1 Result for "

Osthenol

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Osthenol" in MCE Product Catalog:

Osthenol
Osthenol
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Cat. No.: HY-N2554
CAS No.: 484-14-0
Synonyms: Ostenol
Category:  

Umbelliferae/Apiaceae Extract Plant Notopterygium incisum Ting ex H. T. Chang Extract Coumarins Phenols Polyphenols Phenylpropanoids

Target:  

Monoamine Oxidase PI3K Akt Apoptosis

Osthenol (Ostenol) is a reversible, selective, competitive inhibitor of hMAO-A (IC50=0.74 μM, Ki=0.26 μM), with antifungal and antibacterial activity. Osthenol inhibits the oxidative deamination of hMAO-A and regulates the metabolism of monoamine neurotransmitters. Osthenol also inhibits the PI3K/AKT signaling pathway to induce apoptosis of colon cancer cells, arrest the cell cycle at the G1 phase, and inhibit cell proliferation. Osthenol is mainly used in the study of neurological diseases and cancer, especially depression-related MAO-A targeted intervention and colon cancer .
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