Target:

Research Areas:

PhD2 is an antimicrobial peptide derived from monkey white blood cells. PhD2 has activity against bacteria and fungus Candida albicans .

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22

IOX2

22 Publications Verification

Cat. No.: HY-15468

CAS No.: 931398-72-0

Purity: 98.02%

Target:

HIF/HIF Prolyl-Hydroxylase

Research Areas:

Cancer

IOX2, a chemical probe, is a specific prolyl hydroxylase-2 (PHD2) inhibitor with IC₅₀ of 22 nM. IOX2 regulates platelet function and arterial thrombosis by upregulating HIF-1α expression and inhibiting ROS production. IOX2 can be used in the study of thrombotic diseases ^[2].

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8

Molidustat

8 Cited Publications

Cat. No.: HY-12654

CAS No.: 1154028-82-6

Purity: 98.58%

Synonyms: BAY 85-3934

Target:

HIF/HIF Prolyl-Hydroxylase

Research Areas:

Cardiovascular Disease

Molidustat (BAY 85-3934) is an orally active inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with IC₅₀ values of 480 nM, 280 nM, and 450 nM for PHD1, PHD2, and PHD3, respectively. Molidustat can elevate the levels of circulating erythropoietin (EPO) to near-normal physiological ranges. Molidustat can be utilized in the research of renal anemia ^[2].

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8

IOX4

8 Cited Publications

Cat. No.: HY-120110

CAS No.: 1154097-71-8

Purity: 99.83%

Target:

HIF/HIF Prolyl-Hydroxylase

Research Areas:

Neurological Disease Inflammation/Immunology

IOX4 is a selective HIF prolyl-hydroxylase 2 (PHD2) inhibitor with an IC₅₀ value of 1.6 nM, induces HIFα in cells and in wildtype mice with marked induction in the brain tissue. IOX4 competes with and displaces 2-oxoglutarate (2OG) at the active site of PHD2 .

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6

FG-2216

6 Cited Publications

Cat. No.: HY-15641

CAS No.: 223387-75-5

Purity: 99.46%

Synonyms: IOX3; YM311

Target:

HIF/HIF Prolyl-Hydroxylase

Research Areas:

Metabolic Disease

FG-2216 (IOX3) is a potent and orally active inhibitor of HIF prolyl hydroxylase-2 (PHD2), with an IC₅₀ of 3.9 μM. FG-2216 induces robust erythropoietin and modest fetal hemoglobin in vivo ^[2] .

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4

MK-8617

4 Cited Publications

Cat. No.: HY-101023

CAS No.: 1187990-87-9

Purity: 99.92%

Target:

HIF/HIF Prolyl-Hydroxylase

Research Areas:

Inflammation/Immunology

MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC₅₀ of 1 nM for PHD2.

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1

TP0463518

1 Cited Publications

Cat. No.: HY-112144

CAS No.: 1558021-37-6

Purity: 99.25%

Target:

HIF/HIF Prolyl-Hydroxylase

Research Areas:

Metabolic Disease Inflammation/Immunology

TP0463518 is an orally active, competitive pan-inhibitor of hypoxia-inducible factor prolyl hydroxylases PHD1/2/3. TP0463518 competitively inhibits human PHD1 (IC₅₀=18 nM), PHD2 (K_i=5.3 nM), and PHD3 (IC₅₀=63 nM), and targets monkey PHD2 with an IC₅₀ of 22 nM. TP0463518 inhibits PHD-catalyzed hydroxylation to stabilize HIFα, thereby upregulating erythropoietin (EPO) expression and enhancing intestinal iron absorption (such as increased DMT-1 and dCYTb expression), improving anemia. TP0463518 is mainly used for the research of renal anemia and inflammatory anemia ^[2].

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1

N-Oxalylglycine

1 Cited Publications

Cat. No.: HY-12315

CAS No.: 5262-39-5

Purity: 99.28%

Synonyms: N-Oxaloglycine

Target:

Histone Demethylase HIF/HIF Prolyl-Hydroxylase

Research Areas:

Cancer

N-Oxalylglycine (N-Oxaloglycine) is a Jumonji C-domain-containing histone lysine demethylase inhibitor. N-Oxalylglycine inhibits JMJD2A, JMJD2C and JMJD2D. N-Oxalylglycine also inhibits HIF prolylhydroxylase domain-1 (PHD-1) and PHD-2, with an IC₅₀ of 2.1 μM and 5.6 μM, respectively ^[2].

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