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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1 Result for "
PF3166
" in MedChemExpress (MCE) Product Catalog:
Products (1)
1 Results for "PF3166" in MCE Product Catalog:
Cat. No.: HY-169206
CAS No.: 3126204-69-8
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PF-3166 is a non-covalent allosteric PAD2 inhibitor (human PAD2 IC50 = 150-610 nM and 5.47 μM; Kd = 221 nM). PF-3166 induces a conformational change by binding to the PAD2 dimer interface, causing calcium release from the high-affinity site and masking the other calcium-binding site, thereby preventing catalytic activation. PF-3166 exhibits selectivity for PAD2 over PAD3 and PAD4, and inhibits total cellular citrullination and reduces non-histone H3 citrullination. PF-3166 can be used for research on PAD2-related citrullination .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
