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8 Results for "

PHD-IN-2

" in MedChemExpress (MCE) Product Catalog:

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PHD-IN-2

Cat. No.: HY-156527

CAS No.: 2924182-42-1

Target:

HIF/HIF Prolyl-Hydroxylase

Research Areas:

Cancer

PHD-IN-2 (Compound 91) is a PHD antagonist (IC₅₀: < 5 nM). PHD-IN-2 induces erythropoietin synthesis in HEP3B cells (EC₅₀: <2.5 μM). PHD-IN-2 can be used for research of cardiovascular disorders, metabolic disorders, hematological disorders, pulmonary disorders, kidney disorders, liver disorders, wound healing disorders, and cancer .

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TP0463518

1 Cited Publications

Cat. No.: HY-112144

CAS No.: 1558021-37-6

Purity: 99.25%

Target:

HIF/HIF Prolyl-Hydroxylase

Research Areas:

Metabolic Disease Inflammation/Immunology

TP0463518 is an orally active, competitive pan-inhibitor of hypoxia-inducible factor prolyl hydroxylases PHD1/2/3. TP0463518 competitively inhibits human PHD1 (IC₅₀=18 nM), PHD2 (K_i=5.3 nM), and PHD3 (IC₅₀=63 nM), and targets monkey PHD2 with an IC₅₀ of 22 nM. TP0463518 inhibits PHD-catalyzed hydroxylation to stabilize HIFα, thereby upregulating erythropoietin (EPO) expression and enhancing intestinal iron absorption (such as increased DMT-1 and dCYTb expression), improving anemia. TP0463518 is mainly used for the research of renal anemia and inflammatory anemia ^[2].

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N-Oxalylglycine

1 Cited Publications

Cat. No.: HY-12315

CAS No.: 5262-39-5

Purity: 99.28%

Synonyms: N-OxaloglycINe

Target:

Histone Demethylase HIF/HIF Prolyl-Hydroxylase

Research Areas:

Cancer

N-Oxalylglycine (N-Oxaloglycine) is a Jumonji C-domain-containing histone lysine demethylase inhibitor. N-Oxalylglycine inhibits JMJD2A, JMJD2C and JMJD2D. N-Oxalylglycine also inhibits HIF prolylhydroxylase domain-1 (PHD-1) and PHD-2, with an IC₅₀ of 2.1 μM and 5.6 μM, respectively ^[2].

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