94

Go 6983

94 Publications Verification

Cat. No.: HY-13689

CAS No.: 133053-19-7

Purity: 99.32%

Synonyms: Gö 6983; Goe 6983

Target:

PKC

Research Areas:

Cancer

Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ, PKCδ and PKCζ with IC₅₀ of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively.

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46

Bisindolylmaleimide I

46 Cited Publications

Cat. No.: HY-13867

CAS No.: 133052-90-1

Purity: 98.15%

Synonyms: GF109203X; Go 6850

Target:

PKC GSK-3

Research Areas:

Metabolic Disease Cancer

Bisindolylmaleimide I (GF109203X) is a cell-permeable and reversible PKC inhibitor (IC₅₀ of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ. Bisindolylmaleimide I is also a GSK-3 inhibitor .

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46

Bisindolylmaleimide I hydrochloride

46 Cited Publications

Cat. No.: HY-13867A

CAS No.: 176504-36-2

Purity: 99.18%

Synonyms: GF109203X hydrochloride; Go 6850 hydrochloride

Target:

PKC GSK-3

Research Areas:

Metabolic Disease Cancer

Bisindolylmaleimide I (GF109203X) hydrochloride is a cell-permeable and reversible PKC inhibitor (IC₅₀ of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ. Bisindolylmaleimide I hydrochloride is also a GSK-3 inhibitor .

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14

Ro 31-8220 mesylate

14 Cited Publications

Cat. No.: HY-13866

CAS No.: 138489-18-6

Purity: 99.57%

Synonyms: Ro 31-8220 methanesulfonate; Bisindolylmaleimide IX mesylate

Target:

PKC JNK

Research Areas:

Cardiovascular Disease Neurological Disease Cancer

Ro 31-8220 mesylate is a potent PKC inhibitor, with IC₅₀s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC₅₀s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7. Ro 31-8220 mesylate can also inhibit the expression of MKP-1, induce the expression of c-Jun, and activate JNK, and these effects possess pharmacological properties independent of PKC .

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14

Ro 31-8220 formic

14 Cited Publications

Cat. No.: HY-13866B

Synonyms: Bisindolylmaleimide IX formic

Target:

PKC JNK

Research Areas:

Cancer

Ro 31-8220 formic is a potent PKC inhibitor, with IC₅₀s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 formic also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC₅₀s, 3, 8, 15, and 38 nM, respectively). Ro 31-8220 formic can also inhibit the expression of MKP-1, induce the expression of c-Jun, and activate JNK, and these effects possess pharmacological properties independent of PKC .

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12

Enzastaurin

12 Cited Publications

Cat. No.: HY-10342

CAS No.: 170364-57-5

Purity: 99.92%

Synonyms: LY317615

Target:

PKC Autophagy Apoptosis

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

Enzastaurin (LY317615) is a potent, selective, and CNS-penetrant PKCβ inhibitor with an IC₅₀ of 6 nM, showing 6- to 20-fold selectivity over PKCα, PKCγ and PKCε .

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