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21 Results for "

PC-3 cell lines

" in MedChemExpress (MCE) Product Catalog:

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AMG-337

3 Cited Publications

Cat. No.: HY-18696

CAS No.: 1173699-31-4

Target:

c-Met/HGFR Caspase Apoptosis

Research Areas:

Cancer

AMG-337 is a potent, orally active, selective MET kinase inhibitor with IC₅₀ values of 1, 1, 4.7, 5, 21.5, 1077 and >4000 nM of WT MET, H1094R MET, M1250T MET, HGF-stimulated pMET (PC3 cells) MET, V1092I MET, Y1230H MET, and D1228H MET, respectively. AMG 337 inhibits the phosphorylation of MET and downstream effectors in MET-amplified cancer cell lines, resulting in an inhibition of MET-dependent cell proliferation and induction of apoptosis .

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August 31

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Telomerase-IN-8

Cat. No.: HY-204056

CAS No.: 1884341-01-8

Target:

Telomerase

Research Areas:

Cancer

Telomerase-IN-8 is an orally active telomerase inhibitor, with an IC₅₀ value of 0.98 μM. Telomerase-IN-8 exhibits potent antiproliferative activity against multiple tumor cell lines, including PC3, Bcap-37, MGC-803 and HepG2. Telomerase-IN-8 demonstrates potent antitumor efficacy in S180 sarcoma or HepG2 hepatoma xenograft mice. Telomerase-IN-8 can be used for the study of telomerase-targeted anticancer .

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