3751 Results for "

Oxidative

" in MedChemExpress (MCE) Product Catalog:

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935

Erastin

935 Publications Verification

Cat. No.: HY-15763

CAS No.: 571203-78-6

Purity: 99.62%

Target:

VDAC Ferroptosis Disulfidptosis

Research Areas:

Cancer

Erastin is a ferroptosis inducer. Erastin exhibits the mechanism of ferroptosis induction related to ROS and iron-dependent signaling. Erastin inhibits voltage-dependent anion channels (VDAC2/VDAC3) and accelerates oxidation, leading to the accumulation of endogenous reactive oxygen species. Erastin also disrupts mitochondrial permeability transition pore (mPTP) with anti-tumor activity. Furthermore, Erastin can block the uptake of cystine mediated by SLC7A11 and also spares UMRC6-EV and -C91A cells from disulfidptosis under glucose starvation .

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881

Z-VAD-FMK

881 Cited Publications

Cat. No.: HY-16658B

CAS No.: 161401-82-7

Synonyms: Z-VAD(OH)-FMK

Target:

Caspase Apoptosis RIP kinase Glutathione Peroxidase Reactive Oxygen Species (ROS)

Research Areas:

Inflammation/Immunology Cancer

Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

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353

MitoSOX Red

353 Cited Publications

Cat. No.: HY-D1055

CAS No.: 1003197-00-9

MitoSOX Red is a live cell fluorescent probe that specifically targets mitochondria and is cell membrane permeable. MitoSOX Red enters mitochondria and is oxidized by superoxide but not by other ROS or RNS generating systems. The oxidized MitoSOX Red then binds to nucleic acids in mitochondria/nucleus, producing strong red fluorescence. MitoSOX Red can be used as a fluorescent indicator to specifically detect superoxide. In addition, superoxide dismutase (SOD) can prevent the oxidation of MitoSOX Red.
Excitation/emission wavelength: 510/580 nm.

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223

Metformin hydrochloride

223 Cited Publications

Cat. No.: HY-17471A

CAS No.: 1115-70-4

Synonyms: 1,1-Dimethylbiguanide hydrochloride

Target:

AMPK Autophagy Mitophagy Apoptosis mTOR

Research Areas:

Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Metformin (1,1-Dimethylbiguanide) hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .

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223

Metformin

223 Cited Publications

Cat. No.: HY-B0627

CAS No.: 657-24-9

Synonyms: 1,1-Dimethylbiguanide

Target:

AMPK Autophagy Mitophagy Apoptosis mTOR

Research Areas:

Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Metformin (1,1-Dimethylbiguanide) inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .

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203

CCCP

203 Cited Publications

Cat. No.: HY-100941

CAS No.: 555-60-2

Purity: 98.83%

Synonyms: Carbonyl cyanide 3-chlorophenylhydrazone; Carbonyl Cyanide m-Chlorophenylhydrazone

Target:

Oxidative Phosphorylation PINK1/Parkin STING IFNAR Mitochondrial Metabolism Bacterial Apoptosis

Research Areas:

Infection Neurological Disease Cancer

CCCP is an oxidative phosphorylation (OXPHOS) uncoupler. CCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation .

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179

Clozapine N-oxide

179 Cited Publications

Cat. No.: HY-17366

CAS No.: 34233-69-7

Target:

Drug Metabolite mAChR Dopamine Receptor

Research Areas:

Neurological Disease

Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide can't cross the blood-brain barrier . Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC₅₀=11 nM) agonist .

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179

Clozapine N-oxide dihydrochloride

179 Cited Publications

Cat. No.: HY-17366A

CAS No.: 2250025-93-3

Target:

mAChR Dopamine Receptor Drug Metabolite

Research Areas:

Neurological Disease

Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride cannot cross the blood-brain barrier . Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC₅₀=11 nM) agonist .

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168

Mitoquinone mesylate

168 Cited Publications

Cat. No.: HY-100116A

CAS No.: 845959-50-4

Purity: 99.09%

Synonyms: MitoQ mesylate; MitoQ10 mesylate

Target:

Reactive Oxygen Species (ROS)

Research Areas:

Metabolic Disease Cancer

Mitoquinone mesylate is a TPP-based, mitochondrially targeted antioxidant in order to protect against oxidative damage .

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154

Etomoxir

154 Cited Publications

Cat. No.: HY-50202

CAS No.: 124083-20-1

Synonyms: (R)-(+)-Etomoxir

Target:

Carnitine Palmitoyltransferase (CPT) Apoptosis

Research Areas:

Metabolic Disease Cancer

Etomoxir ((R)-(+)-Etomoxir) is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.

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154

Etomoxir sodium salt

154 Cited Publications

Cat. No.: HY-50202A

CAS No.: 828934-41-4

Synonyms: (R)-(+)-Etomoxir sodium salt

Target:

Carnitine Palmitoyltransferase (CPT) Apoptosis

Research Areas:

Metabolic Disease Cancer

Etomoxir((R)-(+)-Etomoxir) sodium salt is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig .

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134

Elesclomol

134 Cited Publications

Cat. No.: HY-12040

CAS No.: 488832-69-5

Purity: 99.80%

Synonyms: STA-4783

Target:

Reactive Oxygen Species (ROS) Apoptosis Cuproptosis

Research Areas:

Cancer

Elesclomol (STA-4783) is a potent copper ionophore and promotes copper-dependent cell death (cuproptosis). Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand. Elesclomol inhibits FDX1-mediated Fe-S cluster biosynthesis. Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research .

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130

FCCP

130 Cited Publications

Cat. No.: HY-100410

CAS No.: 370-86-5

Purity: 99.23%

Synonyms: Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone

Target:

Oxidative Phosphorylation PINK1/Parkin Mitochondrial Metabolism

Research Areas:

Cancer

FCCP is an uncoupler of oxidative phosphorylation (OXPHOS) in mitochondria. FCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation .

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127

Oligomycin

127 Cited Publications

Cat. No.: HY-N6782

CAS No.: 1404-19-9

Category:

Infection Microorganisms Macrolide Antibiotics Antifungal Antibiotics Disease Research Anticancer Disease Research Fields

Target:

Oxidative Phosphorylation ATP Synthase Fungal Antibiotic

Oligomycin, an antifungal antibiotic, is an inhibitor of H ⁺-ATP-synthase. Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells .

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