54

C75

54 Publications Verification

Cat. No.: HY-12364

CAS No.: 218137-86-1

Purity: 99.91%

Target:

Carnitine Palmitoyltransferase (CPT) Fatty Acid Synthase (FASN)

Research Areas:

Cancer

C75 is a synthetic fatty-acid synthase (FASN) inhibitor; inhibits prostate cancer cells PC3 with an IC₅₀ of 35 μM . C75 is a potent CPT1A activator .

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6

SMI-16a

6 Cited Publications

Cat. No.: HY-101947

CAS No.: 587852-28-6

Purity: ≥98.0%

Synonyms: PIM1/2 Kinase Inhibitor VI

Target:

Pim

Research Areas:

Cancer

SMI-16a is a selective Pim kinase inhibitor with IC₅₀ values of 0.15, 0.02 and 48 μM for Pim1, Pim2 and PC3 cells, respectively.

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5

GSK-2881078

5 Cited Publications

Cat. No.: HY-100186

CAS No.: 1539314-06-1

Purity: 99.74%

Target:

Androgen Receptor

Research Areas:

Cardiovascular Disease Others Metabolic Disease Inflammation/Immunology Endocrinology Cancer

GSK-2881078 is an orally active and nonsteroidal selective androgen receptor modulator (SARM) which act as partial AR agonists in androgenic tissues while mainly as complete AR agonists in synthetic metabolic tissues,induces AR-mediated transcriptional activation in PC3(AR)₂ cells (EC₅₀ = 3.99 nM) and the effect can be inhibited by the non-steroidal AR antagonist Bicalutamide. GSK-2881078 can be used in research of muscle weakness and cachexia associated with both chronic and acute illness .

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3

AMG-337

3 Cited Publications

Cat. No.: HY-18696

CAS No.: 1173699-31-4

Target:

c-Met/HGFR Caspase Apoptosis

Research Areas:

Cancer

AMG-337 is a potent, orally active, selective MET kinase inhibitor with IC₅₀ values of 1, 1, 4.7, 5, 21.5, 1077 and >4000 nM of WT MET, H1094R MET, M1250T MET, HGF-stimulated pMET (PC3 cells) MET, V1092I MET, Y1230H MET, and D1228H MET, respectively. AMG 337 inhibits the phosphorylation of MET and downstream effectors in MET-amplified cancer cell lines, resulting in an inhibition of MET-dependent cell proliferation and induction of apoptosis .

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2

CCG-203971

2 Cited Publications

Cat. No.: HY-108361

CAS No.: 1443437-74-8

Purity: 99.89%

Target:

Ras

Research Areas:

Inflammation/Immunology Cancer

CCG-203971 is a second-generation Rho/MRTF/SRF pathway inhibitor. CCG-203971 potently targets RhoA/C-activated SRE-luciferase (IC₅₀ =6.4 μM). CCG-203971 inhibits PC-3 cell migration with an IC₅₀ of 4.2 μM. Potential anti-metastasis Agent .

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1

Cysmethynil

1 Cited Publications

Cat. No.: HY-16160

CAS No.: 851636-83-4

Target:

Autophagy ICMT

Research Areas:

Neurological Disease Cancer

Cysmethynil is an Icmt inhibitor(IC₅₀ = 2.4 μM). Cysmethynil inhibites RAS membrane binding and EGF signal transduction. Cysmethynil prevents the cells in the G1 phase and induces autophagy. Cysmethynil inhibits PC3 cells proliferation, has synergistic effect with Paclitaxel (HY-B0015) and Doxorubicin (HY-15142A). Cysmethynil has anti-tumor effects and can be used for solid tumor (such as prostate cancer et al.) research .

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1

Cathepsin X-IN-1

1 Cited Publications

Cat. No.: HY-146985

CAS No.: 2418577-51-0

Purity: 99.62%

Target:

Cathepsin

Research Areas:

Neurological Disease Cancer

Cathepsin X-IN-1 (compound 25) is a potent Cathepsin X inhibitor with an IC₅₀ of 7.13 µM. Cathepsin X-IN-1 decreases PC-3 cell migration with low cytotoxic .

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1

CBP/p300-IN-12

1 Cited Publications

Cat. No.: HY-132197

CAS No.: 2738688-57-6

Purity: 99.72%

Target:

Epigenetic Reader Domain Histone Acetyltransferase

Research Areas:

Cancer

CBP/p300-IN-12 is a potent and selective covalent histone acetyltransferases p300 (IC₅₀ of 166 nM) and CBP inhibitor. CBP/p300-IN-12 decreases the levels of H3K27Ac of PC-3 cells (EC₅₀ of 37 nM). CBP/p300-IN-12 forms a covalent adduct with C1450 .

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1

19-Hydroxybufalin

1 Cited Publications

Cat. No.: HY-N7019

CAS No.: 39844-86-5

Category:

Animals Disease Research Fields Cancer Steroids

Target:

Others

19-Hydroxybufalin is a bufadienolide, inhibits epithelial-mesenchymal transition and attenuates the migration and invasion of PC3 cells .

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1

ABT-100

1 Cited Publications

Cat. No.: HY-119257

CAS No.: 450839-40-4

Purity: 98.18%

Target:

Farnesyl Transferase Apoptosis

Research Areas:

Cancer

ABT-100, a chemical probe, is a potent, highly selective and orally active farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation (IC₅₀s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity .

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AGPS-IN-1

Cat. No.: HY-153910

CAS No.: 2316782-88-2

Purity: 99.74%

Target:

Others

Research Areas:

Cancer

AGPS-IN-1 (Compound 2i) is an effective AGPS binder. AGPS-IN-1 reduces ether lipids levels and cell migration rate. AGPS-IN-1 inhibits epithelial-mesenchymal transition (EMT) in prostate PC-3 and breast MDA-MB-231 cancer cells .

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PROTAC CDK2/9 Degrader-1

Cat. No.: HY-130709

CAS No.: 2408641-24-5

Purity: 99.85%

Target:

PROTACs CDK

Research Areas:

Cancer

PROTAC CDK2/9 Degrader-1 (Compound F3) is a potent dual degrader for CDK2 (DC₅₀=62 nM) and CDK9 (DC₅₀=33 nM). PROTAC CDK2/9 Degrader-1 suppresses prostate cancer PC-3 cell proliferation (IC₅₀=0.12 µM) by effectively blocking the cell cycle in S and G2/M phases. PROTAC CDK2/9 Degrader-1 is a PROTAC by tethering CDK inhibitor with Cereblon ligand .

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