138 Results for "

Orthopoxvirus

" in MedChemExpress (MCE) Product Catalog:
Products (138)

138 Results for "Orthopoxvirus" in MCE Product Catalog:

111
111 Publications Verification
Cat. No.: HY-13605
CAS No.: 147-94-4
Purity:  99.98%
Synonyms: Cytosine β-D-arabinofuranoside; Cytosine Arabinoside; Ara-C
Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine has antiviral effects against HSV. Cytarabine shows anti-orthopoxvirus activity.
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63
63 Cited Publications
Cat. No.: HY-B0434
CAS No.: 36791-04-5
Synonyms: Ribasphere
Research Areas:  

Infection Cancer

Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.
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51
51 Cited Publications
Cat. No.: HY-13502
CAS No.: 65271-80-9
Purity:  99.58%
Synonyms: Mitozantrone; NSC 301739
Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity . Mitoxantrone also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .
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51
51 Cited Publications
Cat. No.: HY-13502A
CAS No.: 70476-82-3
Purity:  99.55%
Synonyms: Mitozantrone dihydrochloride; NSC 301739 dihydrochloride
Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .
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50
50 Cited Publications
Cat. No.: HY-B0272
CAS No.: 13292-46-1
Synonyms: Rifampin; Rifamycin AMP
Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities. Rifampicin shows anti-orthopoxvirus activity.
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40
40 Cited Publications
Cat. No.: HY-B0330
CAS No.: 100986-85-4
Synonyms: (-)-Ofloxacin
Levofloxacin ((-)-Ofloxacin) is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin inhibits the DNA gyrase and topoisomerase IV. Levofloxacin can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin shows anti-orthopoxvirus activity .
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40
40 Cited Publications
Cat. No.: HY-B0330A
CAS No.: 138199-71-0
Synonyms: Levofloxacin hemihydrate
Levofloxacin hydrate (Levofloxacin hemihydrate) is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin hydrate inhibits the DNA gyrase and topoisomerase IV. Levofloxacin hydrate can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin hydrate shows anti-orthopoxvirus activity .
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40
40 Cited Publications
Cat. No.: HY-B0330B
CAS No.: 177325-13-2
Synonyms: (-)-Ofloxacin hydrochloride
Levofloxacin hydrochloride is an orally active antibiotic. Levofloxacin inhibits DNA gyrase and topoisomerase IV activity, inducing Apoptosis. Levofloxacin hydrochloride has antibacterial activity against both Gram-positive and Gram-negative bacteria. Levofloxacin hydrochloride exhibits anticancer activity against lung cancer. Levofloxacin hydrochloride has anti-acnegenic, anxiogenic, and analgesic effects. Levofloxacin hydrochloride shortens sleep duration in mice. Levofloxacin hydrochloride can be used in the research of infectious diseases (such as tuberculosis, chronic periodontitis, bacterial infections associated with stable COPD, and BK viremia) and lung cancer .
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38
38 Cited Publications
Cat. No.: HY-10442
CAS No.: 102052-95-9
Purity:  99.80%
Synonyms: DZNep; 3-Deazaneplanocin
3-Deazaneplanocin A (DZNep) is a potent histone methyltransferase EZH2 inhibitor . 3-Deazaneplanocin A is a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor. 3-Deazaneplanocin A shows anti-orthopoxvirus activity .
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38
38 Cited Publications
Cat. No.: HY-12186
CAS No.: 120964-45-6
Purity:  99.89%
Synonyms: DZNep hydrochloride; NSC 617989 hydrochloride; 3-Deazaneplanocin hydrochloride
3-Deazaneplanocin A hydrochloride (DZNep hydrochloride) is a potent histone methyltransferase EZH2 inhibitor . 3-Deazaneplanocin A hydrochlorideis a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor . 3-Deazaneplanocin A hydrochloride also has anti-orthopoxvirus and anti-variola activities .
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34
34 Cited Publications
Cat. No.: HY-B0313
CAS No.: 127-07-1
Synonyms: Hydroxycarbamide
Research Areas:  

Cancer

Hydroxyurea is a cell apoptosis inducer that inhibit DNA synthesis through inhibition of ribonucleotide reductase. Hydroxyurea shows anti-orthopoxvirus activity.
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30
30 Cited Publications
Cat. No.: HY-N7452
CAS No.: 4434-05-3
Coumermycin A1 is a JAK2 signal activator. Coumermycin A1 inhibits DNA Gyrase which thereby inhibits cell division in bacteria. Coumermycin A1 shows anti-orthopoxvirus activity.
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29
29 Cited Publications
Cat. No.: HY-N1150
CAS No.: 50-89-5
Synonyms: DThyd; NSC 21548
Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication .
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19
19 Cited Publications
Cat. No.: HY-B0502
CAS No.: 93106-60-6
Synonyms: BAY Vp 2674; PD160788
Research Areas:  

Infection

Enrofloxacin (BAY Vp 2674) is an effective antibiotic with an MIC90 of 0.312 μg/mL for Mycoplasma bovis.
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19
19 Cited Publications
Cat. No.: HY-B0502A
CAS No.: 93106-59-3
Synonyms: BAY Vp 2674 monohydrochloride; PD160788 monohydrochloride
Research Areas:  

Infection

Enrofloxacin monohydrochloride (BAY Vp 2674 monohydrochloride) is an effective antibiotic with an MIC90 of 0.312 μg/mL for Mycoplasma bovis. Enrofloxacin monohydrochloride shows inhibitory activity against vaccinia virus (VV).
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17
17 Cited Publications
Cat. No.: HY-N6733
CAS No.: 38966-21-1
Aphidicolin is an inhibitor of DNA polymerase α and δ, prevents mitotic cell division by interfering DNA polymerase activity. Aphidicolin is an antibiotic produced by mold Cephalosporium aphidicola, inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Aphidicolin exhibits anti-orthopoxvirus activity and potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line .
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17
17 Cited Publications
Cat. No.: HY-17438
CAS No.: 113852-37-2
Synonyms: GS 0504; HPMPC; (S)-HPMPC
Research Areas:  

Infection Cancer

Cidofovir (GS 0504) is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer . Cidofovir also has anti-orthopoxvirus and anti-variola activities .
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17
17 Cited Publications
Cat. No.: HY-17438A
CAS No.: 149394-66-1
Synonyms: GS 0504 dihydrate; HPMPC dihydrate; (S)-HPMPC dihydrate
Cidofovir (GS 0504; HPMPC; (S)-HPMPC) dihydrate is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir dihydrate inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir dihydrate induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer . Cidofovir dihydrate also has anti-orthopoxvirus and anti-variola activities .
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13
13 Cited Publications
Cat. No.: HY-B0307
CAS No.: 54-42-2
Synonyms: 5-Iodo-2′-deoxyuridine; 5-IUdR; IdUrd
Research Areas:  

Infection Cancer

Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC50 value of 4.3 μM . Idoxuridine shows anti-orthopoxvirus activity.
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13
13 Cited Publications
Cat. No.: HY-B0125
CAS No.: 82419-36-1
Synonyms: Hoe-280
Research Areas:  

Infection Cancer

Ofloxacin (Hoe-280) is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase. Ofloxacin shows inhibitory activity against vaccinia virus (VV).
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