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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
PG-490
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "PG-490" in MCE Product Catalog:
78
Category:
Anti-aging Celastraceae Extract Tripterygium wilfordii Hook. f. Extract Biological Pesticide Research Agricultural Research Plant Terpenoids Diterpenoids Disease Research Fields Cancer
Target:
Cat. No.: HY-16363
CAS No.: 195883-06-8
Synonyms: PG 490-88
Research Areas:
Omtriptolide (PG490-88) is a derivative proagent of triptolide purified from the Chinese herb.
Cat. No.: HY-32735S
Synonyms: PG490-d3
Cat. No.: HY-32735R
CAS No.: 38748-32-2
Synonyms: PG490 (Standard)
Category:
Plant Celastraceae Extract Terpenoids Diterpenoids Tripterygium wilfordii Hook. f. Extract
Target:
Cat. No.: HY-32735C
CAS No.: 144539-79-7
Synonyms: (14R)-PG490
Target:
Research Areas:
(14R)-Triptolide ((14R)-PG490) (Compound T59) is a Triptolide (HY-32735) derivative. (14R)-Triptolide shows anti-cancer activity against multiple cancer cells with IC50 of 0.477-2.53 μM. (14R)-Triptolide can be used for the research of cancer, such as ovarian cancer and colon cancer .
Cat. No.: HY-16362
CAS No.: 195883-09-1
Synonyms: PG 490-88Na
Research Areas:
Omtriptolide sodium (PG490-88Na) is a derivative of Triptolide (HY-32735). Omtriptolide sodium exhibits significant immunosuppressive, anti-fibrotic and anti-inflammatory properties. The mechanism of action of Omtriptolide sodium is diverse, including inhibiting T cell activation and proliferation, inducing T cell apoptosis (apoptosis), blocking fibroblast maturation/proliferation, inhibiting TGF-β mRNA expression, and suppressing pro-inflammatory cytokines (such as IL-2, IFN-γ, TNF-α) by blocking transcription factors such as NF-κB. Omtriptolide sodium can be used for research on obstructive airway diseases, pulmonary fibrosis and graft-versus-host disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
