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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
P1D-34
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "P1D-34" in MCE Product Catalog:
Cat. No.: HY-171334A
Research Areas:
P1D-34 is a potent PIN1 PROTAC degrader with a DC50 of 177 nM. P1D-34 induces PIN1 degradation in a proteasome- and ubiquitination-like modification-dependent manner, thereby increasing intracellular ROS levels, downregulating the unfolded protein response pathway, and inducing DNA damage, cell cycle arrest and apoptosis. P1D-34 can be used in studies related to acute myeloid leukemia .
Cat. No.: HY-171334
CAS No.: 2957895-04-2
Research Areas:
(Rac)-P1D-34 is a Pin1 PROTAC degrader that recruits cereblon, with a DC50 of 177 nM. (Rac)-P1D-34 induces Pin1 degradation via proteasome- and ubiquitin-like modification-dependent pathways. (Rac)-P1D-34 upregulates ROS and DNA damage, downregulates the UPR pathway, and inhibits leukemia cell proliferation; it also sensitizes drug-resistant acute myeloid leukemia cells to Venetoclax (ABT-199) (HY-15531) by downregulating Mcl-1 levels. (Rac)-P1D-34 can be used in the research of acute myeloid leukemia .
Cat. No.: HY-171442A
Research Areas:
(R)-PIN1 ligand-2 is a PIN1 ligand, and can be used for synthesis of PROTACs, such as P1D-34 (HY-171334A) .
Cat. No.: HY-171442
CAS No.: 2957895-02-0
Research Areas:
PIN1 ligand-2 (Intermediate M6) is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). PIN1 ligand-2 can be used for synthesizing PROTACT (Rac)-P1D-34 (HY-171334) .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
