39 Results for "

PI3K isoform

" in MedChemExpress (MCE) Product Catalog:
Products (39)

39 Results for "PI3K isoform" in MCE Product Catalog:

42
SAR405
SAR405
0 Images
42 Publications Verification
Cat. No.: HY-12481
CAS No.: 1523406-39-4
Purity:  99.74%
Target:  

PI3K Autophagy

Research Areas:  

Cancer

SAR405 is a first-in-class, selective, and ATP-competitive PI3K class III (PIK3C3) isoform Vps34 inhibitor (IC50=1.2 nM; Kd=1.5 nM). SAR405 inhibits autophagy induced either by starvation or by mTOR inhibition. Anticancer activity .
loading...
    loading...
View All Sizes
12
GSK2636771
GSK2636771
0 Images
12 Cited Publications
Cat. No.: HY-15245
CAS No.: 1372540-25-4
Purity:  99.59%
Target:  

PI3K

Research Areas:  

Cancer

GSK2636771 is a potent, selective and orally bioavailable inhibitor of PI3Kβ with a Ki of 0.89 nM and an IC50 of 5.2 nM, showing 900-fold selectivity over p110α and p110γ, and 10-fold selectivity over p110δ isoforms.
loading...
    loading...
View All Sizes
8
Samotolisib
Samotolisib
0 Images
8 Cited Publications
Cat. No.: HY-12513
CAS No.: 1386874-06-1
Purity:  99.27%
Synonyms: LY3023414
Target:  

PI3K DNA-PK mTOR Autophagy

Research Areas:  

Cancer

Samotolisib (LY3023414) potently and selectively inhibits class I PI3K isoforms, DNA-PK, and mTORC1/2 with IC50s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, DNA-PK and mTOR, respectively. Samotolisib potently inhibits mTORC1/2 at low nanomolar concentrations .
loading...
    loading...
View All Sizes
7
phospho-PI3 Kinase p110 beta (Ser1070) Antibody
phospho-PI3 Kinase p110 beta (Ser1070) Antibody
0 Images
7 Cited Publications
Cat. No.: HY-P81211
Synonyms: PI3-kinase p110 subunit beta; p-PI3Kβ(Ser1070); PI 3-kinase C2β; p110 BETA; p110Beta; Phosphatidylinositol 3 kinase catalytic beta polypeptide; Phosphatidylinositol 4 5 bisphosphate 3 kinase 110 kDa catalytic subunit beta; Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit beta isoform; Phosphatidylinositol-4; Phosphoinositide 3 kinase catalytic beta polypeptide; PI3 kinase p110 subunit beta; PI3-kinase subunit beta; PI3K; PI3K beta; PI3K-beta; PI3Kbeta; PI3KCB; PIK3C1; PIk3cb; PK3CB_HUMAN; PtdIns 3 kinase p110; PtdIns-3-kinase subunit beta; PtdIns-3-kinase subunit p110-beta; 5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; 5-bisphosphate 3-kinase catalytic subunit beta isoform.

Host:  

Rabbit

Application:  

WB, IHC-P, IHC-F, ICC/IF

Reactivity:  

Human, Mouse, Rat

loading...
    loading...
View All Sizes
3
Parsaclisib
Parsaclisib
0 Images
3 Cited Publications
Cat. No.: HY-109068
CAS No.: 1426698-88-5
Purity:  99.20%
Synonyms: INCB050465; IBI-376
Target:  

PI3K

Research Areas:  

Cancer

Parsaclisib (INCB050465) is a potent, selective and orally active inhibitor of PI3Kδ, with an IC50 of 1 nM at 1 mM ATP. Parsaclisib shows approximately 20000-fold selectivity over other PI3K class I isoforms. Parsaclisib can be used for the research of relapsed or refractory B-cell malignancies .
loading...
    loading...
View All Sizes
3
Parsaclisib hydrochloride
Parsaclisib hydrochloride
0 Images
3 Cited Publications
Cat. No.: HY-109068A
CAS No.: 1995889-48-9
Synonyms: INCB050465 hydrochloride; IBI-376 hydrochloride
Target:  

PI3K

Research Areas:  

Cancer

Parsaclisib hydrochloride (INCB050465 hydrochloride) is a potent, selective and orally active inhibitor of PI3Kδ, with an IC50 of 1 nM at 1 mM ATP. Parsaclisib hydrochloride shows approximately 20000-fold selectivity over other PI3K class I isoforms. Parsaclisib hydrochloride can be used for the research of relapsed or refractory B-cell malignancies .
loading...
    loading...
View All Sizes
2
TG 100713
TG 100713
0 Images
2 Cited Publications
Cat. No.: HY-13514
CAS No.: 925705-73-3
Purity:  99.49%
Target:  

PI3K

Research Areas:  

Cancer

TG 100713 is an inhibitor of PI3K, with IC50s of 24, 50, 165, and 215 nM for PI3Kδ, γ, α and β isoforms respectively .
loading...
    loading...
View All Sizes
1
Sonolisib
Sonolisib
0 Images
1 Cited Publications
Cat. No.: HY-N6775
CAS No.: 502632-66-8
Synonyms: PX-866
Target:  

PI3K

Research Areas:  

Cancer

Sonolisib (PX-866), an improved Wortmannin analogue, is an oral, irreversible, and pan-isoform inhibitor of PI3K (IC50=0.1 nM (p110α), 1.0 nM (p120γ), 2.9 nM (p110δ)). Antitumor activity .
loading...
    loading...
View All Sizes
1
AS-604850
AS-604850
0 Images
1 Cited Publications
Cat. No.: HY-13531
CAS No.: 648449-76-7
Purity:  99.95%
Target:  

PI3K

Research Areas:  

Cancer

AS-604850 is a potent, selective and ATP-competitive PI3Kγ inhibitor with an IC50 value of 0.25 μM and a Ki value of 0.18 μM. AS-604850 shows isoform selective inhibitor of PI3Kγ with over 30-fold selectivity for PI3Kδ and β, and 18-fold selectivity over PI3Kα, respectively .
loading...
    loading...
View All Sizes
1
Orobol
Orobol
0 Images
1 Cited Publications
Cat. No.: HY-N3127
CAS No.: 480-23-9
Category:  

Flavonoids 500 - Internal Server Error | MedChemExpress

Oops!

Sorry, Something went wrong on our server.
Our team has been notified and is working to fix the issue.