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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1 Result for "
PF06671008
" in MedChemExpress (MCE) Product Catalog:
Products (1)
1 Results for "PF06671008" in MCE Product Catalog:
Cat. No.: HY-P992551
PF-06671008 is a bispecific CD3/P-cadherin binding agent (Kd 11.4, 0.47 nM). PF-06671008 binds to the T cell receptor complex, activates polyclonal T cells, and forms a trimolecular complex that redirects T cells to P-cadherin-expressing tumor cells. PF-06671008 elicits P-cadherin-dependent T cell cytotoxicity across multiple indications. PF-06671008 causes increased tumor-infiltrating T cells in mice, achieves higher tumor exposure in PBMC-engrafted versus non-PBMC-engrafted mice by reducing internalization of P-cadherin-bound drug, and induces T cell-mediated tumor killing, elevated serum cytokines, tumor regression, as well as prolonged half-life and maintained exposure in tumor-bearing mice. PF-06671008 can be used in the research of solid tumors .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
