86 Results for "

Osteoclastogenesis

" in MedChemExpress (MCE) Product Catalog:
Products (86)

86 Results for "Osteoclastogenesis" in MCE Product Catalog:

29
Omaveloxolone
Omaveloxolone
0 Images
29 Publications Verification
Cat. No.: HY-12212
CAS No.: 1474034-05-3
Purity:  99.38%
Synonyms: RTA 408
Target:  

Keap1-Nrf2 STING Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

Omaveloxolone (RTA 408) is an antioxidant inflammation modulator (AIM), which activates Nrf2 and suppresses nitric oxide (NO). Omaveloxolone attenuates osteoclastogenesis by inhibiting STING dependent NF-κb signaling.
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8
Sappanone A
Sappanone A
0 Images
8 Cited Publications
Cat. No.: HY-113556
CAS No.: 102067-84-5
Purity:  99.87%
Category:  

Leguminosae/Fabaceae Extract Plant Flavonoids Caesalpinia sappan L. Extract Disease Research Fields Inflammation/Immunology Isoflavones

Target:  

Phosphodiesterase (PDE) NF-κB Keap1-Nrf2 Reactive Oxygen Species (ROS) TNF Receptor Nuclear Factor of activated T Cells (NFAT) Akt ERK p38 MAPK NO Synthase Interleukin Related COX JNK

Sappanone A is an orally active homoisoflavone found in sappan L. Sappanone A is a PDE4 and NF-κB inhibitor with anti-inflammatory and antioxidant effect. Sappanone A induces HO-1 expression through activation of Nrf2 pathway. Sappanone A also inhibits RANKL-induced osteoclastogenesis. Sappanone A has great potential in the research of inflammation-related and cardiovascular .
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6
Isobavachin
Isobavachin
0 Images
6 Cited Publications
Cat. No.: HY-N0762
CAS No.: 31524-62-6
Category:  

Leguminosae/Fabaceae Extract Plant Flavonoids Neurological Disease Flavonones Psoralea corylifolia L. Extract Phenols Polyphenols Disease Research Fields

Target:  

Cytochrome P450 UGT p38 MAPK NF-κB NO Synthase COX Fc Receptor (FcR) RANKL/RANK Keap1-Nrf2 Reactive Oxygen Species (ROS) Apoptosis Autophagy

Isobavachin is an orally active, blood-brain barrier-penetrating prenylated flavonoid present in Psoralea corylifolia. Isobavachin inhibits human CYP2B6, CYP2C9, CYP2C19, UGT1A1, UGT1A9, and UGT2B7. Isobavachin suppresses MAPK activation, NF-κB nuclear translocation, overexpression of iNOS/COX-2, FcεRI-mediated signaling pathways, and RANKL-induced osteoclastogenesis. Isobavachin induces autophagy, cytotoxicity, neuronal differentiation, and NRF2 activation; it alleviates oxidative damage, inflammatory responses, apoptosis, iron accumulation, mitochondrial biogenesis, and mast cell degranulation. Isobavachin is applicable to research related to liver injury, inflammatory diseases, osteoporosis, liver cancer, prostate cancer, glioma, periodontitis-induced bone loss, and Alzheimer's disease .
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4
Epimedin A
Epimedin A
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4 Cited Publications
Cat. No.: HY-N0257
CAS No.: 110623-72-8
Category:  

Flavonols Plant Flavonoids Monophenols Epimedium brevicornu Maxim. Extract Other Diseases Phenols Disease Research Fields Berberidaceae Extract

Target:  

PI3K Akt NF-κB NOD-like Receptor (NLR) Keap1-Nrf2 Heme Oxygenase (HO) SOD Caspase Interleukin Related

Epimedin A, one of the main flavonoid active components in Herba Epimedii, is orally active. Epimedin A can inhibit osteoclastogenesis, differentiation, and bone resorption. Epimedin A also possesses anti-inflammatory activity. Epimedin A can be used in the research of osteoporosis and inflammatory diseases .
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4
Sciadopitysin
Sciadopitysin
0 Images
4 Cited Publications
Cat. No.: HY-N2119
CAS No.: 521-34-6
Category:  

Plant Flavonoids Ginkgoaceae Extract Phenols Polyphenols Disease Research Fields Inflammation/Immunology Biflavones Ginkgo biloba L. Extract

Target:  

TNF Receptor NF-κB

Sciadopitysin is a type of biflavonoids in leaves from ginkgo biloba . Sciadopitysi inhibits RANKL-induced osteoclastogenesis and bone loss by inhibiting NF-κB activation and reducing the expression of c-Fos and NFATc1 .
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2
Vaccarin
Vaccarin
0 Images
2 Cited Publications
Cat. No.: HY-N1419
CAS No.: 53452-16-7
Category:  

Plant Flavonoids Flavones Metabolic Disease Phenols Polyphenols Other Families Extract Disease Research Fields

Target:  

AMPK Akt ERK p38 MAPK NF-κB Nuclear Factor of activated T Cells (NFAT) JNK

Vaccarin is an orally active flavonoid glycoside with multiple biological functions. Vaccarin promotes neovascularization by activating AKT and ERK. Vaccarin activates the AMPK signaling pathway to improve insulin resistance and steatosis. Vaccarin is a MAPK, NF-κB, and NFAT inhibitor, effectively blocking RANKL-induced osteoclastogenesis .
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2
Methylnissolin
Methylnissolin
0 Images
2 Cited Publications
Cat. No.: HY-N2484
CAS No.: 73340-41-7
Synonyms: Astrapterocarpan
Category:  

Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Extract Cardiovascular Disease Leguminosae/Fabaceae Extract Plant Flavonoids Monophenols Phenols Disease Research Fields Other Flavonoids

Target:  

PDGFR ERK

Methylnissolin (Astrapterocarpan) is an osteoclast inhibitor with anti-inflammatory, neuroprotective and antioxidant activities. Methylnissolin downregulates the activation of the MAPK and PI3K/AKT pathways, inhibits the phosphorylation of MAPK1 and AKT1, and blocks PDGF-BB-induced phosphorylation of ERK1/2. Methylnissolin reduces the expression and secretion of proinflammatory mediators, decreases intracellular ROS levels, upregulates antioxidant enzymes, and downregulates osteoclastogenesis markers. Methylnissolin is applicable to research related to ischemic stroke, osteoporosis, cardiovascular diseases, skin aging, etc.
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2
TNFRSF11B/OPG Protein, Human (HEK293, His)
TNFRSF11B/OPG Protein, Human (HEK293, His)
0 Images
2 Cited Publications
Cat. No.: HY-P70805
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF11B; Osteoprotegerin; Prev. OPG; Tumor Necrosis Factor Receptor Superfamily, Member 11b; OCIF; Tumor Necrosis Factor Receptor Superfamily Member 11B; Osteoclastogenesis Inhibitory Factor; PDB5; TNF Receptor Superfamily Member 11b; TR1
Species:  
Human
Source:  
HEK293
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2
TNFRSF11B/OPG Protein, Mouse (HEK293, His)
TNFRSF11B/OPG Protein, Mouse (HEK293, His)
0 Images
2 Cited Publications
Cat. No.: HY-P71017
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF11B; Osteoprotegerin; Prev. OPG; Tumor Necrosis Factor Receptor Superfamily, Member 11b; OCIF; Tumor Necrosis Factor Receptor Superfamily Member 11B; Osteoclastogenesis Inhibitory Factor; PDB5; TNF Receptor Superfamily Member 11b; TR1
Species:  
Mouse
Source:  
HEK293
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1
Rhoifolin
Rhoifolin
0 Images
1 Cited Publications
Cat. No.: HY-N0755
CAS No.: 17306-46-6
Category:  

Plant Flavonoids Anacardiaceae Extract Rhus succedanea Extract Flavones Disease Research Fields Endocrinology Cancer

Target:  

Insulin Receptor GLUT NF-κB p38 MAPK Autophagy

Rhoifolin is a flavone glycoside can be isolated from Rhus succedanea. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines .
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1
Roburic acid
Roburic acid
0 Images
1 Cited Publications
Cat. No.: HY-N0481
CAS No.: 6812-81-3
Category:  

Triterpenes Plant Gentiana macrophylla Pall. Extract Terpenoids Gentianaceae Extract Disease Research Fields Inflammation/Immunology

Target:  

COX TNF Receptor NO Synthase Interleukin Related NF-κB Apoptosis p38 MAPK JNK ERK Keap1-Nrf2 RANKL/RANK

Roburic acid acts as an anti-inflammatory, anti-tumor and osteoclastogenesis inhibitor, with a Ki of 7.066 μM against human TNF, an IC50 of 9 μM against human COX-2, and an IC50 of 5 μM against ovine COX-1. Roburic acid reduces the production of inflammatory mediators such as NO and IL-6 in macrophages by inhibiting the NF-κB and MAPK (p38/JNK) pathways. By competitively inhibiting the TNF-TNF-R1 interaction, Roburic acid blocks the downstream NF-κB signaling pathway, thereby inducing cell cycle arrest and apoptosis in cancer cells. Roburic acid specifically inhibits osteoclastogenesis and bone resorption by suppressing the RANKL/TRAF6/NF-κB/NFATc1 axis. Roburic acid can be used in research related to osteolytic diseases such as osteoporosis, colorectal cancer and inflammatory diseases .
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1
Neomangiferin
Neomangiferin
0 Images
1 Cited Publications
Cat. No.: HY-N0723
CAS No.: 64809-67-2
Category:  

Plant Xanthones Metabolic Disease Phenols Polyphenols Liliaceae Extract Anemarrhena asphodeloides Bunge Extract Disease Research Fields

Target:  

Autophagy p38 MAPK TNF Receptor Interleukin Related PPAR

Neomangiferin is an orally active natural flavonoid. Neomangiferin partially ameliorates non-alcoholic fatty liver disease (NAFLD) by regulating the expression of genes related to free fatty acid uptake and lipid oxidation. Neomangiferin exerts anti-colitis effects by inhibiting Th17/Treg cell differentiation. Neomangiferin exerts anti-aging and lifespan-extending effects by targeting upregulation of bas-1, which in turn activates the autophagy, IIS and MAPK pathways. Neomangiferin has the potential to prevent aseptic loosening of prostheses after total joint arthroplasty due to its significant anti-inflammatory and osteoclastogenesis-inhibiting effects .
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1
Pteryxin
Pteryxin
0 Images
1 Cited Publications
Cat. No.: HY-N2157
CAS No.: 13161-75-6
Synonyms: (+)-Pteryxin
Category:  

Umbelliferae/Apiaceae Extract Plant Apium graveolens Linn. Extract Coumarins Phenylpropanoids

Target:  

Cholinesterase (ChE) NF-κB NOD-like Receptor (NLR) Keap1-Nrf2 Reactive Oxygen Species (ROS) Nuclear Factor of activated T Cells (NFAT) p38 MAPK

Pteryxin ((+)-Pteryxin) is an orally active multi-target inhibitor that targets NF-κB, MAPK, NLRP3 inflammasome, and Nrf2/ARE pathways. Pteryxin is also a BChE inhibitor (IC50=12.96 μg/mL) with a low inhibitory efficiency on AChE. Pteryxin inhibits the Ca 2+-calcineurin-NFATc1 pathway by blocking NF-κB/MAPK signaling, inhibiting NLRP3 inflammasome activation, and reducing ROS generation, and activates Nrf2-mediated antioxidant enzyme expression. Pteryxin has anti-inflammatory, antioxidant, and osteoclastogenesis inhibitory activities. Pteryxin can be used in the study of inflammatory diseases, osteoporosis, diabetes, and Alzheimer's disease .
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1
Orcinol glucoside
Orcinol glucoside
0 Images
1 Cited Publications
Cat. No.: HY-N0008
CAS No.: 21082-33-7
Category:  

Plant Monophenols Amaryllidaceae Extract Phenols Hypoxidaceae Extract Curculigo orchioides Gaertn. Extract

Target:  

Wnt p38 MAPK mTOR Keap1-Nrf2 TGF-β Receptor

Orcinol glucoside is an orally active, blood-brain barrier permeable osteoblast proliferation promoter that targets the Nrf2/Keap1, mTOR and p38 signaling pathways. Orcinol glucoside promotes Nrf2 nuclear translocation, upregulates antioxidant enzyme levels, enhances the phosphorylation of mTOR and p70S6K, and inhibits the enzymatic activity of HAS2 as well as the nuclear translocation of GR. Orcinol glucoside also alleviates oxidative stress, inhibits autophagic flux, osteoclastogenesis and TGF-β1-induced M2 polarization, while reducing collagen deposition and effectively promoting the proliferation, differentiation and mineralization of osteoblasts. Orcinol glucoside also exhibits anti-pulmonary fibrosis, anxiolytic and antidepressant activities. Orcinol glucoside can be used in the research of senile and glucocorticoid-induced osteoporosis, idiopathic pulmonary fibrosis (IPF), anxiety and other related diseases .
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1
Ganoderic acid DM
Ganoderic acid DM
0 Images
1 Cited Publications
Cat. No.: HY-120140
CAS No.: 173075-45-1
Purity:  99.65%
Category:  

Triterpenes Plant Terpenoids Metabolic Disease Polyporaceae Extract Disease Research Fields Inflammation/Immunology

Target:  

Apoptosis PI3K

Ganoderic acid DM, a natural triterpenoid isolated from Ganoderma lucidum, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Ganoderic acid DM as a specific inhibitor of osteoclastogenesis .
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1
Rubiadin-1-methyl ether
Rubiadin-1-methyl ether
0 Images
1 Cited Publications
Cat. No.: HY-N1956
CAS No.: 7460-43-7
Category:  

Quinones Plant Monophenols Anthraquinones Rubia cordifolia L. Extract Metabolic Disease Phenols Disease Research Fields Rubiaceae Extract

Target:  

NF-κB RANKL/RANK Autophagy TGF-β Receptor

Rubiadin-1-methyl ether is an orally potent NF-κB p65 inhibitor and autophagy inhibitor. Rubiadin-1-methyl ether inhibits RANKL-induced phosphorylation and nuclear translocation of p65, suppresses BECN1 transcription, blocks LC3 conversion and autophagosome formation, thereby reducing the levels of BECN1 mRNA and Beclin1 protein. Rubiadin-1-methyl ether inhibits osteoclastogenesis, cell proliferation, macrophage M2 polarization and the TGF-β1 signaling pathway, and effectively alleviates pulmonary inflammation. Rubiadin-1-methyl ether is widely used in research on osteoporosis, pulmonary fibrosis, idiopathic pulmonary fibrosis, acute lung injury and other related diseases .
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1
TNFRSF11B/OPG Protein, Human (CHO, Fc)
TNFRSF11B/OPG Protein, Human (CHO, Fc)
0 Images
1 Cited Publications
Cat. No.: HY-P7053
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF11B; Osteoprotegerin; Prev. OPG; Tumor Necrosis Factor Receptor Superfamily, Member 11b; OCIF; Tumor Necrosis Factor Receptor Superfamily Member 11B; Osteoclastogenesis Inhibitory Factor; PDB5; TNF Receptor Superfamily Member 11b; TR1
Species:  
Human
Source:  
CHO
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1
TNFRSF11B/OPG Protein, Human (HEK293, hFc-Flag)
TNFRSF11B/OPG Protein, Human (HEK293, hFc-Flag)
0 Images
1 Cited Publications
Cat. No.: HY-P700432
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF11B; Osteoprotegerin; Prev. OPG; Tumor Necrosis Factor Receptor Superfamily, Member 11b; OCIF; Tumor Necrosis Factor Receptor Superfamily Member 11B; Osteoclastogenesis Inhibitory Factor; PDB5; TNF Receptor Superfamily Member 11b; TR1
Species:  
Human
Source:  
HEK293
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Schizophyllan
Schizophyllan
0 Images
Cat. No.: HY-165126
CAS No.: 9050-67-3
Synonyms: SPG
Target:  

C-type Lectin-like Receptors (CTLRs) Endogenous Metabolite Sirtuin JNK p38 MAPK PPAR AP-1

Research Areas:  

Infection Metabolic Disease Inflammation/Immunology Cancer

Schizophyllan (SPG) is an orally active extracellular β-glucan produced by the fungus Schizophyllum commune. Schizophyllan improves mitochondrial function and protects against metabolic liver injury by activating the SIRT3 pathway. Schizophyllan inhibits osteoclastogenesis and promotes osteoblast differentiation by suppressing the phosphorylation of JNK/p38, as well as downregulating PGC1β/PPARγ, c-Fos and NFATc1. Recognized via Dectin-1, schizophyllan enables precise delivery of oligonucleotide drugs and antigens to antigen-presenting cells, thus holding great potential in the treatment of inflammatory diseases and vaccine development .
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Rosavin
Rosavin
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Cat. No.: HY-N0507
CAS No.: 84954-92-7
Category:  

Rhodiola rosea Linn. Extract Plant Simple Phenylpropanols Crassulaceae Extract Phenylpropanoids

Target:  

TNF Receptor Interleukin Related

Rosavin, an orally bioactive phenylpropanoid from Rhodiola rosea L. (RRL), is an adaptogen that enhances the body’s response to environmental stress. Rosavin significantly influences bone tissue metabolism by inhibiting osteoclastogenesis and promoting osteoblast differentiation, also impacts various diseases, demonstrating antidepressant, adaptogenic, and anxiolytic effects in mouse models. Additionally, Rosavin improves survival, reducing intestinal damage in irradiated rats and Ischemia-reperfusion(I/R)-induced cerebral injury in vivo by regulating inflammation and oxidative stress, making it a promising candidate for research in radiation-induced intestinal injury, I/R-induced cerebral injury and osteoporosis .
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