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44 Results for "

PAI 1

" in MedChemExpress (MCE) Product Catalog:

Products (44)

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PAI-1

Cat. No.: HY-P11413

CAS No.: 139446-70-1

Target:

PAI-1 Serpin Ser/Thr Protease Furin Toll-like Receptor (TLR) LDLR Integrin Apoptosis

Research Areas:

Cardiovascular Disease Metabolic Disease Inflammation/Immunology

PAI-1 is a serine protease inhibitor (SERPIN). PAI-1 binds to and irreversibly inhibits uPA, tPA and furin; it also interacts with vitronectin, α1-acid glycoprotein, CRT, TLR4, proteasome α-3 subunit, uPAR, LRP1, Integrin αvβ3 and thrombin. PAI-1 regulates fibrinolysis, extracellular matrix turnover, cell migration, angiogenesis, inflammatory response and tissue remodeling; it mediates epithelial-mesenchymal transition (EMT)/endothelial-mesenchymal transition (EndMT), apoptosis and thrombus stabilization. PAI-1 can be used in research related to sepsis, acute lung injury, cardiovascular diseases, tissue fibrosis, diabetic nephropathy, obstructive nephropathy and non-insulin-dependent diabetes mellitus .

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Tiplaxtinin

18 Publications Verification

Cat. No.: HY-15253

CAS No.: 393105-53-8

Purity: 99.03%

Synonyms: PAI-039; Tiplasinin

Target:

PAI-1 Apoptosis

Research Areas:

Metabolic Disease Cancer

Tiplaxtinin is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC₅₀ of 2.7 μM .

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TM5441

10 Cited Publications

Cat. No.: HY-101761

CAS No.: 1190221-43-2

Purity: 99.08%

Target:

PAI-1 Apoptosis

Research Areas:

Cardiovascular Disease Cancer

TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1), has IC₅₀ values between 13.9 and 51.1 μM and induces intrinsic apoptosis in several human cancer cell lines. TM5441 attenuates Nω-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence .

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