is an OSBP and ORP4L inhibitor. Orpinolide disrupts Golgi homeostasis by inhibiting sterol and phosphatidylinositol phosphate countertransport at ER-Golgi membrane contact sites, while also inhibiting cholesterol biosynthesis, attenuating AKT signaling, and delaying anterograde protein transport, thereby inducing antiproliferative and cytotoxic activity in leukemia cells. Orpinolide can be used for research on leukemia .
Cat. No.: HY-RS19928
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Osbp Mouse Pre-designed siRNA Set A contains three designed siRNAs for Osbp gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
